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Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists

Weiyi Toy, Hazel Weir, Pedram Razavi, Mandy Lawson, Anne U. Goeppert, Anne Marie Mazzola, Aaron Smith, Joanne Wilson, Christopher Morrow, Wai Lin Wong, Elisa De Stanchina, Kathryn E. Carlson, Teresa S. Martin, Sharmeen Uddin, Zhiqiang Li, Sean Fanning, John A. Katzenellenbogen, Geoffrey Greene, José Baselga and Sarat Chandarlapaty
Weiyi Toy
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Hazel Weir
2AstraZeneca, iMED Oncology, Cambridge, UK.
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Pedram Razavi
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
3Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Mandy Lawson
2AstraZeneca, iMED Oncology, Cambridge, UK.
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Anne U. Goeppert
4AstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge, UK.
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Anne Marie Mazzola
5AstraZeneca, iMED Oncology, Waltham, Massachusetts.
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Aaron Smith
2AstraZeneca, iMED Oncology, Cambridge, UK.
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Joanne Wilson
2AstraZeneca, iMED Oncology, Cambridge, UK.
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Christopher Morrow
2AstraZeneca, iMED Oncology, Cambridge, UK.
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Wai Lin Wong
6Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York.
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Elisa De Stanchina
6Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York.
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Kathryn E. Carlson
7Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois.
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Teresa S. Martin
7Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois.
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Sharmeen Uddin
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Zhiqiang Li
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Sean Fanning
8Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.
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John A. Katzenellenbogen
7Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois.
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Geoffrey Greene
8Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.
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José Baselga
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
3Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
9Weill Cornell Medical College, New York, New York.
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Sarat Chandarlapaty
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
3Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
9Weill Cornell Medical College, New York, New York.
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  • For correspondence: chandars@mskcc.org
DOI: 10.1158/2159-8290.CD-15-1523 Published March 2017
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ARTICLE USAGE: December 2016 to February 2021

AbstractFull-text HTMLPDF
Total808194468979

Cited By

Article Information

Volume 7, Issue 3, pp. 277-287

DOI 
https://doi.org/10.1158/2159-8290.CD-15-1523
PubMed 
27986707

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received December 23, 2015
  • Revision received December 8, 2016
  • Accepted December 14, 2016
  • Published first December 16, 2016.

Article Versions

  • Previous version (December 16, 2016 - 05:58).
  • Previous version (February 14, 2017 - 06:56).
  • Previous version (February 17, 2017 - 10:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Weiyi Toy1,
  2. Hazel Weir2,
  3. Pedram Razavi1,3,
  4. Mandy Lawson2,
  5. Anne U. Goeppert4,
  6. Anne Marie Mazzola5,
  7. Aaron Smith2,
  8. Joanne Wilson2,
  9. Christopher Morrow2,
  10. Wai Lin Wong6,
  11. Elisa De Stanchina6,
  12. Kathryn E. Carlson7,
  13. Teresa S. Martin7,
  14. Sharmeen Uddin1,
  15. Zhiqiang Li1,
  16. Sean Fanning8,
  17. John A. Katzenellenbogen7,
  18. Geoffrey Greene8,
  19. José Baselga1,3,9 and
  20. Sarat Chandarlapaty1,3,9,*
  1. 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  2. 2AstraZeneca, iMED Oncology, Cambridge, UK.
  3. 3Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  4. 4AstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge, UK.
  5. 5AstraZeneca, iMED Oncology, Waltham, Massachusetts.
  6. 6Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York.
  7. 7Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois.
  8. 8Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.
  9. 9Weill Cornell Medical College, New York, New York.
  1. ↵*Corresponding Author:
    Sarat Chandarlapaty, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065. Phone: 646-888-3387; Fax: 646-888-3406; E-mail: chandars{at}mskcc.org
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Cancer Discovery: 7 (3)
March 2017
Volume 7, Issue 3
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Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
Weiyi Toy, Hazel Weir, Pedram Razavi, Mandy Lawson, Anne U. Goeppert, Anne Marie Mazzola, Aaron Smith, Joanne Wilson, Christopher Morrow, Wai Lin Wong, Elisa De Stanchina, Kathryn E. Carlson, Teresa S. Martin, Sharmeen Uddin, Zhiqiang Li, Sean Fanning, John A. Katzenellenbogen, Geoffrey Greene, José Baselga and Sarat Chandarlapaty
Cancer Discov March 1 2017 (7) (3) 277-287; DOI: 10.1158/2159-8290.CD-15-1523

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Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
Weiyi Toy, Hazel Weir, Pedram Razavi, Mandy Lawson, Anne U. Goeppert, Anne Marie Mazzola, Aaron Smith, Joanne Wilson, Christopher Morrow, Wai Lin Wong, Elisa De Stanchina, Kathryn E. Carlson, Teresa S. Martin, Sharmeen Uddin, Zhiqiang Li, Sean Fanning, John A. Katzenellenbogen, Geoffrey Greene, José Baselga and Sarat Chandarlapaty
Cancer Discov March 1 2017 (7) (3) 277-287; DOI: 10.1158/2159-8290.CD-15-1523
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