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Cancer Discovery
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Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy

Stephen J. Blake, Kimberley Stannard, Jing Liu, Stacey Allen, Michelle C.R. Yong, Deepak Mittal, Amelia Roman Aguilera, John J. Miles, Viviana P. Lutzky, Lucas Ferrari de Andrade, Ludovic Martinet, Marco Colonna, Kazuyoshi Takeda, Florian Kühnel, Engin Gurlevik, Günter Bernhardt, Michele W.L. Teng and Mark J. Smyth
Stephen J. Blake
1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Kimberley Stannard
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Jing Liu
1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Stacey Allen
1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Michelle C.R. Yong
1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Deepak Mittal
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Amelia Roman Aguilera
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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John J. Miles
3Human Immunity, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
4Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
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Viviana P. Lutzky
3Human Immunity, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Lucas Ferrari de Andrade
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Ludovic Martinet
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
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Marco Colonna
5Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
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Kazuyoshi Takeda
6Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
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Florian Kühnel
7Department for Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
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Engin Gurlevik
7Department for Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
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Günter Bernhardt
8Institute of Immunology, Hannover Medical School, Hannover, Germany.
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Michele W.L. Teng
1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
9School of Medicine, The University of Queensland, Herston, Queensland, Australia.
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Mark J. Smyth
2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
9School of Medicine, The University of Queensland, Herston, Queensland, Australia.
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  • For correspondence: mark.smyth@qimrberghofer.edu.au
DOI: 10.1158/2159-8290.CD-15-0944 Published April 2016
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Cited By

Article Information

Volume 6, Issue 4, pp. 446-459

DOI 
https://doi.org/10.1158/2159-8290.CD-15-0944
PubMed 
26787820

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received August 4, 2015
  • Revision received January 12, 2016
  • Accepted January 15, 2016
  • Published first January 19, 2016.

Article Versions

  • Previous version (January 19, 2016 - 06:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Stephen J. Blake1,
  2. Kimberley Stannard2,
  3. Jing Liu1,2,
  4. Stacey Allen1,
  5. Michelle C.R. Yong1,
  6. Deepak Mittal2,
  7. Amelia Roman Aguilera2,
  8. John J. Miles3,4,
  9. Viviana P. Lutzky3,
  10. Lucas Ferrari de Andrade2,
  11. Ludovic Martinet2,
  12. Marco Colonna5,
  13. Kazuyoshi Takeda6,
  14. Florian Kühnel7,
  15. Engin Gurlevik7,
  16. Günter Bernhardt8,
  17. Michele W.L. Teng1,9 and
  18. Mark J. Smyth2,9,*
  1. 1Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  2. 2Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  3. 3Human Immunity, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  4. 4Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
  5. 5Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
  6. 6Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
  7. 7Department for Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
  8. 8Institute of Immunology, Hannover Medical School, Hannover, Germany.
  9. 9School of Medicine, The University of Queensland, Herston, Queensland, Australia.
  1. ↵*Corresponding Author:
    Mark J. Smyth, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston 4006, Australia. Phone: 61-7-3845-3957; Fax: 61-7-3362-0111; E-mail: mark.smyth{at}qimrberghofer.edu.au
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Cancer Discovery: 6 (4)
April 2016
Volume 6, Issue 4
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Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy
Stephen J. Blake, Kimberley Stannard, Jing Liu, Stacey Allen, Michelle C.R. Yong, Deepak Mittal, Amelia Roman Aguilera, John J. Miles, Viviana P. Lutzky, Lucas Ferrari de Andrade, Ludovic Martinet, Marco Colonna, Kazuyoshi Takeda, Florian Kühnel, Engin Gurlevik, Günter Bernhardt, Michele W.L. Teng and Mark J. Smyth
Cancer Discov April 1 2016 (6) (4) 446-459; DOI: 10.1158/2159-8290.CD-15-0944

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Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy
Stephen J. Blake, Kimberley Stannard, Jing Liu, Stacey Allen, Michelle C.R. Yong, Deepak Mittal, Amelia Roman Aguilera, John J. Miles, Viviana P. Lutzky, Lucas Ferrari de Andrade, Ludovic Martinet, Marco Colonna, Kazuyoshi Takeda, Florian Kühnel, Engin Gurlevik, Günter Bernhardt, Michele W.L. Teng and Mark J. Smyth
Cancer Discov April 1 2016 (6) (4) 446-459; DOI: 10.1158/2159-8290.CD-15-0944
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