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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov December 1 2017 7 (12) 1355-1357; DOI:10.1158/2159-8290.CD-ITI7-12

In the Spotlight

  • In the Spotlight
    Predicting Relapse with Circulating Tumor DNA Analysis in Lung Cancer
    Iñaki Comino-Mendez and Nicholas Turner
    Cancer Discov December 1 2017 7 (12) 1368-1370; DOI:10.1158/2159-8290.CD-17-1086

  • In the Spotlight
    CNS Endothelial Cell Activation Emerges as a Driver of CAR T Cell–Associated Neurotoxicity
    Crystal L. Mackall and David B. Miklos
    Cancer Discov December 1 2017 7 (12) 1371-1373; DOI:10.1158/2159-8290.CD-17-1084

  • In the Spotlight
    Losers of Primary Cilia Gain the Benefit of Survival
    Gladiola Goranci-Buzhala, Elke Gabriel, Aruljothi Mariappan and Jay Gopalakrishnan
    Cancer Discov December 1 2017 7 (12) 1374-1375; DOI:10.1158/2159-8290.CD-17-1085

Review

  • Review | AuthorChoice
    Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
    Joel D. Leverson, Deepak Sampath, Andrew J. Souers, Saul H. Rosenberg, Wayne J. Fairbrother, Martine Amiot, Marina Konopleva and Anthony Letai
    Cancer Discov December 1 2017 7 (12) 1376-1393; DOI:10.1158/2159-8290.CD-17-0797

Research Brief

  • Research Brief
    Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling
    Aadel A. Chaudhuri, Jacob J. Chabon, Alexander F. Lovejoy, Aaron M. Newman, Henning Stehr, Tej D. Azad, Michael S. Khodadoust, Mohammad Shahrokh Esfahani, Chih Long Liu, Li Zhou, Florian Scherer, David M. Kurtz, Carmen Say, Justin N. Carter, David J. Merriott, Jonathan C. Dudley, Michael S. Binkley, Leslie Modlin, Sukhmani K. Padda, Michael F. Gensheimer, Robert B. West, Joseph B. Shrager, Joel W. Neal, Heather A. Wakelee, Billy W. Loo Jr, Ash A. Alizadeh and Maximilian Diehn
    Cancer Discov December 1 2017 7 (12) 1394-1403; DOI:10.1158/2159-8290.CD-17-0716

    ctDNA profiling of pre- and post-treatment samples from patients with localized lung cancer identifies the presence of minimal residual disease earlier than standard imaging.

Research Articles

  • Research Articles
    Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells
    Juliane Gust, Kevin A. Hay, Laïla-Aïcha Hanafi, Daniel Li, David Myerson, Luis F. Gonzalez-Cuyar, Cecilia Yeung, W. Conrad Liles, Mark Wurfel, Jose A. Lopez, Junmei Chen, Dominic Chung, Susanna Harju-Baker, Tahsin Özpolat, Kathleen R. Fink, Stanley R. Riddell, David G. Maloney and Cameron J. Turtle
    Cancer Discov December 1 2017 7 (12) 1404-1419; DOI:10.1158/2159-8290.CD-17-0698

    Endothelial activation and vascular disruption were associated with a high risk of severe neurotoxicity in 133 patients with B-cell malignancies treated with CD19-targeted CAR-T cell therapy.

  • Research Articles
    Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
    Scott Gettinger, Jungmin Choi, Katherine Hastings, Anna Truini, Ila Datar, Ryan Sowell, Anna Wurtz, Weilai Dong, Guoping Cai, Mary Ann Melnick, Victor Y. Du, Joseph Schlessinger, Sarah B. Goldberg, Anne Chiang, Miguel F. Sanmamed, Ignacio Melero, Jackeline Agorreta, Luis M. Montuenga, Richard Lifton, Soldano Ferrone, Paula Kavathas, David L. Rimm, Susan M. Kaech, Kurt Schalper, Roy S. Herbst and Katerina Politi
    Cancer Discov December 1 2017 7 (12) 1420-1435; DOI:10.1158/2159-8290.CD-17-0593

    Analysis of immune checkpoint inhibitor–resistant lung tumors revealed that loss of B2M expression may impair antigen processing to promote acquired resistance in patients with lung cancer.

  • Research Articles
    A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
    Xuesong Zhao, Ekaterina Pak, Kimberly J. Ornell, Maria F. Pazyra-Murphy, Ethan L. MacKenzie, Emily J. Chadwick, Tatyana Ponomaryov, Joseph F. Kelleher and Rosalind A. Segal
    Cancer Discov December 1 2017 7 (12) 1436-1449; DOI:10.1158/2159-8290.CD-17-0281

    Mutations that result in loss of primary cilia promote resistance to SMO inhibitors by eliminating formation of the GLI2 repressor form, allowing persistent low-level activation of hedgehog signaling.

  • Research Articles | AuthorChoice
    mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors
    Clare F. Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin L. Liu, Franziska Michor, Marcia Haigis, Kay F. Macleod, Ophélia Maertens and Karen Cichowski
    Cancer Discov December 1 2017 7 (12) 1450-1463; DOI:10.1158/2159-8290.CD-17-0177

    Combined treatment with mTOR and HDAC inhibitors cooperatively suppresses thioredoxin to trigger excessive oxidative stress and induce cell death in NF1- and KRAS-mutant tumors

  • Research Articles
    Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers
    Laetitia Seguin, Maria F. Camargo, Hiromi I. Wettersten, Shumei Kato, Jay S. Desgrosellier, Tami von Schalscha, Kathryn C. Elliott, Erika Cosset, Jacqueline Lesperance, Sara M. Weis and David A. Cheresh
    Cancer Discov December 1 2017 7 (12) 1464-1479; DOI:10.1158/2159-8290.CD-17-0539

    Inhibiting galectin-3 disrupts its interaction with integrin αvβ3, preventing the association with mutant KRAS to reduce macropinocytosis, increase ROS, and suppress KRAS-mutant tumor growth and progression.

News in Brief

  • News in Brief
    Cancer “Clock” Opens New Therapeutic Avenues
    Cancer Discov December 1 2017 7 (12) 1358-1358; DOI:10.1158/2159-8290.CD-NB2017-149

  • News in Brief
    Making Bryostatin 1 through Smart Chemistry
    Cancer Discov December 1 2017 7 (12) 1358-1359; DOI:10.1158/2159-8290.CD-NB2017-148

  • News in Brief
    Subtypes of Pediatric High-Grade Gliomas ID'd
    Cancer Discov December 1 2017 7 (12) 1359-1360; DOI:10.1158/2159-8290.CD-NB2017-145

  • News in Brief
    Xenografts Evolve Differently than Tumors
    Cancer Discov December 1 2017 7 (12) 1360-1360; DOI:10.1158/2159-8290.CD-NB2017-151

  • News in Brief
    Lorlatinib in NSCLC: Robust Efficacy Seen
    Cancer Discov December 1 2017 7 (12) 1360-1361; DOI:10.1158/2159-8290.CD-NB2017-153

  • News in Brief
    Mutation Load Offers Biomarker in SCLC
    Cancer Discov December 1 2017 7 (12) 1361-1361; DOI:10.1158/2159-8290.CD-NB2017-154

  • News in Brief
    Germline Testing Could Help More Patients
    Cancer Discov December 1 2017 7 (12) 1361-1362; DOI:10.1158/2159-8290.CD-NB2017-144

  • News in Brief
    Noted
    Cancer Discov December 1 2017 7 (12) 1362-1362; DOI:10.1158/2159-8290.CD-NB2017-142

  • News in Brief
    FDA Disperses $22 Million for Rare Diseases
    Cancer Discov December 1 2017 7 (12) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2017-150

  • News in Brief
    Copanlisib Produces Prolonged Responses in Lymphoma
    Cancer Discov December 1 2017 7 (12) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2017-147

  • News in Brief
    Obinutuzumab Effective in Follicular Lymphoma, but at a Cost
    Cancer Discov December 1 2017 7 (12) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2017-146

  • News in Brief
    NIH Funds Pediatric Data Resource Center
    Cancer Discov December 1 2017 7 (12) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2017-130

Research Watch

  • Clinical Trials

    • Research Watch
      Lorlatinib Is Well Tolerated and Has Activity in ALK+ and ROS1+ NSCLC
      Cancer Discov December 1 2017 7 (12) 1364-1364; DOI:10.1158/2159-8290.CD-RW2017-210

    • Research Watch
      Trastuzumab Deruxtecan Is Safe and Active in HER2-Expressing Tumors
      Cancer Discov December 1 2017 7 (12) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2017-202

    • Research Watch
      Pembrolizumab May Be Beneficial in a Subset of Soft-Tissue Sarcomas
      Cancer Discov December 1 2017 7 (12) 1363-1363; DOI:10.1158/2159-8290.CD-RW2017-196

  • DNA Repair

    • Research Watch
      BRCA1–BARD1 Activates RAD51 for DNA Repair by Homologous Recombination
      Cancer Discov December 1 2017 7 (12) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2017-195

  • Genomics

    • Research Watch
      The MHC I Genotype Influences Early Driver Events in Cancer
      Cancer Discov December 1 2017 7 (12) 1366-1366; DOI:10.1158/2159-8290.CD-RW2017-206

  • Glioma

    • Research Watch
      H3.3K27M Expression Combined with Trp53 Loss Induces High-Grade Glioma
      Cancer Discov December 1 2017 7 (12) 1367-1367; DOI:10.1158/2159-8290.CD-RW2017-207

  • Immunology

    • Research Watch
      IL1R8 May Be a Natural Killer Cell Checkpoint Protein
      Cancer Discov December 1 2017 7 (12) 1367-1367; DOI:10.1158/2159-8290.CD-RW2017-208

  • Immunotherapy

    • Research Watch
      RNA-Based Genetic Circuits Are a Potential Antitumor Immunotherapy
      Cancer Discov December 1 2017 7 (12) 1365-1365; DOI:10.1158/2159-8290.CD-RW2017-201

    • Research Watch
      Nivolumab Induces Tumor Evolution in Patients with Melanoma
      Cancer Discov December 1 2017 7 (12) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2017-197

  • Leukemia

    • Research Watch
      BTSA1 Activates BAX to Promote Apoptosis in Acute Myeloid Leukemia
      Cancer Discov December 1 2017 7 (12) 1363-1363; DOI:10.1158/2159-8290.CD-RW2017-199

  • Lung Cancer

    • Research Watch
      Keap1 Loss Drives Kras-Mutant Lung Cancer and Glutaminolysis Dependency
      Cancer Discov December 1 2017 7 (12) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2017-192

  • Metabolism

    • Research Watch
      Glucose Indirectly Fuels the TCA Cycle in Tumors via Lactate
      Cancer Discov December 1 2017 7 (12) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2017-209

    • Research Watch
      Breast Cancer Cells Recycle Ammonia to Generate Amino Acids
      Cancer Discov December 1 2017 7 (12) 1364-1364; DOI:10.1158/2159-8290.CD-RW2017-200

    • Signaling
      Lactate Fuels the TCA Cycle in Non–Small Cell Lung Cancer
      Cancer Discov December 1 2017 7 (12) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2017-193

  • Neuroblastoma

    • Research Watch
      SEMA3C Depletion Promotes Neuroblastoma Metastatic Dissemination
      Cancer Discov December 1 2017 7 (12) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2017-198

  • Prostate Cancer

    • Research Watch
      Adrenergic Nerves May Promote Angiogenesis in Prostate Cancer
      Cancer Discov December 1 2017 7 (12) 1366-1366; DOI:10.1158/2159-8290.CD-RW2017-204

  • Signaling

    • Research Watch
      SLC38A9 Links mTORC1 Activity to Lysosomal Amino Acid Release
      Cancer Discov December 1 2017 7 (12) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2017-203

    • Research Watch
      EGFR Ligands Have Differential Effects on Dimer Stability and Signaling
      Cancer Discov December 1 2017 7 (12) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2017-194

  • Ubiquitination

    • Research Watch
      Identified Selective USP7 Inhibitors Compete with Ubiquitin Binding
      Cancer Discov December 1 2017 7 (12) 1365-1365; DOI:10.1158/2159-8290.CD-RW2017-205

  • Acknowledgment to Reviewers

    • Acknowledgment to Reviewers
      Acknowledgment to Reviewers
      Cancer Discov December 1 2017 7 (12) 1480-1481; DOI:10.1158/2159-8290.CD-7-12-Reviewers

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Cancer Discovery: 7 (12)
December 2017
Volume 7, Issue 12
  • Table of Contents
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