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Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk and Lewis C. Cantley
Akash Patnaik
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
3Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
4The University of Chicago Comprehensive Cancer Center, Chicago, Illinois.
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  • For correspondence: apatnaik1@uchicago.edu
Kenneth D. Swanson
5Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Eva Csizmadia
6Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
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Aniruddh Solanki
7Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
8Harvard Stem Cell Institute, Boston, Massachusetts.
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Natalie Landon-Brace
7Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
8Harvard Stem Cell Institute, Boston, Massachusetts.
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Marina P. Gehring
5Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
9Laboratório de Farmacologia Aplicada, PUCRS, Porto Alegre, Brazil.
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Katja Helenius
10Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Brian M. Olson
3Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
4The University of Chicago Comprehensive Cancer Center, Chicago, Illinois.
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Athalia R. Pyzer
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
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Lily C. Wang
11Meyer Cancer Center, Weill Cornell Medical College, New York, New York.
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Olivier Elemento
11Meyer Cancer Center, Weill Cornell Medical College, New York, New York.
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Jesse Novak
12Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Thomas B. Thornley
13Transplant Institute and Immunology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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John M. Asara
14Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Laleh Montaser
15Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Joshua J. Timmons
5Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Todd M. Morgan
16Department of Urology, University of Michigan, Ann Arbor, Michigan.
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Yugang Wang
16Department of Urology, University of Michigan, Ann Arbor, Michigan.
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Elena Levantini
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
8Harvard Stem Cell Institute, Boston, Massachusetts.
17Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy.
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John G. Clohessy
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
18Preclinical Murine Pharmacogenetics Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Kathleen Kelly
19Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, Maryland.
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Pier Paolo Pandolfi
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Jacalyn M. Rosenblatt
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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David E. Avigan
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Huihui Ye
15Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Jeffrey M. Karp
7Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
8Harvard Stem Cell Institute, Boston, Massachusetts.
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Sabina Signoretti
12Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Steven P. Balk
1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Lewis C. Cantley
11Meyer Cancer Center, Weill Cornell Medical College, New York, New York.
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DOI: 10.1158/2159-8290.CD-16-0778 Published July 2017
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Article Information

Volume 7, Issue 7, pp. 750-765

DOI 
https://doi.org/10.1158/2159-8290.CD-16-0778
PubMed 
28274958

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received July 15, 2016
  • Revision received October 7, 2016
  • Accepted March 6, 2017
  • Published first March 8, 2017.

Article Versions

  • Previous version (March 8, 2017 - 12:30).
  • Previous version (June 12, 2017 - 06:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Akash Patnaik1,2,3,4,*,
  2. Kenneth D. Swanson5,
  3. Eva Csizmadia6,
  4. Aniruddh Solanki7,8,
  5. Natalie Landon-Brace7,8,
  6. Marina P. Gehring5,9,
  7. Katja Helenius10,
  8. Brian M. Olson3,4,
  9. Athalia R. Pyzer1,
  10. Lily C. Wang11,
  11. Olivier Elemento11,
  12. Jesse Novak12,
  13. Thomas B. Thornley13,
  14. John M. Asara14,
  15. Laleh Montaser15,
  16. Joshua J. Timmons5,
  17. Todd M. Morgan16,
  18. Yugang Wang16,
  19. Elena Levantini1,8,17,
  20. John G. Clohessy2,18,
  21. Kathleen Kelly19,
  22. Pier Paolo Pandolfi2,
  23. Jacalyn M. Rosenblatt1,2,
  24. David E. Avigan1,2,
  25. Huihui Ye15,
  26. Jeffrey M. Karp7,8,
  27. Sabina Signoretti12,
  28. Steven P. Balk1,2 and
  29. Lewis C. Cantley11
  1. 1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts.
  2. 2Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  3. 3Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
  4. 4The University of Chicago Comprehensive Cancer Center, Chicago, Illinois.
  5. 5Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  6. 6Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
  7. 7Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  8. 8Harvard Stem Cell Institute, Boston, Massachusetts.
  9. 9Laboratório de Farmacologia Aplicada, PUCRS, Porto Alegre, Brazil.
  10. 10Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  11. 11Meyer Cancer Center, Weill Cornell Medical College, New York, New York.
  12. 12Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  13. 13Transplant Institute and Immunology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  14. 14Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  15. 15Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  16. 16Department of Urology, University of Michigan, Ann Arbor, Michigan.
  17. 17Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy.
  18. 18Preclinical Murine Pharmacogenetics Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  19. 19Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, Maryland.
  1. ↵*Corresponding Author:
    Akash Patnaik, The University of Chicago, Knapp Center for Biomedical Discovery, Room 7152, 900 East 57th Street, Chicago, IL 60637. Phone: 773-834-3519; Fax: 773-834-0778; E-mail: apatnaik1{at}uchicago.edu
  1. M.P. Gehring, K. Helenius, B.M. Olson, and A.R. Pyzer contributed equally to this article.

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Cancer Discovery: 7 (7)
July 2017
Volume 7, Issue 7
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Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk and Lewis C. Cantley
Cancer Discov July 1 2017 (7) (7) 750-765; DOI: 10.1158/2159-8290.CD-16-0778

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Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk and Lewis C. Cantley
Cancer Discov July 1 2017 (7) (7) 750-765; DOI: 10.1158/2159-8290.CD-16-0778
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