Table of Contents
In This Issue
In the Spotlight
- In the Spotlight | Free ArticleGabriele Picco and Mathew J. GarnettCancer Discov May 1 2017 7 (5) 456-458; DOI:10.1158/2159-8290.CD-17-0268
- In the SpotlightDaniel Thomas and Ravindra MajetiCancer Discov May 1 2017 7 (5) 459-461; DOI:10.1158/2159-8290.CD-17-0270
Research Articles
- Research Articles | AuthorChoiceChantal Pauli, Benjamin D. Hopkins, Davide Prandi, Reid Shaw, Tarcisio Fedrizzi, Andrea Sboner, Verena Sailer, Michael Augello, Loredana Puca, Rachele Rosati, Terra J. McNary, Yelena Churakova, Cynthia Cheung, Joanna Triscott, David Pisapia, Rema Rao, Juan Miguel Mosquera, Brian Robinson, Bishoy M. Faltas, Brooke E. Emerling, Vijayakrishna K. Gadi, Brady Bernard, Olivier Elemento, Himisha Beltran, Francesca Demichelis, Christopher J. Kemp, Carla Grandori, Lewis C. Cantley and Mark A. RubinCancer Discov May 1 2017 7 (5) 462-477; DOI:10.1158/2159-8290.CD-16-1154
A precision medicine approach with high-throughput drug screening in patient-derived tumor organoids and PDX models may identify effective therapeutic strategies in patients without actionable mutations.
- Research Articles | AuthorChoiceAG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 MutationsKatharine Yen, Jeremy Travins, Fang Wang, Muriel D. David, Erin Artin, Kimberly Straley, Anil Padyana, Stefan Gross, Byron DeLaBarre, Erica Tobin, Yue Chen, Raj Nagaraja, Sung Choe, Lei Jin, Zenon Konteatis, Giovanni Cianchetta, Jeffrey O. Saunders, Francesco G. Salituro, Cyril Quivoron, Paule Opolon, Olivia Bawa, Véronique Saada, Angelo Paci, Sophie Broutin, Olivier A. Bernard, Stéphane de Botton, Benoît S. Marteyn, Monika Pilichowska, YingXia Xu, Cheng Fang, Fan Jiang, Wentao Wei, Shengfang Jin, Lee Silverman, Wei Liu, Hua Yang, Lenny Dang, Marion Dorsch, Virginie Penard-Lacronique, Scott A. Biller and Shin-San Michael SuCancer Discov May 1 2017 7 (5) 478-493; DOI:10.1158/2159-8290.CD-16-1034
Targeted inhibition of IDH2R140Q with the allosteric inhibitor AG-221 reduces production of the oncometabolite 2HG, promotes differentiation of malignant AML blasts, and extends survival in AML xenografts.
- Research ArticlesAlan H. Shih, Cem Meydan, Kaitlyn Shank, Francine E. Garrett-Bakelman, Patrick S. Ward, Andrew M. Intlekofer, Abbas Nazir, Eytan M. Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Christopher E. Mason, Katharine Yen, Craig B. Thompson, Ari Melnick and Ross L. LevineCancer Discov May 1 2017 7 (5) 494-505; DOI:10.1158/2159-8290.CD-16-1049
Mutations in TET2 or IDH2 sensitize AML cells to the DNA hypomethylating agents 5-Aza and AG-221, which induce differentiation, reverse aberrant hypermethylation, and cooperate with FLT3 inhibition to suppress AML.
- Research Articles | AuthorChoiceEster Valls, Camille Lobry, Huimin Geng, Ling Wang, Mariano Cardenas, Martín Rivas, Leandro Cerchietti, Philmo Oh, Shao Ning Yang, Erin Oswald, Camille W. Graham, Yanwen Jiang, Katerina Hatzi, Xabier Agirre, Eric Perkey, Zhuoning Li, Wayne Tam, Kamala Bhatt, John P. Leonard, Patrick A. Zweidler-McKay, Ivan Maillard, Olivier Elemento, Weimin Ci, Iannis Aifantis and Ari MelnickCancer Discov May 1 2017 7 (5) 506-521; DOI:10.1158/2159-8290.CD-16-1189
BCL6 binds to and represses NOTCH2 and other NOTCH pathway genes in follicular lymphoma and GC B cells to promote their survival, and BCL6 inhibition suppresses the growth of follicular lymphoma xenografts.
- Research ArticlesTze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto, Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M. Taketo, Tomohiro Aoki, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara and Naoko OhtaniCancer Discov May 1 2017 7 (5) 522-538; DOI:10.1158/2159-8290.CD-16-0932
The obesity-associated gut microbial component and metabolite, LTA and DCA, promote COX2-mediated PGE2 production in senescent HSCs to suppress the antitumor immunity in mice fed a high-fat diet and promote HCC.
News in Brief
- News in BriefCancer Discov May 1 2017 7 (5) 446-446; DOI:10.1158/2159-8290.CD-NB2017-046
- News in BriefCancer Discov May 1 2017 7 (5) 446-447; DOI:10.1158/2159-8290.CD-NB2017-037
- News in BriefCancer Discov May 1 2017 7 (5) 447-448; DOI:10.1158/2159-8290.CD-NB2017-038
- News in BriefCancer Discov May 1 2017 7 (5) 448-448; DOI:10.1158/2159-8290.CD-NB2017-039
- News in BriefCancer Discov May 1 2017 7 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2017-044
- News in BriefCancer Discov May 1 2017 7 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2017-045
- News in BriefCancer Discov May 1 2017 7 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2017-043
- News in BriefCancer Discov May 1 2017 7 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2017-042
- News in BriefCancer Discov May 1 2017 7 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2017-041
- News in BriefCancer Discov May 1 2017 7 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2017-040
- News in BriefCancer Discov May 1 2017 7 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2017-036
- News in BriefCancer Discov May 1 2017 7 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2017-035
News in Depth
- News in DepthCancer Discov May 1 2017 7 (5) 449-449; DOI:10.1158/2159-8290.CD-ND2017-001
Research Watch
Brain Tumors
- Research WatchCancer Discov May 1 2017 7 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2017-060
- Research WatchCancer Discov May 1 2017 7 (5) 453-453; DOI:10.1158/2159-8290.CD-RW2017-057
Breast Cancer
- Research WatchCancer Discov May 1 2017 7 (5) 455-455; DOI:10.1158/2159-8290.CD-RW2017-063
Clinical Trials
- Research WatchCancer Discov May 1 2017 7 (5) 451-451; DOI:10.1158/2159-8290.CD-RW2017-047
- Research WatchCancer Discov May 1 2017 7 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2017-048
- Research WatchCancer Discov May 1 2017 7 (5) 452-452; DOI:10.1158/2159-8290.CD-RW2017-052
DNA Damage
- Research WatchCancer Discov May 1 2017 7 (5) 455-455; DOI:10.1158/2159-8290.CD-RW2017-058
Epigenetics
- Research WatchCancer Discov May 1 2017 7 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2017-050
Immunology
- Research WatchCancer Discov May 1 2017 7 (5) 451-451; DOI:10.1158/2159-8290.CD-RW2017-053
Immunotherapy
- Research WatchCancer Discov May 1 2017 7 (5) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2017-064
- Research WatchCancer Discov May 1 2017 7 (5) 453-453; DOI:10.1158/2159-8290.CD-RW2017-055
Kinase Inhibitors
- Research WatchCancer Discov May 1 2017 7 (5) 454-454; DOI:10.1158/2159-8290.CD-RW2017-062
Leukemia
- Research WatchCancer Discov May 1 2017 7 (5) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2017-059
- Research WatchCancer Discov May 1 2017 7 (5) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2017-049
Metastasis
- Research WatchCancer Discov May 1 2017 7 (5) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2017-051
Multiple Myeloma
- Research WatchCancer Discov May 1 2017 7 (5) 452-452; DOI:10.1158/2159-8290.CD-RW2017-054
Prostate Cancer
- Research WatchCancer Discov May 1 2017 7 (5) 454-454; DOI:10.1158/2159-8290.CD-RW2017-061
Splicing
- Research WatchCancer Discov May 1 2017 7 (5) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2017-056
Structural Biology
- Research WatchCancer Discov May 1 2017 7 (5) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2017-046
Volume 7, Issue 5
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