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Cancer Discovery

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Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

Jessica S. Brown, Brent O'Carrigan, Stephen P. Jackson and Timothy A. Yap
Jessica S. Brown
Royal Marsden NHS Foundation Trust, London, United Kingdom.
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Brent O'Carrigan
Royal Marsden NHS Foundation Trust, London, United Kingdom.
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Stephen P. Jackson
The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
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Timothy A. Yap
Royal Marsden NHS Foundation Trust, London, United Kingdom.The Institute of Cancer Research, London, United Kingdom.
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  • For correspondence: timothy.yap@icr.ac.uk
DOI: 10.1158/2159-8290.CD-16-0860 Published January 2017
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Article Information

Volume 7, Issue 1, pp. 20-37

DOI 
https://doi.org/10.1158/2159-8290.CD-16-0860
PubMed 
28003236

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received August 3, 2016
  • Revision received November 3, 2016
  • Accepted November 7, 2016
  • Published first December 21, 2016.

Article Versions

  • Previous version (December 21, 2016 - 05:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Jessica S. Brown1,
  2. Brent O'Carrigan1,
  3. Stephen P. Jackson2,3 and
  4. Timothy A. Yap1,4,*
  1. 1Royal Marsden NHS Foundation Trust, London, United Kingdom.
  2. 2The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
  3. 3The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
  4. 4The Institute of Cancer Research, London, United Kingdom.
  1. ↵*Corresponding Author:
    Timothy A. Yap, Drug Development Unit, Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, London SM2 5PT, United Kingdom. Phone: 44-20-8661-3539; Fax: 44-20-8642-7979; E-mail: timothy.yap{at}icr.ac.uk
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Cancer Discovery: 7 (1)
January 2017
Volume 7, Issue 1
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Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
Jessica S. Brown, Brent O'Carrigan, Stephen P. Jackson and Timothy A. Yap
Cancer Discov January 1 2017 (7) (1) 20-37; DOI: 10.1158/2159-8290.CD-16-0860

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Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
Jessica S. Brown, Brent O'Carrigan, Stephen P. Jackson and Timothy A. Yap
Cancer Discov January 1 2017 (7) (1) 20-37; DOI: 10.1158/2159-8290.CD-16-0860
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  • Article
    • Abstract
    • Introduction
    • Targeting of DNA-Damage Sensor Proteins
    • Targeting of DNA-Damage Signaling Proteins
    • Targeting of DDR Effector Proteins and Repair Pathways
    • Fine-Tuning the DDR
    • Patient Selection
    • Combination Strategies
    • Future Perspectives and Conclusions
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
    • References
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