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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov September 1 2015 5 (9) 893-895; DOI:10.1158/2159-8290.CD-ITI5-9

In the Spotlight

  • In the Spotlight
    Cancer Metastasis: Perivascular Macrophages Under Watch
    Ece Kadioglu and Michele De Palma
    Cancer Discov September 1 2015 5 (9) 906-908; DOI:10.1158/2159-8290.CD-15-0819

  • In the Spotlight
    Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer
    Marinus R. Heideman, Anna Frei and Nancy E. Hynes
    Cancer Discov September 1 2015 5 (9) 909-911; DOI:10.1158/2159-8290.CD-15-0871

  • In the Spotlight
    Mass Cytometry: A High-Throughput Platform to Visualize the Heterogeneity of Acute Myeloid Leukemia
    Priscilla Do and John C. Byrd
    Cancer Discov September 1 2015 5 (9) 912-914; DOI:10.1158/2159-8290.CD-15-0905

Mini Review

  • Mini Review
    Adaptive Immune Resistance: How Cancer Protects from Immune Attack
    Antoni Ribas
    Cancer Discov September 1 2015 5 (9) 915-919; DOI:10.1158/2159-8290.CD-15-0563

Research Articles

  • Research Articles
    A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma
    Lisa Mirabello, Roelof Koster, Branden S. Moriarity, Logan G. Spector, Paul S. Meltzer, Joy Gary, Mitchell J. Machiela, Nathan Pankratz, Orestis A. Panagiotou, David Largaespada, Zhaoming Wang, Julie M. Gastier-Foster, Richard Gorlick, Chand Khanna, Silvia Regina Caminada de Toledo, Antonio S. Petrilli, Ana Patiño-Garcia, Luis Sierrasesúmaga, Fernando Lecanda, Irene L. Andrulis, Jay S. Wunder, Nalan Gokgoz, Massimo Serra, Claudia Hattinger, Piero Picci, Katia Scotlandi, Adrienne M. Flanagan, Roberto Tirabosco, Maria Fernanda Amary, Dina Halai, Mandy L. Ballinger, David M. Thomas, Sean Davis, Donald A. Barkauskas, Neyssa Marina, Lee Helman, George M. Otto, Kelsie L. Becklin, Natalie K. Wolf, Madison T. Weg, Margaret Tucker, Sholom Wacholder, Joseph F. Fraumeni Jr, Neil E. Caporaso, Joseph F. Boland, Belynda D. Hicks, Aurelie Vogt, Laurie Burdett, Meredith Yeager, Robert N. Hoover, Stephen J. Chanock and Sharon A. Savage
    Cancer Discov September 1 2015 5 (9) 920-931; DOI:10.1158/2159-8290.CD-15-0125

    The risk variant rs7034162 in NFIB contributes to osteosarcoma metastasis susceptibility.

  • Research Articles
    Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage–Derived VEGFA
    Allison S. Harney, Esther N. Arwert, David Entenberg, Yarong Wang, Peng Guo, Bin-Zhi Qian, Maja H. Oktay, Jeffrey W. Pollard, Joan G. Jones and John S. Condeelis
    Cancer Discov September 1 2015 5 (9) 932-943; DOI:10.1158/2159-8290.CD-15-0012

    Hyperpermeability of tumor vasculature is dynamic and restricted to the Tumor MicroEnvironment of Metastasis (TMEM).

  • Research Articles
    HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance
    Kideok Jin, Sunju Park, Wei Wen Teo, Preethi Korangath, Sean Soonweng Cho, Takahiro Yoshida, Balázs Győrffy, Chirayu Pankaj Goswami, Harikrishna Nakshatri, Leigh-Ann Cruz, Weiqiang Zhou, Hongkai Ji, Ying Su, Muhammad Ekram, Zhengsheng Wu, Tao Zhu, Kornelia Polyak and Saraswati Sukumar
    Cancer Discov September 1 2015 5 (9) 944-959; DOI:10.1158/2159-8290.CD-15-0090

    HOXB7 is upregulated by MYC-mediated suppression of miR-196a and enhances expression of ER target genes in tamoxifen-resistant breast cancer cells.

  • Research Articles
    Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer
    Erin M. Tricker, Chunxiao Xu, Sharmeen Uddin, Marzia Capelletti, Dalia Ercan, Atsuko Ogino, Christine A. Pratilas, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong and Pasi A. Jänne
    Cancer Discov September 1 2015 5 (9) 960-971; DOI:10.1158/2159-8290.CD-15-0063

    Acquired resistance to EGFR inhibitors can be prevented with dual EGFR and MEK inhibition, which results in prolonged ERK1/2 inhibition and increased apoptosis in EGFR-mutant NSCLC.

  • Research Articles
    Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma
    Francesca Cottini, Teru Hideshima, Rikio Suzuki, Yu-Tzu Tai, Giampaolo Bianchini, Paul G. Richardson, Kenneth C. Anderson and Giovanni Tonon
    Cancer Discov September 1 2015 5 (9) 972-987; DOI:10.1158/2159-8290.CD-14-0943

    Upregulation of MYC in multiple myeloma cells drives DNA damage via replicative stress and ROS induction, and confers sensitivity to ATR inhibitors and small-molecule inducers of ROS.

  • Research Articles
    Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy
    Gregory K. Behbehani, Nikolay Samusik, Zach B. Bjornson, Wendy J. Fantl, Bruno C. Medeiros and Garry P. Nolan
    Cancer Discov September 1 2015 5 (9) 988-1003; DOI:10.1158/2159-8290.CD-15-0298

    High-dimensional analysis of patient-derived AML cells using mass cytometry identifies changes in immunophenotypic patterns and cell-cycle kinetics that are predictive of AML subtype and chemotherapeutic response.

News in Brief

  • News in Brief
    People
    Cancer Discov September 1 2015 5 (9) 896-896; DOI:10.1158/2159-8290.CD-NB2015-103

  • News in Brief
    Gefitinib Approved for EGFR-Mutated NSCLC
    Cancer Discov September 1 2015 5 (9) 896-896; DOI:10.1158/2159-8290.CD-NB2015-111

  • News in Brief
    Debate on Naming of Biosimilars Continues
    Cancer Discov September 1 2015 5 (9) 896-897; DOI:10.1158/2159-8290.CD-NB2015-107

  • News in Brief
    Light-Activated Therapy Kills Cancer Cells
    Cancer Discov September 1 2015 5 (9) 897-897; DOI:10.1158/2159-8290.CD-NB2015-110

  • News in Brief
    CRUK Invests £15 Million in Research Hubs
    Cancer Discov September 1 2015 5 (9) 897-898; DOI:10.1158/2159-8290.CD-NB2015-104

  • News in Brief
    New Compound Targets Warburg Effect
    Cancer Discov September 1 2015 5 (9) 898-898; DOI:10.1158/2159-8290.CD-NB2015-108

  • News in Brief
    Device Captures CTC Clusters in Blood
    Cancer Discov September 1 2015 5 (9) 898-899; DOI:10.1158/2159-8290.CD-NB2015-095

  • News in Brief
    AIM2 Blocks Colon Cancer in Three Ways
    Cancer Discov September 1 2015 5 (9) 899-900; DOI:10.1158/2159-8290.CD-NB2015-105

  • News in Brief
    New Insight into Mucinous Ovarian Cancer
    Cancer Discov September 1 2015 5 (9) 900-900; DOI:10.1158/2159-8290.CD-NB2015-098

  • News in Brief
    Noted
    Cancer Discov September 1 2015 5 (9) 900-900; DOI:10.1158/2159-8290.CD-NB2015-102

  • News in Brief
    DNA-PKcs Emerges as Master Driver of Metastasis
    Cancer Discov September 1 2015 5 (9) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2015-106

  • News in Brief
    Tool Shows Relative Value of Cancer Drugs
    Cancer Discov September 1 2015 5 (9) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2015-100

  • News in Brief
    Epigenetic Drugs Reverse Leukemia Resistance
    Cancer Discov September 1 2015 5 (9) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2015-101

  • News in Brief
    Genomic Study Divides Up Cutaneous Melanomas
    Cancer Discov September 1 2015 5 (9) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2015-097

Research Watch

Autophagy

  • Research Watch
    Dual Inhibition of ULK1 and mTOR Enhances Tumor Cell Apoptosis
    Cancer Discov September 1 2015 5 (9) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2015-127

Breast Cancer

  • Research Watch
    Progesterone Receptor Determines ERα Function
    Cancer Discov September 1 2015 5 (9) 905-905; DOI:10.1158/2159-8290.CD-RW2015-135

Clinical Trials

  • Research Watch
    The ABC Subtype of Diffuse Large B-Cell Lymphoma Is Responsive to Ibrutinib
    Cancer Discov September 1 2015 5 (9) 904-904; DOI:10.1158/2159-8290.CD-RW2015-141

  • Research Watch
    Affinity-Enhanced TCR-Engineered T Cells Induce Antimyeloma Responses
    Cancer Discov September 1 2015 5 (9) 901-901; DOI:10.1158/2159-8290.CD-RW2015-145

DNA Damage

  • Research Watch
    Spliceosome–ATM Reciprocal Regulation Modulates Alternative Splicing
    Cancer Discov September 1 2015 5 (9) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2015-128

Epigenetics

  • Research Watch
    The Global H3K4 Methylation State Controls Leukemia Stem Cell Fate
    Cancer Discov September 1 2015 5 (9) 902-902; DOI:10.1158/2159-8290.CD-RW2015-140

Esophageal Cancer

  • Research Watch
    Sequencing Highlights the Genetic Progression of Barrett Esophagus to EAC
    Cancer Discov September 1 2015 5 (9) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2015-143

Liposarcoma

  • Research Watch
    KLF6 Silencing via Increased H3K9me3 Drives Liposarcoma Dedifferentiation
    Cancer Discov September 1 2015 5 (9) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2015-142

Lung Cancer

  • Research Watch
    Genomic Profiling Identifies Recurrent Genetic Alterations in SCLC
    Cancer Discov September 1 2015 5 (9) 903-903; DOI:10.1158/2159-8290.CD-RW2015-139

Lymphoma

  • Research Watch
    DDX3X Is the Most Frequently Mutated Gene in Natural Killer/T-cell Lymphoma
    Cancer Discov September 1 2015 5 (9) 901-901; DOI:10.1158/2159-8290.CD-RW2015-144

Metabolism

  • Research Watch
    Ketogenesis Drives BRAF–MEK1 Signaling in BRAFV600E-Positive Cancers
    Cancer Discov September 1 2015 5 (9) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2015-131

  • Research Watch
    mTORC1 Suppresses Consumption of Extracellular Proteins as Nutrients
    Cancer Discov September 1 2015 5 (9) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2015-132

Mitosis

  • Research Watch
    MYC Sensitizes Cancer Cells to Antimitotic Therapies
    Cancer Discov September 1 2015 5 (9) 905-905; DOI:10.1158/2159-8290.CD-RW2015-137

Myelodysplastic Syndrome

  • Research Watch
    CK1α Degradation Underlies Lenalidomide Activity in del(5q) MDS
    Cancer Discov September 1 2015 5 (9) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2015-130

Neuroblastoma

  • Research Watch
    Genomic Analysis Identifies Mutation Dynamics in Relapsed Neuroblastoma
    Cancer Discov September 1 2015 5 (9) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2015-129

Pancreatic Cancer

  • Research Watch
    MiT/TFE Proteins Mediate Metabolic Reprogramming in Pancreatic Cancer
    Cancer Discov September 1 2015 5 (9) 904-904; DOI:10.1158/2159-8290.CD-RW2015-136

Targeted Therapy

  • Research Watch
    A Type II JAK2 Inhibitor Is Active in JAK2-Dependent Malignancies
    Cancer Discov September 1 2015 5 (9) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2015-138

  • Research Watch
    Dual Checkpoint Abrogation Is Synergistic in KRAS-Mutant Cancer
    Cancer Discov September 1 2015 5 (9) 903-903; DOI:10.1158/2159-8290.CD-RW2015-133

  • Research Watch
    The ALK/ROS1 Inhibitor PF-06463922 Has Potency across Resistant ALK Mutants
    Cancer Discov September 1 2015 5 (9) 902-902; DOI:10.1158/2159-8290.CD-RW2015-134

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Cancer Discovery: 5 (9)
September 2015
Volume 5, Issue 9
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  • In This Issue
  • In the Spotlight
  • Mini Review
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  • Research Watch
    • Autophagy
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    • DNA Damage
    • Epigenetics
    • Esophageal Cancer
    • Liposarcoma
    • Lung Cancer
    • Lymphoma
    • Metabolism
    • Mitosis
    • Myelodysplastic Syndrome
    • Neuroblastoma
    • Pancreatic Cancer
    • Targeted Therapy
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