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Cancer Discovery
Cancer Discovery

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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2016 6 (5) 461-463; DOI:10.1158/2159-8290.CD-ITI6-5

In the Spotlight

  • In the Spotlight
    MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis
    Miguel Santiago-Medina and Jing Yang
    Cancer Discov May 1 2016 6 (5) 474-476; DOI:10.1158/2159-8290.CD-16-0231

  • In the Spotlight
    PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment
    Zhenhua Ren, Hua Peng and Yang-Xin Fu
    Cancer Discov May 1 2016 6 (5) 477-478; DOI:10.1158/2159-8290.CD-16-0307

Review

  • Reviews
    Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
    Catherine Alix-Panabières and Klaus Pantel
    Cancer Discov May 1 2016 6 (5) 479-491; DOI:10.1158/2159-8290.CD-15-1483

Research Briefs

  • Research Briefs
    Clinical Response of Carcinomas Harboring the BRD4–NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628
    Anastasios Stathis, Emanuele Zucca, Mohamed Bekradda, Carlos Gomez-Roca, Jean-Pierre Delord, Thibault de La Motte Rouge, Emmanuelle Uro-Coste, Filippo de Braud, Giuseppe Pelosi and Christopher A. French
    Cancer Discov May 1 2016 6 (5) 492-500; DOI:10.1158/2159-8290.CD-15-1335

    Four patients with NMC harboring BRD4–NUT fusion protein were compassionately treated with the BET inhibitor OTX015/MK-8628, resulting in two rapid responses and one disease stabilization, and two patients achieved extended overall survival post-diagnosis.

  • Research Briefs | AuthorChoice
    DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia
    Sara E. Meyer, Tingting Qin, David E. Muench, Kohei Masuda, Meenakshi Venkatasubramanian, Emily Orr, Lauren Suarez, Steven D. Gore, Ruud Delwel, Elisabeth Paietta, Martin S. Tallman, Hugo Fernandez, Ari Melnick, Michelle M. Le Beau, Scott Kogan, Nathan Salomonis, Maria E. Figueroa and H. Leighton Grimes
    Cancer Discov May 1 2016 6 (5) 501-515; DOI:10.1158/2159-8290.CD-16-0008

    In a mouse model harboring FLT3 internal-tandem duplication, DNMT3A haploinsufficiency disrupts methylation of methylation-sensitive genes, resulting in fully penetrant acute myeloid leukemia.

Research Articles

  • Research Articles
    Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression
    Madeleine J. Oudin, Oliver Jonas, Tatsiana Kosciuk, Liliane C. Broye, Bruna C. Guido, Jeff Wyckoff, Daisy Riquelme, John M. Lamar, Sreeja B. Asokan, Charlie Whittaker, Duanduan Ma, Robert Langer, Michael J. Cima, Kari B. Wisinski, Richard O. Hynes, Douglas A. Lauffenburger, Patricia J. Keely, James E. Bear and Frank B. Gertler
    Cancer Discov May 1 2016 6 (5) 516-531; DOI:10.1158/2159-8290.CD-15-1183

    An alternatively spliced form of the actin-associated protein MENA, MENAINV, associates with integrin α5β1 to induce migration toward high fibronectin concentrations and promote metastasis.

  • Research Articles
    Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
    Kristina M. Godek, Monica Venere, Quilian Wu, Kevin D. Mills, William F. Hickey, Jeremy N. Rich and Duane A. Compton
    Cancer Discov May 1 2016 6 (5) 532-545; DOI:10.1158/2159-8290.CD-15-1154

    Glioblastoma tumor-initiating cells are a source of intratumor genetic heterogeneity due to chromosomal instability; however, further elevation of chromosomal instability results in reduced proliferation, self-renewal, and tumor-initiating properties in these cells.

  • Research Articles
    PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression
    Xiao Xiao, Xiang-Ming Lao, Min-Min Chen, Rui-Xian Liu, Yuan Wei, Fang-Zhu Ouyang, Dong-Ping Chen, Xiao-Yu Zhao, Qiyi Zhao, Xue-Feng Li, Chuan-Lu Liu, Limin Zheng and Dong-Ming Kuang
    Cancer Discov May 1 2016 6 (5) 546-559; DOI:10.1158/2159-8290.CD-15-1408

    Subsets of B cells in human HCC undergo TLR4/BCL6-mediated induction of PD-1 and promote IL10-dependent T-cell dysfunction upon interaction with PD-L1+ monocytes.

News in Brief

  • News in Brief
    People
    Cancer Discov May 1 2016 6 (5) 464-464; DOI:10.1158/2159-8290.CD-NB2016-031

  • News in Brief
    Project Data Sphere Takes Off
    Cancer Discov May 1 2016 6 (5) 464-464; DOI:10.1158/2159-8290.CD-NB2016-035

  • News in Brief
    Pediatric Glioblastoma Model Suggests Treatments
    Cancer Discov May 1 2016 6 (5) 465-465; DOI:10.1158/2159-8290.CD-NB2016-036

  • News in Brief
    Proposed NIH Budget Includes Mandatory Funding
    Cancer Discov May 1 2016 6 (5) 465-466; DOI:10.1158/2159-8290.CD-NB2016-027

  • News in Brief
    Metastatic Sites Predict Prostate Cancer Survival
    Cancer Discov May 1 2016 6 (5) 466-466; DOI:10.1158/2159-8290.CD-NB2016-032

  • News in Brief
    Inflammation May Activate Antitumor Mechanism
    Cancer Discov May 1 2016 6 (5) 466-467; DOI:10.1158/2159-8290.CD-NB2016-024

  • News in Brief
    Analysis of ALL Subtypes May Improve Treatment
    Cancer Discov May 1 2016 6 (5) 467-468; DOI:10.1158/2159-8290.CD-NB2016-025

  • News in Brief
    Diagnostic Advances Made for CNS-PNET
    Cancer Discov May 1 2016 6 (5) 468-468; DOI:10.1158/2159-8290.CD-NB2016-029

  • News in Brief
    Noted
    Cancer Discov May 1 2016 6 (5) 468-468; DOI:10.1158/2159-8290.CD-NB2016-030

  • News in Brief
    Study May Change Approach to Immunotherapy
    Cancer Discov May 1 2016 6 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2016-034

  • News in Brief
    Expanding the Genetic Profile of BCC
    Cancer Discov May 1 2016 6 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2016-033

  • News in Brief
    Breast Cancer Risk Variants Affect Estrogen Receptor
    Cancer Discov May 1 2016 6 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2016-028

Research Watch

  • Breast Cancer

    • Research Watch
      CDK4/6 Inhibition Overcomes Drug Resistance in HER2+ Breast Cancer
      Cancer Discov May 1 2016 6 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-RW2016-054

    • Research Watch
      MYC-Overexpressing TNBCs Depend on Fatty Acid Oxidation
      Cancer Discov May 1 2016 6 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2016-049

    • Research Watch
      Milk Duct Engraftment Allows Preclinical Modeling of ER+ Breast Cancer
      Cancer Discov May 1 2016 6 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2016-050

  • Clinical Trials

    • Research Watch
      Pictilisib Plus Anastrozole Reduces Proliferation in ER+ Breast Cancer
      Cancer Discov May 1 2016 6 (5) 471-471; DOI:10.1158/2159-8290.CD-RW2016-055

  • Genomics

    • Research Watch
      A Set of Transcriptomic Changes Is Associated with Anti–PD-1 Resistance
      Cancer Discov May 1 2016 6 (5) 472-472; DOI:10.1158/2159-8290.CD-RW2016-057

  • Glioblastoma

    • Research Watch
      Immune Checkpoint Inhibition Is Effective in Hypermutant Glioblastoma
      Cancer Discov May 1 2016 6 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2016-060

  • Hepatocellular Carcinoma

    • Research Watch
      Hepatic Deletion of AKT1 and AKT2 Induces Hepatocellular Carcinoma
      Cancer Discov May 1 2016 6 (5) 473-473; DOI:10.1158/2159-8290.CD-RW2016-056

    • Research Watch
      CD4+ T Cell Loss Drives NAFLD Progression to Hepatocellular Carcinoma
      Cancer Discov May 1 2016 6 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2016-046

  • Immune Evasion

    • Research Watch
      MYC Promotes Tumorigenesis via Activation of CD47 and PD-L1
      Cancer Discov May 1 2016 6 (5) 472-472; DOI:10.1158/2159-8290.CD-RW2016-051

  • Invasion

    • Research Watch
      Schwann Cells Promote Cancer Cell Invasion
      Cancer Discov May 1 2016 6 (5) 473-473; DOI:10.1158/2159-8290.CD-RW2016-059

  • Leukemia

    • Research Watch
      Recurrent Fusions Distinguish Adolescent and Young Adult ALL
      Cancer Discov May 1 2016 6 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2016-065

  • Medulloblastoma

    • Research Watch
      Targeting HDAC And PI3K Inhibits MYC-Driven Medulloblastoma Growth
      Cancer Discov May 1 2016 6 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2016-052

  • Melanoma

    • Research Watch
      SAMMSON Long Noncoding RNA Is Essential for Melanoma Cell Viability
      Cancer Discov May 1 2016 6 (5) 470-470; DOI:10.1158/2159-8290.CD-RW2016-062

    • Research Watch
      MITF Drives a Reversible Drug-Tolerant State in Melanoma
      Cancer Discov May 1 2016 6 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2016-053

  • Metabolism

    • Research Watch
      mTORC1 Signaling Allows Cancer Cells to Escape Glycolytic Dependency
      Cancer Discov May 1 2016 6 (5) 469-469; DOI:10.1158/2159-8290.CD-RW2016-063

    • Research Watch
      A High-Fat Diet Promotes Intestinal Stemness and Tumorigenesis
      Cancer Discov May 1 2016 6 (5) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2016-048

  • Metastasis

    • Research Watch
      Autocrine WNT Inhibition Drives Immune Evasion and Latency of Metastases
      Cancer Discov May 1 2016 6 (5) 471-471; DOI:10.1158/2159-8290.CD-RW2016-061

  • Prostate Cancer

    • Research Watch
      Prostate Cancer Risk Loci Are Associated with Gene Regulatory Mechanisms
      Cancer Discov May 1 2016 6 (5) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2016-047

  • Signal Transduction

    • Research Watch
      Lipids Regulate SH2-Mediated Protein–Protein Interactions and Signaling
      Cancer Discov May 1 2016 6 (5) 469-469; DOI:10.1158/2159-8290.CD-RW2016-064

  • Tumor Suppressors

    • Research Watch
      TP53 Is Not the Only Driver of Chromosome 17p Loss
      Cancer Discov May 1 2016 6 (5) 470-470; DOI:10.1158/2159-8290.CD-RW2016-058

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Cancer Discovery: 6 (5)
May 2016
Volume 6, Issue 5
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    • Glioblastoma
    • Hepatocellular Carcinoma
    • Immune Evasion
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    • Medulloblastoma
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Cancer Discovery
eISSN: 2159-8290
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