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Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas

Peter S. Hammerman, D. Neil Hayes and Jennifer R. Grandis
Peter S. Hammerman
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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D. Neil Hayes
3Department of Hematology/Oncology, University of North Carolina Lineberger Cancer Center, Chapel Hill, North Carolina.
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Jennifer R. Grandis
4Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
5Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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  • For correspondence: grandisjr@upmc.edu
DOI: 10.1158/2159-8290.CD-14-1205 Published March 2015
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Abstract

Summary: Large and comprehensive genomic surveys of head and neck squamous cell carcinomas (HNSCC) are now greatly increasing our understanding of the diversity of this disease and the key genomic changes that drive these tumors. The results from these studies are beginning to inform the introduction of novel therapies for patients with HNSCCs. Here, we review some of the key findings from recent genomic studies of head and neck cancers, including the most comprehensive study to date from The Cancer Genome Atlas Network. Cancer Discov; 5(3); 239–44. ©2015 AACR.

  • ©2015 American Association for Cancer Research.
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Cancer Discovery: 5 (3)
March 2015
Volume 5, Issue 3
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Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas
Peter S. Hammerman, D. Neil Hayes and Jennifer R. Grandis
Cancer Discov March 1 2015 (5) (3) 239-244; DOI: 10.1158/2159-8290.CD-14-1205

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Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas
Peter S. Hammerman, D. Neil Hayes and Jennifer R. Grandis
Cancer Discov March 1 2015 (5) (3) 239-244; DOI: 10.1158/2159-8290.CD-14-1205
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    • Abstract
    • Introduction
    • The Genomic Landscape of Non–HPV-Driven HNSCCs
    • HPV-Positive HNSCC
    • Genomics to Targeted Therapeutics
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eISSN: 2159-8290
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