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Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer

Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong and Ryan B. Corcoran
Eunice L. Kwak
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: rbcorcoran@partners.org ekwak@partners.org
Leanne G. Ahronian
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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Giulia Siravegna
Department of Oncology, University of Torino, Torino, Italy.Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.
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Benedetta Mussolin
Department of Oncology, University of Torino, Torino, Italy.Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.
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Darrell R. Borger
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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Jason T. Godfrey
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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Nicholas A. Jessop
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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Jeffrey W. Clark
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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Lawrence S. Blaszkowsky
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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David P. Ryan
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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Jochen K. Lennerz
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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A. John Iafrate
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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Alberto Bardelli
Department of Oncology, University of Torino, Torino, Italy.Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.
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Theodore S. Hong
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
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Ryan B. Corcoran
Massachusetts General Hospital Cancer Center, Boston, Massachusetts.Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: rbcorcoran@partners.org ekwak@partners.org
DOI: 10.1158/2159-8290.CD-15-0748 Published December 2015
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Article Information

Volume 5, Issue 12, pp. 1271-1281

DOI 
https://doi.org/10.1158/2159-8290.CD-15-0748
PubMed 
26432108

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received June 19, 2015
  • Revision received September 24, 2015
  • Accepted September 29, 2015
  • Published first October 2, 2015.

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  • Previous version (October 2, 2015 - 06:07).
  • Previous version (November 13, 2015 - 06:53).
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©2015 American Association for Cancer Research.

Author Information

  1. Eunice L. Kwak1,2,*,
  2. Leanne G. Ahronian1,2,
  3. Giulia Siravegna3,4,
  4. Benedetta Mussolin3,4,
  5. Darrell R. Borger5,
  6. Jason T. Godfrey1,2,
  7. Nicholas A. Jessop5,
  8. Jeffrey W. Clark1,2,
  9. Lawrence S. Blaszkowsky1,2,
  10. David P. Ryan1,2,
  11. Jochen K. Lennerz5,
  12. A. John Iafrate5,
  13. Alberto Bardelli3,4,
  14. Theodore S. Hong1,6 and
  15. Ryan B. Corcoran1,2,*
  1. 1Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  2. 2Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  3. 3Department of Oncology, University of Torino, Torino, Italy.
  4. 4Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.
  5. 5Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  6. 6Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Ryan B. Corcoran, Massachusetts General Hospital Cancer Center, 149 13th Street, Boston, MA 02129. Phone: 617-726-8599; Fax: 617-643-0798; E-mail: rbcorcoran{at}partners.org; and Eunice L. Kwak, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114. Phone: 617-726-3252; Fax: 617-726-0452; E-mail: ekwak{at}partners.org
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Cancer Discovery: 5 (12)
December 2015
Volume 5, Issue 12
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Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer
Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong and Ryan B. Corcoran
Cancer Discov December 1 2015 (5) (12) 1271-1281; DOI: 10.1158/2159-8290.CD-15-0748

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Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer
Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong and Ryan B. Corcoran
Cancer Discov December 1 2015 (5) (12) 1271-1281; DOI: 10.1158/2159-8290.CD-15-0748
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