Table of Contents

Research Articles

• Research Articles | AuthorChoice

  Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

  Chantal Pauli, Benjamin D. Hopkins, Davide Prandi, Reid Shaw, Tarcisio Fedrizzi, Andrea Sboner, Verena Sailer, Michael Augello, Loredana Puca, Rachele Rosati, Terra J. McNary, Yelena Churakova, Cynthia Cheung, Joanna Triscott, David Pisapia, Rema Rao, Juan Miguel Mosquera, Brian Robinson, Bishoy M. Faltas, Brooke E. Emerling, Vijayakrishna K. Gadi, Brady Bernard, Olivier Elemento, Himisha Beltran, Francesca Demichelis, Christopher J. Kemp, Carla Grandori, Lewis C. Cantley and Mark A. Rubin

  Cancer Discov May 1 2017 7 (5) 462-477; DOI:10.1158/2159-8290.CD-16-1154

  
  

  A precision medicine approach with high-throughput drug screening in patient-derived tumor organoids and PDX models may identify effective therapeutic strategies in patients without actionable mutations.

• Research Articles | AuthorChoice

  AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

  Katharine Yen, Jeremy Travins, Fang Wang, Muriel D. David, Erin Artin, Kimberly Straley, Anil Padyana, Stefan Gross, Byron DeLaBarre, Erica Tobin, Yue Chen, Raj Nagaraja, Sung Choe, Lei Jin, Zenon Konteatis, Giovanni Cianchetta, Jeffrey O. Saunders, Francesco G. Salituro, Cyril Quivoron, Paule Opolon, Olivia Bawa, Véronique Saada, Angelo Paci, Sophie Broutin, Olivier A. Bernard, Stéphane de Botton, Benoît S. Marteyn, Monika Pilichowska, YingXia Xu, Cheng Fang, Fan Jiang, Wentao Wei, Shengfang Jin, Lee Silverman, Wei Liu, Hua Yang, Lenny Dang, Marion Dorsch, Virginie Penard-Lacronique, Scott A. Biller and Shin-San Michael Su

  Cancer Discov May 1 2017 7 (5) 478-493; DOI:10.1158/2159-8290.CD-16-1034

  
  

  Targeted inhibition of IDH2^R140Q with the allosteric inhibitor AG-221 reduces production of the oncometabolite 2HG, promotes differentiation of malignant AML blasts, and extends survival in AML xenografts.

• Research Articles

  Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia

  Alan H. Shih, Cem Meydan, Kaitlyn Shank, Francine E. Garrett-Bakelman, Patrick S. Ward, Andrew M. Intlekofer, Abbas Nazir, Eytan M. Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Christopher E. Mason, Katharine Yen, Craig B. Thompson, Ari Melnick and Ross L. Levine

  Cancer Discov May 1 2017 7 (5) 494-505; DOI:10.1158/2159-8290.CD-16-1049

  
  

  Mutations in TET2 or IDH2 sensitize AML cells to the DNA hypomethylating agents 5-Aza and AG-221, which induce differentiation, reverse aberrant hypermethylation, and cooperate with FLT3 inhibition to suppress AML.

• Research Articles | AuthorChoice

  BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells

  Ester Valls, Camille Lobry, Huimin Geng, Ling Wang, Mariano Cardenas, Martín Rivas, Leandro Cerchietti, Philmo Oh, Shao Ning Yang, Erin Oswald, Camille W. Graham, Yanwen Jiang, Katerina Hatzi, Xabier Agirre, Eric Perkey, Zhuoning Li, Wayne Tam, Kamala Bhatt, John P. Leonard, Patrick A. Zweidler-McKay, Ivan Maillard, Olivier Elemento, Weimin Ci, Iannis Aifantis and Ari Melnick

  Cancer Discov May 1 2017 7 (5) 506-521; DOI:10.1158/2159-8290.CD-16-1189

  
  

  BCL6 binds to and represses NOTCH2 and other NOTCH pathway genes in follicular lymphoma and GC B cells to promote their survival, and BCL6 inhibition suppresses the growth of follicular lymphoma xenografts.

• Research Articles

  Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE₂-Mediated Suppression of Antitumor Immunity

  Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto, Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M. Taketo, Tomohiro Aoki, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara and Naoko Ohtani

  Cancer Discov May 1 2017 7 (5) 522-538; DOI:10.1158/2159-8290.CD-16-0932

  
  

  The obesity-associated gut microbial component and metabolite, LTA and DCA, promote COX2-mediated PGE₂ production in senescent HSCs to suppress the antitumor immunity in mice fed a high-fat diet and promote HCC.