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Cancer Discovery
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Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy

Klaus Okkenhaug, Mariona Graupera and Bart Vanhaesebroeck
Klaus Okkenhaug
1Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
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  • For correspondence: bart.vanh@ucl.ac.uk klaus.okkenhaug@babraham.ac.uk mgraupera@idibell.cat
Mariona Graupera
2Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
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  • For correspondence: bart.vanh@ucl.ac.uk klaus.okkenhaug@babraham.ac.uk mgraupera@idibell.cat
Bart Vanhaesebroeck
3UCL Cancer Institute, University College London, London, United Kingdom.
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  • For correspondence: bart.vanh@ucl.ac.uk klaus.okkenhaug@babraham.ac.uk mgraupera@idibell.cat
DOI: 10.1158/2159-8290.CD-16-0716 Published October 2016
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Article Information

Volume 6, Issue 10, pp. 1090-1105

DOI 
https://doi.org/10.1158/2159-8290.CD-16-0716
PubMed 
27655435

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received June 28, 2016
  • Revision received August 1, 2016
  • Accepted August 2, 2016
  • Published first September 21, 2016.

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  • Previous version (September 21, 2016 - 06:17).
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©2016 American Association for Cancer Research.

Author Information

  1. Klaus Okkenhaug1,*,
  2. Mariona Graupera2,* and
  3. Bart Vanhaesebroeck3,*
  1. 1Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  2. 2Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
  3. 3UCL Cancer Institute, University College London, London, United Kingdom.
  1. ↵*Corresponding Authors:
    Bart Vanhaesebroeck, University College London, 72 Huntley Street, London WC1E 6BT, UK. Phone: 44-20-7679-6520; Fax: 44-20-7679-6817; E-mail: bart.vanh{at}ucl.ac.uk; Klaus Okkenhaug, Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Building 540, Babraham Research Campus, Cambridge, CB22 3AT, UK. Phone: 44-1223-496573; E-mail: klaus.okkenhaug{at}babraham.ac.uk; and Mariona Graupera, Vascular Signalling Laboratory, Institut d'Investigació Biomédica de Bellvitge (IDIBELL), Hospital Duran i Reynals, 3a planta – Gran Via de l'Hospitalet, 199, 08908 Hospitalet de Llobregat, Barcelona, Spain. Phone: 34-932607404; E-mail: mgraupera{at}idibell.cat
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Cancer Discovery: 6 (10)
October 2016
Volume 6, Issue 10
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Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
Klaus Okkenhaug, Mariona Graupera and Bart Vanhaesebroeck
Cancer Discov October 1 2016 (6) (10) 1090-1105; DOI: 10.1158/2159-8290.CD-16-0716

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Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
Klaus Okkenhaug, Mariona Graupera and Bart Vanhaesebroeck
Cancer Discov October 1 2016 (6) (10) 1090-1105; DOI: 10.1158/2159-8290.CD-16-0716
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  • Article
    • Abstract
    • Introduction
    • PI3K Pathway Inhibition in Cancer: Lessons Learned to Date
    • Examples of Drug Combination Strategies Based on the Cancer Cell–Intrinsic Roles of PI3K
    • Indirect Effects of PI3K Pathway Inhibition in Cancer
    • Future Directions
    • Disclosure of Potential Conflicts of Interest
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