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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona
Haley E. Ramsey
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Melissa A. Fischer
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
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  • ORCID record for Melissa A. Fischer
Taekyu Lee
2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
3Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, Tennessee.
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Agnieszka E. Gorska
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Maria Pia Arrate
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Londa Fuller
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Kelli L. Boyd
4Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Stephen A. Strickland
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
5Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
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John Sensintaffar
2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Leah J. Hogdal
2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Gregory D. Ayers
5Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
7Vanderbilt Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.
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Edward T. Olejniczak
2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
3Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, Tennessee.
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Stephen W. Fesik
2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
3Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, Tennessee.
5Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
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Michael R. Savona
1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
5Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
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  • ORCID record for Michael R. Savona
  • For correspondence: michael.savona@vanderbilt.edu
DOI: 10.1158/2159-8290.CD-18-0140 Published December 2018
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Article Information

Volume 8, Issue 12, pp. 1566-1581

DOI 
https://doi.org/10.1158/2159-8290.CD-18-0140
PubMed 
30185627

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received February 14, 2018
  • Revision received July 14, 2018
  • Accepted August 28, 2018
  • Published first September 5, 2018.

Article Versions

  • Previous version (September 5, 2018 - 06:51).
  • Previous version (November 15, 2018 - 06:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Haley E. Ramsey1,
  2. Melissa A. Fischer1,
  3. Taekyu Lee2,3,
  4. Agnieszka E. Gorska1,
  5. Maria Pia Arrate1,
  6. Londa Fuller1,
  7. Kelli L. Boyd4,
  8. Stephen A. Strickland1,5,
  9. John Sensintaffar2,
  10. Leah J. Hogdal2,
  11. Gregory D. Ayers5,6,7,
  12. Edward T. Olejniczak2,3,
  13. Stephen W. Fesik2,3,5 and
  14. Michael R. Savona1,5,*
  1. 1Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
  2. 2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
  3. 3Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, Tennessee.
  4. 4Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
  5. 5Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  6. 6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
  7. 7Vanderbilt Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.
  1. ↵*Corresponding Author:
    Michael R. Savona, Vanderbilt University School of Medicine, 777 Preston Research Building, 2200 Pierce Avenue, Nashville, TN 37232. Phone: 615-936-3321; Fax: 615-343-7602; E-mail: michael.savona{at}vanderbilt.edu
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Cancer Discovery: 8 (12)
December 2018
Volume 8, Issue 12
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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona
Cancer Discov December 1 2018 (8) (12) 1566-1581; DOI: 10.1158/2159-8290.CD-18-0140

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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller, Kelli L. Boyd, Stephen A. Strickland, John Sensintaffar, Leah J. Hogdal, Gregory D. Ayers, Edward T. Olejniczak, Stephen W. Fesik and Michael R. Savona
Cancer Discov December 1 2018 (8) (12) 1566-1581; DOI: 10.1158/2159-8290.CD-18-0140
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