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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer

Hidenori Kitai, Hiromichi Ebi, Shuta Tomida, Konstantinos V. Floros, Hiroshi Kotani, Yuta Adachi, Satoshi Oizumi, Masaharu Nishimura, Anthony C. Faber and Seiji Yano
Hidenori Kitai
1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
2First Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.
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Hiromichi Ebi
1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
3Institute for Frontier Science Initiative, Kanazawa University, Ishikawa, Japan.
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  • For correspondence: hebi@staff.kanazawa-u.ac.jp syano@staff.kanazawa-u.ac.jp
Shuta Tomida
4Department of Biobank, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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Konstantinos V. Floros
5VCU Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
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Hiroshi Kotani
1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
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Yuta Adachi
1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
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Satoshi Oizumi
2First Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.
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Masaharu Nishimura
2First Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.
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Anthony C. Faber
5VCU Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
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Seiji Yano
1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
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  • For correspondence: hebi@staff.kanazawa-u.ac.jp syano@staff.kanazawa-u.ac.jp
DOI: 10.1158/2159-8290.CD-15-1377 Published July 2016
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ARTICLE USAGE: May 2016 to January 2021

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Article Information

Volume 6, Issue 7, pp. 754-769

DOI 
https://doi.org/10.1158/2159-8290.CD-15-1377
PubMed 
27154822

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received November 19, 2015
  • Revision received May 4, 2016
  • Accepted May 4, 2016
  • Published first May 6, 2016.

Article Versions

  • Previous version (May 6, 2016 - 06:22).
  • Previous version (June 20, 2016 - 07:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Hidenori Kitai1,2,
  2. Hiromichi Ebi1,3,*,
  3. Shuta Tomida4,
  4. Konstantinos V. Floros5,
  5. Hiroshi Kotani1,
  6. Yuta Adachi1,
  7. Satoshi Oizumi2,
  8. Masaharu Nishimura2,
  9. Anthony C. Faber5 and
  10. Seiji Yano1,*
  1. 1Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
  2. 2First Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.
  3. 3Institute for Frontier Science Initiative, Kanazawa University, Ishikawa, Japan.
  4. 4Department of Biobank, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
  5. 5VCU Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
  1. ↵*Corresponding Authors:
    Hiromichi Ebi, Institute for Frontier Science Initiative, and Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1, Takaramachi, Kanazawa, Ishikawa 920-0934, Japan. Phone: 81-76-265-2794; Fax: 81-76-234-4524; E-mail: hebi{at}staff.kanazawa-u.ac.jp; and Seiji Yano, E-mail: syano{at}staff.kanazawa-u.ac.jp
  1. H. Kitai and H. Ebi contributed equally to this article.

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Cancer Discovery: 6 (7)
July 2016
Volume 6, Issue 7
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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer
Hidenori Kitai, Hiromichi Ebi, Shuta Tomida, Konstantinos V. Floros, Hiroshi Kotani, Yuta Adachi, Satoshi Oizumi, Masaharu Nishimura, Anthony C. Faber and Seiji Yano
Cancer Discov July 1 2016 (6) (7) 754-769; DOI: 10.1158/2159-8290.CD-15-1377

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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer
Hidenori Kitai, Hiromichi Ebi, Shuta Tomida, Konstantinos V. Floros, Hiroshi Kotani, Yuta Adachi, Satoshi Oizumi, Masaharu Nishimura, Anthony C. Faber and Seiji Yano
Cancer Discov July 1 2016 (6) (7) 754-769; DOI: 10.1158/2159-8290.CD-15-1377
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