In This Issue
Cancer Discov September 1 2015 5 (9) 893-895; DOI:10.1158/2159-8290.CD-ITI5-9
The risk variant rs7034162 in NFIB contributes to osteosarcoma metastasis susceptibility.
Hyperpermeability of tumor vasculature is dynamic and restricted to the Tumor MicroEnvironment of Metastasis (TMEM).
HOXB7 is upregulated by MYC-mediated suppression of miR-196a and enhances expression of ER target genes in tamoxifen-resistant breast cancer cells.
Acquired resistance to EGFR inhibitors can be prevented with dual EGFR and MEK inhibition, which results in prolonged ERK1/2 inhibition and increased apoptosis in EGFR-mutant NSCLC.
Upregulation of MYC in multiple myeloma cells drives DNA damage via replicative stress and ROS induction, and confers sensitivity to ATR inhibitors and small-molecule inducers of ROS.
High-dimensional analysis of patient-derived AML cells using mass cytometry identifies changes in immunophenotypic patterns and cell-cycle kinetics that are predictive of AML subtype and chemotherapeutic response.