Table of Contents
In This Issue
In the Spotlight
- In the SpotlightMiguel Santiago-Medina and Jing YangCancer Discov May 1 2016 6 (5) 474-476; DOI:10.1158/2159-8290.CD-16-0231
- In the SpotlightZhenhua Ren, Hua Peng and Yang-Xin FuCancer Discov May 1 2016 6 (5) 477-478; DOI:10.1158/2159-8290.CD-16-0307
Review
- ReviewsCatherine Alix-Panabières and Klaus PantelCancer Discov May 1 2016 6 (5) 479-491; DOI:10.1158/2159-8290.CD-15-1483
Research Briefs
- Research BriefsAnastasios Stathis, Emanuele Zucca, Mohamed Bekradda, Carlos Gomez-Roca, Jean-Pierre Delord, Thibault de La Motte Rouge, Emmanuelle Uro-Coste, Filippo de Braud, Giuseppe Pelosi and Christopher A. FrenchCancer Discov May 1 2016 6 (5) 492-500; DOI:10.1158/2159-8290.CD-15-1335
Four patients with NMC harboring BRD4–NUT fusion protein were compassionately treated with the BET inhibitor OTX015/MK-8628, resulting in two rapid responses and one disease stabilization, and two patients achieved extended overall survival post-diagnosis.
- Research Briefs | AuthorChoiceSara E. Meyer, Tingting Qin, David E. Muench, Kohei Masuda, Meenakshi Venkatasubramanian, Emily Orr, Lauren Suarez, Steven D. Gore, Ruud Delwel, Elisabeth Paietta, Martin S. Tallman, Hugo Fernandez, Ari Melnick, Michelle M. Le Beau, Scott Kogan, Nathan Salomonis, Maria E. Figueroa and H. Leighton GrimesCancer Discov May 1 2016 6 (5) 501-515; DOI:10.1158/2159-8290.CD-16-0008
In a mouse model harboring FLT3 internal-tandem duplication, DNMT3A haploinsufficiency disrupts methylation of methylation-sensitive genes, resulting in fully penetrant acute myeloid leukemia.
Research Articles
- Research ArticlesMadeleine J. Oudin, Oliver Jonas, Tatsiana Kosciuk, Liliane C. Broye, Bruna C. Guido, Jeff Wyckoff, Daisy Riquelme, John M. Lamar, Sreeja B. Asokan, Charlie Whittaker, Duanduan Ma, Robert Langer, Michael J. Cima, Kari B. Wisinski, Richard O. Hynes, Douglas A. Lauffenburger, Patricia J. Keely, James E. Bear and Frank B. GertlerCancer Discov May 1 2016 6 (5) 516-531; DOI:10.1158/2159-8290.CD-15-1183
An alternatively spliced form of the actin-associated protein MENA, MENAINV, associates with integrin α5β1 to induce migration toward high fibronectin concentrations and promote metastasis.
- Research ArticlesKristina M. Godek, Monica Venere, Quilian Wu, Kevin D. Mills, William F. Hickey, Jeremy N. Rich and Duane A. ComptonCancer Discov May 1 2016 6 (5) 532-545; DOI:10.1158/2159-8290.CD-15-1154
Glioblastoma tumor-initiating cells are a source of intratumor genetic heterogeneity due to chromosomal instability; however, further elevation of chromosomal instability results in reduced proliferation, self-renewal, and tumor-initiating properties in these cells.
- Research ArticlesXiao Xiao, Xiang-Ming Lao, Min-Min Chen, Rui-Xian Liu, Yuan Wei, Fang-Zhu Ouyang, Dong-Ping Chen, Xiao-Yu Zhao, Qiyi Zhao, Xue-Feng Li, Chuan-Lu Liu, Limin Zheng and Dong-Ming KuangCancer Discov May 1 2016 6 (5) 546-559; DOI:10.1158/2159-8290.CD-15-1408
Subsets of B cells in human HCC undergo TLR4/BCL6-mediated induction of PD-1 and promote IL10-dependent T-cell dysfunction upon interaction with PD-L1+ monocytes.
News in Brief
- News in BriefCancer Discov May 1 2016 6 (5) 464-464; DOI:10.1158/2159-8290.CD-NB2016-035
- News in BriefCancer Discov May 1 2016 6 (5) 465-465; DOI:10.1158/2159-8290.CD-NB2016-036
- News in BriefCancer Discov May 1 2016 6 (5) 465-466; DOI:10.1158/2159-8290.CD-NB2016-027
- News in BriefCancer Discov May 1 2016 6 (5) 466-466; DOI:10.1158/2159-8290.CD-NB2016-032
- News in BriefCancer Discov May 1 2016 6 (5) 466-467; DOI:10.1158/2159-8290.CD-NB2016-024
- News in BriefCancer Discov May 1 2016 6 (5) 467-468; DOI:10.1158/2159-8290.CD-NB2016-025
- News in BriefCancer Discov May 1 2016 6 (5) 468-468; DOI:10.1158/2159-8290.CD-NB2016-029
- News in BriefCancer Discov May 1 2016 6 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2016-034
- News in BriefCancer Discov May 1 2016 6 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2016-033
- News in BriefCancer Discov May 1 2016 6 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2016-028
Research Watch
Breast Cancer
- Research WatchCancer Discov May 1 2016 6 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-RW2016-054
- Research WatchCancer Discov May 1 2016 6 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2016-049
- Research WatchCancer Discov May 1 2016 6 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2016-050
Clinical Trials
- Research WatchCancer Discov May 1 2016 6 (5) 471-471; DOI:10.1158/2159-8290.CD-RW2016-055
Genomics
- Research WatchCancer Discov May 1 2016 6 (5) 472-472; DOI:10.1158/2159-8290.CD-RW2016-057
Glioblastoma
- Research WatchCancer Discov May 1 2016 6 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2016-060
Hepatocellular Carcinoma
- Research WatchCancer Discov May 1 2016 6 (5) 473-473; DOI:10.1158/2159-8290.CD-RW2016-056
- Research WatchCancer Discov May 1 2016 6 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2016-046
Immune Evasion
- Research WatchCancer Discov May 1 2016 6 (5) 472-472; DOI:10.1158/2159-8290.CD-RW2016-051
Invasion
- Research WatchCancer Discov May 1 2016 6 (5) 473-473; DOI:10.1158/2159-8290.CD-RW2016-059
Leukemia
- Research WatchCancer Discov May 1 2016 6 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2016-065
Medulloblastoma
- Research WatchCancer Discov May 1 2016 6 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2016-052
Melanoma
- Research WatchCancer Discov May 1 2016 6 (5) 470-470; DOI:10.1158/2159-8290.CD-RW2016-062
- Research WatchCancer Discov May 1 2016 6 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2016-053
Metabolism
- Research WatchCancer Discov May 1 2016 6 (5) 469-469; DOI:10.1158/2159-8290.CD-RW2016-063
- Research WatchCancer Discov May 1 2016 6 (5) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2016-048
Metastasis
- Research WatchCancer Discov May 1 2016 6 (5) 471-471; DOI:10.1158/2159-8290.CD-RW2016-061
Prostate Cancer
- Research WatchCancer Discov May 1 2016 6 (5) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2016-047
Signal Transduction
- Research WatchCancer Discov May 1 2016 6 (5) 469-469; DOI:10.1158/2159-8290.CD-RW2016-064
Tumor Suppressors
- Research WatchCancer Discov May 1 2016 6 (5) 470-470; DOI:10.1158/2159-8290.CD-RW2016-058
Volume 6, Issue 5
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