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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov January 1 2018 8 (1) 1-3; DOI:10.1158/2159-8290.CD-ITI8-1

In the Spotlight

  • In the Spotlight
    Genomic Analyses and Precision Oncology in Gastroesophageal Cancer: Forwards or Backwards?
    Raghav Sundar and Patrick Tan
    Cancer Discov January 1 2018 8 (1) 14-16; DOI:10.1158/2159-8290.CD-17-1295

  • In the Spotlight
    Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription
    Alessandro Carugo and Giulio F. Draetta
    Cancer Discov January 1 2018 8 (1) 17-19; DOI:10.1158/2159-8290.CD-17-1245

  • In the Spotlight
    Keeping Tumors Out of the MAPK Fitness Zone
    David F. Stern
    Cancer Discov January 1 2018 8 (1) 20-23; DOI:10.1158/2159-8290.CD-17-1243

Review

  • Review
    BET Proteins as Targets for Anticancer Treatment
    Anastasios Stathis and Francesco Bertoni
    Cancer Discov January 1 2018 8 (1) 24-36; DOI:10.1158/2159-8290.CD-17-0605

Research Briefs

  • Research Briefs | AuthorChoice
    Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma
    Eirini Pectasides, Matthew D. Stachler, Sarah Derks, Yang Liu, Steven Maron, Mirazul Islam, Lindsay Alpert, Heewon Kwak, Hedy Kindler, Blase Polite, Manish R. Sharma, Kenisha Allen, Emily O'Day, Samantha Lomnicki, Melissa Maranto, Rajani Kanteti, Carrie Fitzpatrick, Christopher Weber, Namrata Setia, Shu-Yuan Xiao, John Hart, Rebecca J. Nagy, Kyoung-Mee Kim, Min-Gew Choi, Byung-Hoon Min, Katie S. Nason, Lea O'Keefe, Masayuki Watanabe, Hideo Baba, Rick Lanman, Agoston T. Agoston, David J. Oh, Andrew Dunford, Aaron R. Thorner, Matthew D. Ducar, Bruce M. Wollison, Haley A. Coleman, Yuan Ji, Mitchell C. Posner, Kevin Roggin, Kiran Turaga, Paul Chang, Kyle Hogarth, Uzma Siddiqui, Andres Gelrud, Gavin Ha, Samuel S. Freeman, Justin Rhoades, Sarah Reed, Greg Gydush, Denisse Rotem, Jon Davison, Yu Imamura, Viktor Adalsteinsson, Jeeyun Lee, Adam J. Bass and Daniel V. Catenacci
    Cancer Discov January 1 2018 8 (1) 37-48; DOI:10.1158/2159-8290.CD-17-0395

    Heterogeneity of actionable genomic alterations among primary and metastatic lesions suggests that biomarker profiling of a single primary tumor site may limit the success of targeted therapy in gastroesophageal adenocarcinoma.

  • Research Briefs | AuthorChoice
    Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
    Yelena Y. Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K. Chatila, Jaclyn F. Hechtman, Geoffrey Y. Ku, Jamie C. Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary J. Heins, Benjamin E. Gross, David P. Kelsen, Liying Zhang, Vivian E. Strong, Mark Schattner, Hans Gerdes, Daniel G. Coit, Manjit Bains, Zsofia K. Stadler, Valerie W. Rusch, David R. Jones, Daniela Molena, Jinru Shia, Mark E. Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M. Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H. Ilson, Michael F. Berger, Laura Tang, Barry S. Taylor, David B. Solit and Nikolaus Schultz
    Cancer Discov January 1 2018 8 (1) 49-58; DOI:10.1158/2159-8290.CD-17-0787

    Prospective genomic profiling of patients with esophagogastric cancer identifies predictive biomarkers of sensitivity and resistance to trastuzumab and immune checkpoint inhibitors.

  • Research Briefs
    Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
    Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong and Peter S. Hammerman
    Cancer Discov January 1 2018 8 (1) 59-73; DOI:10.1158/2159-8290.CD-17-0461

    Blocking RNA polymerase II–mediated transcription with a CDK7/CDK12 inhibitor broadly enhances the efficacy of targeted therapies by suppressing transcriptional responses associated with establishment of a drug-tolerant state.

Research Articles

  • Research Articles | AuthorChoice
    Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
    Aayoung Hong, Gatien Moriceau, Lu Sun, Shirley Lomeli, Marco Piva, Robert Damoiseaux, Sheri L. Holmen, Norman E. Sharpless, Willy Hugo and Roger S. Lo
    Cancer Discov January 1 2018 8 (1) 74-93; DOI:10.1158/2159-8290.CD-17-0682

    Treatment discontinuation sensitizes MAPK inhibitor–resistant melanoma to PARP inhibition and augments a cell death–predominant drug-addiction phenotype.

  • Research Articles
    Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
    Xu Qian, Xinjian Li, Lin Tan, Jong-Ho Lee, Yan Xia, Qingsong Cai, Yanhua Zheng, Hongxia Wang, Philip L. Lorenzi and Zhimin Lu
    Cancer Discov January 1 2018 8 (1) 94-107; DOI:10.1158/2159-8290.CD-17-0712

    Inhibition of phosphoribosyl pyrophosphate synthetase (PRPS) by AMPK under glucose-deprived or hypoxic conditions maintains homeostasis and promotes tumor cell survival.

  • Research Articles | AuthorChoice
    Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor
    Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao, Joshua D. Campbell, Aruna Ramachandran, Yoichiro Mitsuishi, Gavin Ha, Juliann Shih, Francisca Vazquez, Aviad Tsherniak, Alison M. Taylor, Jin Zhou, Zhong Wu, Ashton C. Berger, Marios Giannakis, William C. Hahn, Andrew D. Cherniack and Matthew Meyerson
    Cancer Discov January 1 2018 8 (1) 108-125; DOI:10.1158/2159-8290.CD-17-0532

    Varied noncoding and coding alterations observed across multiple cancer types converge to increase KLF5 activity and create a potential therapeutic vulnerability.

News in Brief

  • News in Brief
    People
    Cancer Discov January 1 2018 8 (1) 4-4; DOI:10.1158/2159-8290.CD-NB2017-161

  • News in Brief
    Basket Study Yields Approval for Rare Cancer
    Cancer Discov January 1 2018 8 (1) 4-4; DOI:10.1158/2159-8290.CD-NB2017-163

  • News in Brief
    JCAR015 in ALL: A Root-Cause Investigation
    Cancer Discov January 1 2018 8 (1) 4-5; DOI:10.1158/2159-8290.CD-NB2017-169

  • News in Brief
    FDA Approves Second CAR T-cell Therapy
    Cancer Discov January 1 2018 8 (1) 5-6; DOI:10.1158/2159-8290.CD-NB2017-155

  • News in Brief
    Neoantigen Quality Predicts Immune Response, Survival
    Cancer Discov January 1 2018 8 (1) 6-6; DOI:10.1158/2159-8290.CD-NB2017-165

  • News in Brief
    Wild Microbiome Stems Tumorigenesis in Lab Mice
    Cancer Discov January 1 2018 8 (1) 6-7; DOI:10.1158/2159-8290.CD-NB2017-162

  • News in Brief
    Mainstreaming Cryo-EM in Cancer Research
    Cancer Discov January 1 2018 8 (1) 7-7; DOI:10.1158/2159-8290.CD-NB2017-159

  • News in Brief
    HLA Loss Facilitates Immune Escape
    Cancer Discov January 1 2018 8 (1) 8-8; DOI:10.1158/2159-8290.CD-NB2017-166

  • News in Brief
    Noted
    Cancer Discov January 1 2018 8 (1) 8-8; DOI:10.1158/2159-8290.CD-NB2017-160

  • News in Brief
    First-Line Osimertinib Beneficial in Advanced NSCLC
    Cancer Discov January 1 2018 8 (1) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2017-170

  • News in Brief
    Dasatinib Approved for Pediatric CML
    Cancer Discov January 1 2018 8 (1) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2017-168

  • News in Brief
    Blocking IDO1 Helps Shrink Bladder, Cervical Tumors
    Cancer Discov January 1 2018 8 (1) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2017-167

  • News in Brief
    Poziotinib Shows Promise for Rare Lung Cancer
    Cancer Discov January 1 2018 8 (1) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2017-164

  • News in Brief
    Rare Tumors in Kids May Respond to Tazemetostat
    Cancer Discov January 1 2018 8 (1) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2017-152

  • News in Brief
    Acalabrutinib Approved for MCL
    Cancer Discov January 1 2018 8 (1) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2017-158

  • News in Brief
    NIH Initiative Aims to Improve Immunotherapy
    Cancer Discov January 1 2018 8 (1) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2017-156

  • News in Brief
    Treating Recurrent Glioma with Toca 511
    Cancer Discov January 1 2018 8 (1) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2017-157

Research Watch

  • Clinical Trials

    • Research Watch
      Dabrafenib plus Trametinib Is Active in BRAFV600E Anaplastic Thyroid Cancer
      Cancer Discov January 1 2018 8 (1) 9-9; DOI:10.1158/2159-8290.CD-RW2017-212

  • DNA Repair

    • Research Watch
      Loss of DNA Repair Drives Neoantigen Renewal and Inhibits Tumor Growth
      Cancer Discov January 1 2018 8 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2017-228

  • Drug Resistance

    • Research Watch
      GPX4 Inhibition Selectively Targets Drug-Tolerant Persister Cells
      Cancer Discov January 1 2018 8 (1) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2017-215

  • Epigenetics

    • Research Watch
      Mutant IDH1R132H Induces Transcriptional and Epigenomic Reprogramming
      Cancer Discov January 1 2018 8 (1) 10-10; DOI:10.1158/2159-8290.CD-RW2017-229

  • Hepatocellular Carcinoma

    • Research Watch
      ARID1A Has Context-Specific Roles in Hepatocellular Carcinoma
      Cancer Discov January 1 2018 8 (1) 10-10; DOI:10.1158/2159-8290.CD-RW2017-221

    • Research Watch
      Inflammation-Induced IgA+ Cells Promote Hepatocellular Tumorigenesis
      Cancer Discov January 1 2018 8 (1) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2017-217

  • Immunology

    • Research Watch
      MYC Induces Immune Suppression to Promote Lung Tumorigenesis
      Cancer Discov January 1 2018 8 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2017-232

    • Research Watch
      PMN-MDSC Infiltration Blocks the Antitumor Effects of CSF1R Inhibition
      Cancer Discov January 1 2018 8 (1) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2017-224

  • Immunotherapy

    • Research Watch
      CDK4/6 Inhibitors Increase PD-L1 Expression
      Cancer Discov January 1 2018 8 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2017-225

  • Leukemia

    • Research Watch
      High BCAT1 Expression Mimics IDH Mutations in Acute Myeloid Leukemia
      Cancer Discov January 1 2018 8 (1) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2017-216

  • Lung Cancer

    • Research Watch
      Osteoblasts Promote Release of Tumor-Promoting SiglecFhi Neutrophils
      Cancer Discov January 1 2018 8 (1) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2017-230

    • Research Watch
      NFS1 Expression Protects Lung Tumor Cells from Ferroptosis
      Cancer Discov January 1 2018 8 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2017-231

    • Research Watch
      Co-occurring Alterations Affect Outcomes in EGFR-Mutant Lung Cancer
      Cancer Discov January 1 2018 8 (1) 9-9; DOI:10.1158/2159-8290.CD-RW2017-219

  • Lymphoma

    • Research Watch
      The T-cell Receptor β-Chain Is an Immunotherapy Target for Lymphomas
      Cancer Discov January 1 2018 8 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2017-220

    • Research Watch
      PD-1 Functions as a Tumor Suppressor in T-cell Lymphoma
      Cancer Discov January 1 2018 8 (1) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2017-222

  • Mitosis

    • Research Watch
      ATR Promotes Faithful Chromosome Segregation in Mitosis
      Cancer Discov January 1 2018 8 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2017-227

  • Multiple Myeloma

    • Research Watch
      The Active Conformation of Integrin β7 May Be a Multiple Myeloma Target
      Cancer Discov January 1 2018 8 (1) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2017-218

  • Pancreatic Cancer

    • Research Watch
      Pancreatitis-Induced p62 Accumulation Promotes Pancreatic Cancer
      Cancer Discov January 1 2018 8 (1) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2017-223

  • Pediatric Cancers

    • Signaling
      The DNA Transposase PGBD5 Sensitizes Tumors to Inhibition of DNA Repair
      Cancer Discov January 1 2018 8 (1) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2017-213

  • Signaling

    • Research Watch
      SRPK2 Acts Downstream of MTORC1 to Promote De Novo Lipogenesis
      Cancer Discov January 1 2018 8 (1) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2017-226

    • Research Watch
      NTZ Increases β-catenin Citrullination to Suppress WNT Signaling
      Cancer Discov January 1 2018 8 (1) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2017-214

  • Targeted Therapy

    • Research Watch
      BLU-285 Targets KIT/PDGFRA Conformation and Activating Loop Mutations
      Cancer Discov January 1 2018 8 (1) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2017-211

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Cancer Discovery: 8 (1)
January 2018
Volume 8, Issue 1
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