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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov March 1 2016 6 (3) 217-219; DOI:10.1158/2159-8290.CD-ITI6-3

In the Spotlight

  • In the Spotlight
    B Cells Promote Pancreatic Tumorigenesis
    Ali Roghanian, Christopher Fraser, Marianna Kleyman and Jianzhu Chen
    Cancer Discov March 1 2016 6 (3) 230-232; DOI:10.1158/2159-8290.CD-16-0100

  • In the Spotlight
    Progress on Covalent Inhibition of KRASG12C
    Kenneth D. Westover, Pasi A. Jänne and Nathanael S. Gray
    Cancer Discov March 1 2016 6 (3) 233-234; DOI:10.1158/2159-8290.CD-16-0092

Review

  • Reviews
    miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
    Rajesha Rupaimoole, George A. Calin, Gabriel Lopez-Berestein and Anil K. Sood
    Cancer Discov March 1 2016 6 (3) 235-246; DOI:10.1158/2159-8290.CD-15-0893

Research Brief

  • Research Briefs | Free Article
    IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia
    Yuliya Pylayeva-Gupta, Shipra Das, Jesse S. Handler, Cristina H. Hajdu, Maryaline Coffre, Sergei B. Koralov and Dafna Bar-Sagi
    Cancer Discov March 1 2016 6 (3) 247-255; DOI:10.1158/2159-8290.CD-15-0843

    B cells are recruited to the pancreas during PDAC initiation and support tumor growth through IL35-mediated signaling.

Research Articles

  • Research Articles
    Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia
    Kyoung Eun Lee, Michelle Spata, Lauren J. Bayne, Elizabeth L. Buza, Amy C. Durham, David Allman, Robert H. Vonderheide and M. Celeste Simon
    Cancer Discov March 1 2016 6 (3) 256-269; DOI:10.1158/2159-8290.CD-15-0822

    HIF1α prevents PDAC initiation by suppressing protumorigenic B cell recruitment to the pancreas, which is required for PDAC progression.

  • Research Articles | Free Article
    Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
    Andrew J. Gunderson, Megan M. Kaneda, Takahiro Tsujikawa, Abraham V. Nguyen, Nesrine I. Affara, Brian Ruffell, Sara Gorjestani, Shannon M. Liudahl, Morgan Truitt, Peter Olson, Grace Kim, Douglas Hanahan, Margaret A. Tempero, Brett Sheppard, Bryan Irving, Betty Y. Chang, Judith A. Varner and Lisa M. Coussens
    Cancer Discov March 1 2016 6 (3) 270-285; DOI:10.1158/2159-8290.CD-15-0827

    Inhibition of PI3Kγ/BTK signaling between B cells and FcRγ-positive macrophages reactivates T cell–dependent immune responses and suppresses PDAC tumor growth in mice.

  • Research Articles | AuthorChoice
    Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma
    Maria Romina Girotti, Gabriela Gremel, Rebecca Lee, Elena Galvani, Dominic Rothwell, Amaya Viros, Amit Kumar Mandal, Kok Haw Jonathan Lim, Grazia Saturno, Simon J. Furney, Franziska Baenke, Malin Pedersen, Jane Rogan, Jacqueline Swan, Matthew Smith, Alberto Fusi, Deemesh Oudit, Nathalie Dhomen, Ged Brady, Paul Lorigan, Caroline Dive and Richard Marais
    Cancer Discov March 1 2016 6 (3) 286-299; DOI:10.1158/2159-8290.CD-15-1336

    Next-generation sequencing of circulating tumor DNA can be used to monitor response to therapy and identify potential treatment strategies, which can be validated in patient-derived or circulating tumor cell–derived xenografts.

  • Research Articles
    Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120
    Shih-Hsun Chen, Youyan Zhang, Robert D. Van Horn, Tinggui Yin, Sean Buchanan, Vipin Yadav, Igor Mochalkin, Swee Seong Wong, Yong Gang Yue, Lysiane Huber, Ilaria Conti, James R. Henry, James J. Starling, Gregory D. Plowman and Sheng-Bin Peng
    Cancer Discov March 1 2016 6 (3) 300-315; DOI:10.1158/2159-8290.CD-15-0896

    Previously unidentified BRAF in-frame deletions promote the formation of homodimers, which activate MAPK signaling and are sensitive to LY3009120.

  • Research Articles
    Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State
    Matthew P. Patricelli, Matthew R. Janes, Lian-Sheng Li, Rasmus Hansen, Ulf Peters, Linda V. Kessler, Yuching Chen, Jeff M. Kucharski, Jun Feng, Tess Ely, Jeffrey H. Chen, Sarah J. Firdaus, Anjali Babbar, Pingda Ren and Yi Liu
    Cancer Discov March 1 2016 6 (3) 316-329; DOI:10.1158/2159-8290.CD-15-1105

    Mutant KRASG12C exhibits a dynamic nucleotide state that is responsive to upstream signaling, and its activation can be selectively and potently suppressed by small-molecule binding to the GDP-bound state.

News in Brief

  • News in Brief
    People
    Cancer Discov March 1 2016 6 (3) 220-220; DOI:10.1158/2159-8290.CD-NB2016-005

  • News in Brief
    Panel Recommends Mammograms Start at 50
    Cancer Discov March 1 2016 6 (3) 220-220; DOI:10.1158/2159-8290.CD-NB2016-006

  • News in Brief
    Resensitizing Refractory ALK+ NSCLC: A Case Study
    Cancer Discov March 1 2016 6 (3) 220-221; DOI:10.1158/2159-8290.CD-NB2016-009

  • News in Brief
    Expanding Therapy for Neuroendocrine Tumors
    Cancer Discov March 1 2016 6 (3) 221-222; DOI:10.1158/2159-8290.CD-NB2016-010

  • News in Brief
    Pathway to Chromosomal Instability Revealed
    Cancer Discov March 1 2016 6 (3) 222-222; DOI:10.1158/2159-8290.CD-NB2016-007

  • News in Brief
    Vaccinating against HPV: A Call to Action
    Cancer Discov March 1 2016 6 (3) 222-223; DOI:10.1158/2159-8290.CD-NB2016-012

  • News in Brief
    Pembrolizumab Outperforms Docetaxel for NSCLC
    Cancer Discov March 1 2016 6 (3) 223-223; DOI:10.1158/2159-8290.CD-NB2016-008

  • News in Brief
    Noted
    Cancer Discov March 1 2016 6 (3) 223-223; DOI:10.1158/2159-8290.CD-NB2016-004

  • News in Brief
    FDA Approves Eribulin for Advanced Liposarcoma
    Cancer Discov March 1 2016 6 (3) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2016-011

  • News in Brief
    Idelalisib Bolsters CLL Regimen
    Cancer Discov March 1 2016 6 (3) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2016-002

News in Depth

  • News in Depth
    Does R&D Favor Advanced Cancer?
    Cancer Discov March 1 2016 6 (3) 224-224; DOI:10.1158/2159-8290.CD-ND2016-001

Research Watch

  • DNA Repair

    • Research Watch
      XPG Promotes Homologous Recombination Repair and Genomic Stability
      Cancer Discov March 1 2016 6 (3) OF3-OF3; DOI:10.1158/2159-8290.CD-RW2016-022

    • Research Watch
      FBXW7 Promotes Nonhomologous End-Joining Repair and Radioresistance
      Cancer Discov March 1 2016 6 (3) 225-225; DOI:10.1158/2159-8290.CD-RW2016-009

  • Drug Resistance

    • Research Watch
      Tumors Resistant to EGFR Inhibitors Can Arise via Different Mechanisms
      Cancer Discov March 1 2016 6 (3) 228-228; DOI:10.1158/2159-8290.CD-RW2016-023

    • Research Watch
      Tumor Suppression by PARP Inhibitors Is Potentiated by c-MET Inhibition
      Cancer Discov March 1 2016 6 (3) 229-229; DOI:10.1158/2159-8290.CD-RW2016-017

  • Epigenetics

    • Research Watch
      AML Fusions Require Epigenetic Modifiers to Transform Cells
      Cancer Discov March 1 2016 6 (3) OF4-OF4; DOI:10.1158/2159-8290.CD-RW2016-011

  • Genomic Instability

    • Research Watch
      FAN1 Acts as a Tumor Suppressor Preventing Genomic Instability
      Cancer Discov March 1 2016 6 (3) 226-226; DOI:10.1158/2159-8290.CD-RW2016-019

  • Glioma

    • Research Watch
      MYB–QKI Fusions Drive Angiocentric Glioma through Multiple Mechanisms
      Cancer Discov March 1 2016 6 (3) 228-228; DOI:10.1158/2159-8290.CD-RW2016-025

  • Immunology

    • Research Watch
      Cell Transformation Triggers the Expansion of Cytotoxic Lymphocytes
      Cancer Discov March 1 2016 6 (3) 227-227; DOI:10.1158/2159-8290.CD-RW2016-018

    • Research Watch
      Constitutively Active FOXO1 in Treg Cells Inhibits Tumor Growth
      Cancer Discov March 1 2016 6 (3) 226-226; DOI:10.1158/2159-8290.CD-RW2016-016

  • Immunotherapy

    • Research Watch
      Dual Activation of Engineered T Cells Allows for Precise Tumor Killing
      Cancer Discov March 1 2016 6 (3) 227-227; DOI:10.1158/2159-8290.CD-RW2016-021

    • Research Watch
      Atezolizumab Shows Antitumor Activity in Renal Cell Carcinoma
      Cancer Discov March 1 2016 6 (3) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2016-013

  • Leukemia

    • Research Watch
      Epigenetic Changes in B-Cell Maturation Underlie Diverse CLL Phenotypes
      Cancer Discov March 1 2016 6 (3) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2016-015

  • Medulloblastoma

    • Research Watch
      Super-Enhancers Distinguish Medulloblastoma Subtypes
      Cancer Discov March 1 2016 6 (3) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2016-020

    • Research Watch
      Medulloblastoma Subtypes Are Distinguished by MYC–MIZ1 Interaction
      Cancer Discov March 1 2016 6 (3) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2016-010

  • Metabolism

    • Research Watch
      PI3K Promotes Glycolysis through Release of Cytoskeletal Aldolase
      Cancer Discov March 1 2016 6 (3) 229-229; DOI:10.1158/2159-8290.CD-RW2016-024

    • Research Watch
      PI5P4Kβ Is a Lipid Kinase GTP Sensor That Promotes Tumorigenesis
      Cancer Discov March 1 2016 6 (3) 225-225; DOI:10.1158/2159-8290.CD-RW2016-012

  • Structural Biology

    • Research Watch
      Phosphorylated ABRAXAS Promotes BRCA1 Accumulation at DNA Damage Sites
      Cancer Discov March 1 2016 6 (3) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2016-014

  • Correction

    • Correction
      Correction: Response to MET Inhibitors in Patients with Stage IV Lung Adenocarcinomas Harboring MET Mutations Causing Exon 14 Skipping
      Cancer Discov March 1 2016 6 (3) 330-330; DOI:10.1158/2159-8290.CD-16-0199

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Cancer Discovery: 6 (3)
March 2016
Volume 6, Issue 3
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  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
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