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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2016 6 (5) 461-463; DOI:10.1158/2159-8290.CD-ITI6-5

In the Spotlight

Review

Research Briefs

  • Research Briefs
    Clinical Response of Carcinomas Harboring the BRD4–NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628
    Anastasios Stathis, Emanuele Zucca, Mohamed Bekradda, Carlos Gomez-Roca, Jean-Pierre Delord, Thibault de La Motte Rouge, Emmanuelle Uro-Coste, Filippo de Braud, Giuseppe Pelosi and Christopher A. French
    Cancer Discov May 1 2016 6 (5) 492-500; DOI:10.1158/2159-8290.CD-15-1335

    Four patients with NMC harboring BRD4–NUT fusion protein were compassionately treated with the BET inhibitor OTX015/MK-8628, resulting in two rapid responses and one disease stabilization, and two patients achieved extended overall survival post-diagnosis.

  • Research Briefs | AuthorChoice
    DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia
    Sara E. Meyer, Tingting Qin, David E. Muench, Kohei Masuda, Meenakshi Venkatasubramanian, Emily Orr, Lauren Suarez, Steven D. Gore, Ruud Delwel, Elisabeth Paietta, Martin S. Tallman, Hugo Fernandez, Ari Melnick, Michelle M. Le Beau, Scott Kogan, Nathan Salomonis, Maria E. Figueroa and H. Leighton Grimes
    Cancer Discov May 1 2016 6 (5) 501-515; DOI:10.1158/2159-8290.CD-16-0008

    In a mouse model harboring FLT3 internal-tandem duplication, DNMT3A haploinsufficiency disrupts methylation of methylation-sensitive genes, resulting in fully penetrant acute myeloid leukemia.

Research Articles

  • Research Articles
    Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression
    Madeleine J. Oudin, Oliver Jonas, Tatsiana Kosciuk, Liliane C. Broye, Bruna C. Guido, Jeff Wyckoff, Daisy Riquelme, John M. Lamar, Sreeja B. Asokan, Charlie Whittaker, Duanduan Ma, Robert Langer, Michael J. Cima, Kari B. Wisinski, Richard O. Hynes, Douglas A. Lauffenburger, Patricia J. Keely, James E. Bear and Frank B. Gertler
    Cancer Discov May 1 2016 6 (5) 516-531; DOI:10.1158/2159-8290.CD-15-1183

    An alternatively spliced form of the actin-associated protein MENA, MENAINV, associates with integrin α5β1 to induce migration toward high fibronectin concentrations and promote metastasis.

  • Research Articles
    Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
    Kristina M. Godek, Monica Venere, Quilian Wu, Kevin D. Mills, William F. Hickey, Jeremy N. Rich and Duane A. Compton
    Cancer Discov May 1 2016 6 (5) 532-545; DOI:10.1158/2159-8290.CD-15-1154

    Glioblastoma tumor-initiating cells are a source of intratumor genetic heterogeneity due to chromosomal instability; however, further elevation of chromosomal instability results in reduced proliferation, self-renewal, and tumor-initiating properties in these cells.

  • Research Articles
    PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression
    Xiao Xiao, Xiang-Ming Lao, Min-Min Chen, Rui-Xian Liu, Yuan Wei, Fang-Zhu Ouyang, Dong-Ping Chen, Xiao-Yu Zhao, Qiyi Zhao, Xue-Feng Li, Chuan-Lu Liu, Limin Zheng and Dong-Ming Kuang
    Cancer Discov May 1 2016 6 (5) 546-559; DOI:10.1158/2159-8290.CD-15-1408

    Subsets of B cells in human HCC undergo TLR4/BCL6-mediated induction of PD-1 and promote IL10-dependent T-cell dysfunction upon interaction with PD-L1+ monocytes.

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Cancer Discovery: 6 (5)
May 2016
Volume 6, Issue 5

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