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Targeting ALK: Precision Medicine Takes on Drug Resistance

Jessica J. Lin, Gregory J. Riely and Alice T. Shaw
Jessica J. Lin
1Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
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Gregory J. Riely
2Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
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Alice T. Shaw
1Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
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  • For correspondence: ashaw1@mgh.harvard.edu
DOI: 10.1158/2159-8290.CD-16-1123 Published February 2017
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Article Information

Volume 7, Issue 2, pp. 137-155

DOI 
https://doi.org/10.1158/2159-8290.CD-16-1123
PubMed 
28122866

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received October 5, 2016
  • Revision received December 13, 2016
  • Accepted December 14, 2016
  • Published first January 25, 2017.

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  • Previous version (January 25, 2017 - 05:54).
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©2017 American Association for Cancer Research.

Author Information

  1. Jessica J. Lin1,
  2. Gregory J. Riely2 and
  3. Alice T. Shaw1,*
  1. 1Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  2. 2Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
  1. ↵*Corresponding Author:
    Alice T. Shaw, Massachusetts General Hospital Cancer Center, Department of Thoracic Oncology, 32 Fruit Street, Boston, MA 02114. Phone: 617-724-4000; Fax: 617-726-0453; E-mail: ashaw1{at}mgh.harvard.edu
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Cancer Discovery: 7 (2)
February 2017
Volume 7, Issue 2
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Targeting ALK: Precision Medicine Takes on Drug Resistance
Jessica J. Lin, Gregory J. Riely and Alice T. Shaw
Cancer Discov February 1 2017 (7) (2) 137-155; DOI: 10.1158/2159-8290.CD-16-1123

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Targeting ALK: Precision Medicine Takes on Drug Resistance
Jessica J. Lin, Gregory J. Riely and Alice T. Shaw
Cancer Discov February 1 2017 (7) (2) 137-155; DOI: 10.1158/2159-8290.CD-16-1123
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  • Article
    • Abstract
    • Introduction
    • ALK Biology
    • Targeting Oncogenic ALK
    • Mechanisms of Resistance to ALK TKIs
    • Tumor Heterogeneity and Resistance
    • Developing Strategies to Overcome Resistance
    • Conclusions
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
    • Acknowledgments
    • References
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