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Cancer Discovery

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Research Articles

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti and Pier Paolo Pandolfi
Andrea Lunardi
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Shohreh Varmeh
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Ming Chen
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Riccardo Taulli
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Jlenia Guarnerio
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Ugo Ala
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Nina Seitzer
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Tomoki Ishikawa
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Brett S. Carver
Cancer Biology and Genetics Program, Sloan Kettering Institute, Division of Urology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
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Robin M. Hobbs
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Valentina Quarantotti
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Christopher Ng
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Alice H. Berger
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Caterina Nardella
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Laura Poliseno
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Rodolfo Montironi
Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy.
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Mireia Castillo-Martin
Department of Pathology, Mount Sinai School of Medicine, New York, New York.
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Carlos Cordon-Cardo
Department of Pathology, Mount Sinai School of Medicine, New York, New York.
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Sabina Signoretti
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
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Pier Paolo Pandolfi
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: ppandolf@bidmc.harvard.edu
DOI: 10.1158/2159-8290.CD-13-1050 Published May 2015
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Article Information

Volume 5, Issue 5, pp. 550-563

DOI 
https://doi.org/10.1158/2159-8290.CD-13-1050
PubMed 
25653093

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received December 30, 2013
  • Revision received January 27, 2015
  • Accepted January 27, 2015
  • Published first February 4, 2015.

Article Versions

  • Previous version (February 4, 2015 - 07:06).
  • Previous version (April 20, 2015 - 07:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Andrea Lunardi1,
  2. Shohreh Varmeh1,
  3. Ming Chen1,
  4. Riccardo Taulli1,
  5. Jlenia Guarnerio1,
  6. Ugo Ala1,
  7. Nina Seitzer1,
  8. Tomoki Ishikawa1,
  9. Brett S. Carver2,
  10. Robin M. Hobbs1,
  11. Valentina Quarantotti1,
  12. Christopher Ng1,
  13. Alice H. Berger1,
  14. Caterina Nardella1,
  15. Laura Poliseno1,
  16. Rodolfo Montironi3,
  17. Mireia Castillo-Martin4,
  18. Carlos Cordon-Cardo4,
  19. Sabina Signoretti5,6 and
  20. Pier Paolo Pandolfi1,*
  1. 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  2. 2Cancer Biology and Genetics Program, Sloan Kettering Institute, Division of Urology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  3. 3Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy.
  4. 4Department of Pathology, Mount Sinai School of Medicine, New York, New York.
  5. 5Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  6. 6Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Pier Paolo Pandolfi, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215. Phone: 617-735-2121; Fax: 617-735-2120; E-mail: ppandolf{at}bidmc.harvard.edu
  1. A. Lunardi and S. Varmeh contributed equally to this article.

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Cancer Discovery: 5 (5)
May 2015
Volume 5, Issue 5
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Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis
Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti and Pier Paolo Pandolfi
Cancer Discov May 1 2015 (5) (5) 550-563; DOI: 10.1158/2159-8290.CD-13-1050

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Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis
Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti and Pier Paolo Pandolfi
Cancer Discov May 1 2015 (5) (5) 550-563; DOI: 10.1158/2159-8290.CD-13-1050
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