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Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V. Tinker, Nelson N.H. Teng, Maria I. Harrell, Michael J. Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M. Kass, Meghan R. Sullivan, Gregory J. Brunette, Kara A. Bernstein, Robert L. Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M. O'Malley, Amit Oza, James Sun, Liliane Robillard, Lara Maloney, David Bowtell; on behalf of the AOCS Study Group, Heidi Giordano, Matthew J. Wakefield, Scott H. Kaufmann, Andrew D. Simmons, Thomas C. Harding, Mitch Raponi, Iain A. McNeish, Elizabeth M. Swisher, Kevin K. Lin and Clare L. Scott
Olga Kondrashova
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
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Minh Nguyen
Clovis Oncology, Inc., Boulder, Colorado.
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Kristy Shield-Artin
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
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Anna V. Tinker
British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
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Nelson N.H. Teng
Stanford University, Palo Alto, California.
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Maria I. Harrell
University of Washington, Seattle, Washington.
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Michael J. Kuiper
Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia.
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Gwo-Yaw Ho
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Holly Barker
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
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Maria Jasin
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Rohit Prakash
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Elizabeth M. Kass
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Meghan R. Sullivan
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Gregory J. Brunette
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Kara A. Bernstein
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Robert L. Coleman
The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Anne Floquet
Institut Bergonié, Bordeaux, France.
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Michael Friedlander
University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia.
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Ganessan Kichenadasse
Flinders University, Adelaide, South Australia, Australia.
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David M. O'Malley
The Ohio State University, James Cancer Center, Columbus, Ohio.
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Amit Oza
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
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James Sun
Foundation Medicine, Inc., Cambridge, Massachusetts.
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Liliane Robillard
Clovis Oncology, Inc., Boulder, Colorado.
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Lara Maloney
Clovis Oncology, Inc., Boulder, Colorado.
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David Bowtell
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.Centre for Cancer Research, University of Sydney at Westmead Millennium Institute, and Departments of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Heidi Giordano
Clovis Oncology, Inc., Boulder, Colorado.
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Matthew J. Wakefield
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia.
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Scott H. Kaufmann
Mayo Clinic Cancer Center, Rochester, Minnesota.
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Andrew D. Simmons
Clovis Oncology, Inc., Boulder, Colorado.
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Thomas C. Harding
Clovis Oncology, Inc., Boulder, Colorado.
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Mitch Raponi
Clovis Oncology, Inc., Boulder, Colorado.
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Iain A. McNeish
Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
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Elizabeth M. Swisher
University of Washington, Seattle, Washington.
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Kevin K. Lin
Clovis Oncology, Inc., Boulder, Colorado.
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Clare L. Scott
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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  • For correspondence: scottc@wehi.edu.au
DOI: 10.1158/2159-8290.CD-17-0419 Published September 2017
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Cited By

Article Information

Volume 7, Issue 9, pp. 984-998

DOI 
https://doi.org/10.1158/2159-8290.CD-17-0419
PubMed 
28588062

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received April 21, 2017
  • Revision received June 1, 2017
  • Accepted June 2, 2017
  • Published first June 6, 2017.

Article Versions

  • Previous version (June 6, 2017 - 06:02).
  • Previous version (August 14, 2017 - 06:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Olga Kondrashova1,2,
  2. Minh Nguyen3,
  3. Kristy Shield-Artin1,2,
  4. Anna V. Tinker4,
  5. Nelson N.H. Teng5,
  6. Maria I. Harrell6,
  7. Michael J. Kuiper7,
  8. Gwo-Yaw Ho1,2,8,
  9. Holly Barker1,2,
  10. Maria Jasin9,
  11. Rohit Prakash9,
  12. Elizabeth M. Kass9,
  13. Meghan R. Sullivan10,
  14. Gregory J. Brunette10,
  15. Kara A. Bernstein10,
  16. Robert L. Coleman11,
  17. Anne Floquet12,
  18. Michael Friedlander13,
  19. Ganessan Kichenadasse14,
  20. David M. O'Malley15,
  21. Amit Oza16,
  22. James Sun17,
  23. Liliane Robillard3,
  24. Lara Maloney3,
  25. David Bowtell on behalf of the AOCS Study Group18,19,20,
  26. Heidi Giordano3,
  27. Matthew J. Wakefield1,7,
  28. Scott H. Kaufmann21,
  29. Andrew D. Simmons3,
  30. Thomas C. Harding3,
  31. Mitch Raponi3,
  32. Iain A. McNeish22,
  33. Elizabeth M. Swisher6,
  34. Kevin K. Lin3 and
  35. Clare L. Scott1,2,8,*
  1. 1Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
  2. 2Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
  3. 3Clovis Oncology, Inc., Boulder, Colorado.
  4. 4British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
  5. 5Stanford University, Palo Alto, California.
  6. 6University of Washington, Seattle, Washington.
  7. 7Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia.
  8. 8Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  9. 9Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  10. 10Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  11. 11The University of Texas MD Anderson Cancer Center, Houston, Texas.
  12. 12Institut Bergonié, Bordeaux, France.
  13. 13University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia.
  14. 14Flinders University, Adelaide, South Australia, Australia.
  15. 15The Ohio State University, James Cancer Center, Columbus, Ohio.
  16. 16Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  17. 17Foundation Medicine, Inc., Cambridge, Massachusetts.
  18. 18Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  19. 19Centre for Cancer Research, University of Sydney at Westmead Millennium Institute, and Departments of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
  20. 20QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  21. 21Mayo Clinic Cancer Center, Rochester, Minnesota.
  22. 22Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
  1. ↵*Corresponding Author:
    Clare L. Scott, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61-3-9345-2498; Fax: 61-3-9347-0852; E-mail: scottc{at}wehi.edu.au
  1. O. Kondrashova, M. Nguyen, K. Shield-Artin, K.K. Lin, and Clare L. Scott contributed equally to this article.

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Cancer Discovery: 7 (9)
September 2017
Volume 7, Issue 9
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Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V. Tinker, Nelson N.H. Teng, Maria I. Harrell, Michael J. Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M. Kass, Meghan R. Sullivan, Gregory J. Brunette, Kara A. Bernstein, Robert L. Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M. O'Malley, Amit Oza, James Sun, Liliane Robillard, Lara Maloney, David Bowtell, Heidi Giordano, Matthew J. Wakefield, Scott H. Kaufmann, Andrew D. Simmons, Thomas C. Harding, Mitch Raponi, Iain A. McNeish, Elizabeth M. Swisher, Kevin K. Lin and Clare L. Scott on behalf of the AOCS Study Group
Cancer Discov September 1 2017 (7) (9) 984-998; DOI: 10.1158/2159-8290.CD-17-0419

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Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V. Tinker, Nelson N.H. Teng, Maria I. Harrell, Michael J. Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M. Kass, Meghan R. Sullivan, Gregory J. Brunette, Kara A. Bernstein, Robert L. Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M. O'Malley, Amit Oza, James Sun, Liliane Robillard, Lara Maloney, David Bowtell, Heidi Giordano, Matthew J. Wakefield, Scott H. Kaufmann, Andrew D. Simmons, Thomas C. Harding, Mitch Raponi, Iain A. McNeish, Elizabeth M. Swisher, Kevin K. Lin and Clare L. Scott on behalf of the AOCS Study Group
Cancer Discov September 1 2017 (7) (9) 984-998; DOI: 10.1158/2159-8290.CD-17-0419
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