Table of Contents

Research Articles

• Research Articles

  Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

  Kyoung Eun Lee, Michelle Spata, Lauren J. Bayne, Elizabeth L. Buza, Amy C. Durham, David Allman, Robert H. Vonderheide and M. Celeste Simon

  Cancer Discov March 1 2016 6 (3) 256-269; DOI:10.1158/2159-8290.CD-15-0822

  
  

  HIF1α prevents PDAC initiation by suppressing protumorigenic B cell recruitment to the pancreas, which is required for PDAC progression.

• Research Articles | Free Article

  Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer

  Andrew J. Gunderson, Megan M. Kaneda, Takahiro Tsujikawa, Abraham V. Nguyen, Nesrine I. Affara, Brian Ruffell, Sara Gorjestani, Shannon M. Liudahl, Morgan Truitt, Peter Olson, Grace Kim, Douglas Hanahan, Margaret A. Tempero, Brett Sheppard, Bryan Irving, Betty Y. Chang, Judith A. Varner and Lisa M. Coussens

  Cancer Discov March 1 2016 6 (3) 270-285; DOI:10.1158/2159-8290.CD-15-0827

  
  

  Inhibition of PI3Kγ/BTK signaling between B cells and FcRγ-positive macrophages reactivates T cell–dependent immune responses and suppresses PDAC tumor growth in mice.

• Research Articles | AuthorChoice

  Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

  Maria Romina Girotti, Gabriela Gremel, Rebecca Lee, Elena Galvani, Dominic Rothwell, Amaya Viros, Amit Kumar Mandal, Kok Haw Jonathan Lim, Grazia Saturno, Simon J. Furney, Franziska Baenke, Malin Pedersen, Jane Rogan, Jacqueline Swan, Matthew Smith, Alberto Fusi, Deemesh Oudit, Nathalie Dhomen, Ged Brady, Paul Lorigan, Caroline Dive and Richard Marais

  Cancer Discov March 1 2016 6 (3) 286-299; DOI:10.1158/2159-8290.CD-15-1336

  
  

  Next-generation sequencing of circulating tumor DNA can be used to monitor response to therapy and identify potential treatment strategies, which can be validated in patient-derived or circulating tumor cell–derived xenografts.

• Research Articles

  Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120

  Shih-Hsun Chen, Youyan Zhang, Robert D. Van Horn, Tinggui Yin, Sean Buchanan, Vipin Yadav, Igor Mochalkin, Swee Seong Wong, Yong Gang Yue, Lysiane Huber, Ilaria Conti, James R. Henry, James J. Starling, Gregory D. Plowman and Sheng-Bin Peng

  Cancer Discov March 1 2016 6 (3) 300-315; DOI:10.1158/2159-8290.CD-15-0896

  
  

  Previously unidentified BRAF in-frame deletions promote the formation of homodimers, which activate MAPK signaling and are sensitive to LY3009120.

• Research Articles

  Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

  Matthew P. Patricelli, Matthew R. Janes, Lian-Sheng Li, Rasmus Hansen, Ulf Peters, Linda V. Kessler, Yuching Chen, Jeff M. Kucharski, Jun Feng, Tess Ely, Jeffrey H. Chen, Sarah J. Firdaus, Anjali Babbar, Pingda Ren and Yi Liu

  Cancer Discov March 1 2016 6 (3) 316-329; DOI:10.1158/2159-8290.CD-15-1105

  
  

  Mutant KRAS^G12C exhibits a dynamic nucleotide state that is responsive to upstream signaling, and its activation can be selectively and potently suppressed by small-molecule binding to the GDP-bound state.