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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov July 1 2018 8 (7) 781-783; DOI:10.1158/2159-8290.CD-ITI8-7

In the Spotlight

  • In the Spotlight
    Epistatic Oncogenic Interactions Determine Cancer Susceptibility to Immunotherapy
    Iñaki Etxeberria, Alvaro Teijeira, Luis M. Montuenga, Pedro Berraondo and Ignacio Melero
    Cancer Discov July 1 2018 8 (7) 794-796; DOI:10.1158/2159-8290.CD-18-0573

  • In the Spotlight
    Stop fRETting the Target: Next-Generation RET Inhibitors Have Arrived
    Wade T. Iams and Christine M. Lovly
    Cancer Discov July 1 2018 8 (7) 797-799; DOI:10.1158/2159-8290.CD-18-0489

  • In the Spotlight
    Macropinocytosis Fuels Prostate Cancer
    Cosimo Commisso and Jayanta Debnath
    Cancer Discov July 1 2018 8 (7) 800-802; DOI:10.1158/2159-8290.CD-18-0513

Prospective

  • Prospective | AuthorChoice
    Precision Prevention and Early Detection of Cancer: Fundamental Principles
    Timothy R. Rebbeck, Karen Burns-White, Andrew T. Chan, Karen Emmons, Matthew Freedman, David J. Hunter, Peter Kraft, Francine Laden, Lorelei Mucci, Giovanni Parmigiani, Deborah Schrag, Sapna Syngal, Rulla M. Tamimi, Kasisomayajula Viswanath, Matthew B. Yurgelun and Judy E. Garber
    Cancer Discov July 1 2018 8 (7) 803-811; DOI:10.1158/2159-8290.CD-17-1415

Research Articles

  • Research Articles | AuthorChoice
    Efficacy of BGJ398, a Fibroblast Growth Factor Receptor 1–3 Inhibitor, in Patients with Previously Treated Advanced Urothelial Carcinoma with FGFR3 Alterations
    Sumanta K. Pal, Jonathan E. Rosenberg, Jean H. Hoffman-Censits, Raanan Berger, David I. Quinn, Matthew D. Galsky, Juergen Wolf, Christian Dittrich, Bhumsuk Keam, Jean-Pierre Delord, Jan H.M. Schellens, Gwenaelle Gravis, Jacques Medioni, Pablo Maroto, Virote Sriuranpong, Chaiyut Charoentum, Howard A. Burris, Viktor Grünwald, Daniel Petrylak, Ulka Vaishampayan, Eliahu Gez, Ugo De Giorgi, Jae-Lyun Lee, Jens Voortman, Sumati Gupta, Sunil Sharma, Amir Mortazavi, David J. Vaughn, Randi Isaacs, Katie Parker, Xueying Chen, Kun Yu, Dale Porter, Diana Graus Porta and Dean F. Bajorin
    Cancer Discov July 1 2018 8 (7) 812-821; DOI:10.1158/2159-8290.CD-18-0229

    The FGFR1–3 inhibitor BGJ398 achieved responses with an acceptable safety profile in an expansion cohort of 67 patients with metastatic FGFR3-altered urothelial carcinoma.

  • Research Articles | AuthorChoice
    STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma
    Ferdinandos Skoulidis, Michael E. Goldberg, Danielle M. Greenawalt, Matthew D. Hellmann, Mark M. Awad, Justin F. Gainor, Alexa B. Schrock, Ryan J. Hartmaier, Sally E. Trabucco, Laurie Gay, Siraj M. Ali, Julia A. Elvin, Gaurav Singal, Jeffrey S. Ross, David Fabrizio, Peter M. Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A. Bufill, Neelesh Sharma, Sai-Hong I. Ou, Nir Peled, David R. Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W. Carter, Jeremy Erasmus, Darragh F. Halpenny, Andrew J. Plodkowski, Niamh M. Long, Mizuki Nishino, Warren L. Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A. Villalobos, Edwin R. Parra, Neda Kalhor, Lynette M. Sholl, Jennifer L. Sauter, Achim A. Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y. Elamin, Jianjun Zhang, Giulia C. Leonardi, Fei Jiang, Kwok-Kin Wong, J. Jack Lee, Vassiliki A. Papadimitrakopoulou, Ignacio I. Wistuba, Vincent A. Miller, Garrett M. Frampton, Jedd D. Wolchok, Alice T. Shaw, Pasi A. Jänne, Philip J. Stephens, Charles M. Rudin, William J. Geese, Lee A. Albacker and John V. Heymach
    Cancer Discov July 1 2018 8 (7) 822-835; DOI:10.1158/2159-8290.CD-18-0099

    In patients with KRAS-mutant lung adenocarcinoma, co-occurring alterations in STK11 conferred primary resistance to PD-1 blockade, suggesting that genomic profiling may guide selection of patients likely to respond.

  • Research Articles | AuthorChoice
    Precision Targeted Therapy with BLU-667 for RET-Driven Cancers
    Vivek Subbiah, Justin F. Gainor, Rami Rahal, Jason D. Brubaker, Joseph L. Kim, Michelle Maynard, Wei Hu, Qiongfang Cao, Michael P. Sheets, Douglas Wilson, Kevin J. Wilson, Lucian DiPietro, Paul Fleming, Michael Palmer, Mimi I. Hu, Lori Wirth, Marcia S. Brose, Sai-Hong Ignatius Ou, Matthew Taylor, Elena Garralda, Stephen Miller, Beni Wolf, Christoph Lengauer, Timothy Guzi and Erica K. Evans
    Cancer Discov July 1 2018 8 (7) 836-849; DOI:10.1158/2159-8290.CD-18-0338

    BLU-667 is a potent selective RET inhibitor with activity against multiple RET mutations and fusions, and it achieved clinical responses with limited toxicity in four patients with RET-driven tumors.

  • Research Articles | AuthorChoice
    NF-κB–Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis
    Paulo Rodrigues, Saroor A. Patel, Louise Harewood, Ioana Olan, Erika Vojtasova, Saiful E. Syafruddin, M. Nazhif Zaini, Emma K. Richardson, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Kourosh Saeb-Parsy, Shamith A. Samarajiwa and Sakari Vanharanta
    Cancer Discov July 1 2018 8 (7) 850-865; DOI:10.1158/2159-8290.CD-17-1211

    High-throughput enhancer profiling identifies metastasis-associated enhancers that are activated to drive CXCR4 expression and metastatic colonization in clear cell renal cell carcinoma.

  • Research Articles
    PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells
    Seong M. Kim, Tricia T. Nguyen, Archna Ravi, Peter Kubiniok, Brendan T. Finicle, Vaishali Jayashankar, Leonel Malacrida, Jue Hou, Jane Robertson, Dong Gao, Jonathan Chernoff, Michelle A. Digman, Eric O. Potma, Bruce J. Tromberg, Pierre Thibault and Aimee L. Edinger
    Cancer Discov July 1 2018 8 (7) 866-883; DOI:10.1158/2159-8290.CD-17-1215

    AMPK-dependent macropinocytosis of necrotic cell debris enhances the growth and survival of PTEN-deficient prostate cancer cells.

  • Research Articles
    CDK6 Antagonizes p53-Induced Responses during Tumorigenesis
    Florian Bellutti, Anca-Sarmiza Tigan, Sofie Nebenfuehr, Marlies Dolezal, Markus Zojer, Reinhard Grausenburger, Svenja Hartenberger, Sebastian Kollmann, Eszter Doma, Michaela Prchal-Murphy, Iris Z. Uras, Alexander Höllein, Donna S. Neuberg, Benjamin L. Ebert, Anna Ringler, Andre C. Mueller, Joanna I. Loizou, Philip W. Hinds, Claus Vogl, Gerwin Heller, Stefan Kubicek, Johannes Zuber, Marcos Malumbres, Matthias Farlik, Andreas Villunger, Karoline Kollmann and Veronika Sexl
    Cancer Discov July 1 2018 8 (7) 884-897; DOI:10.1158/2159-8290.CD-17-0912

    CDK6 antagonizes p53 to promote leukemia cell growth, and CDK6 loss promotes the outgrowth of p53 mutant malignant cell lines, suggesting a potential risk in therapeutic targeting of CDK6.

News in Brief

  • News in Brief
    People
    Cancer Discov July 1 2018 8 (7) 784-784; DOI:10.1158/2159-8290.CD-NB2018-061

  • News in Brief
    Shorter Trastuzumab Course Still Effective
    Cancer Discov July 1 2018 8 (7) 784-784; DOI:10.1158/2159-8290.CD-NB2018-067

  • News in Brief
    Explaining Resistance to CAR T Cells
    Cancer Discov July 1 2018 8 (7) 784-785; DOI:10.1158/2159-8290.CD-NB2018-065

  • News in Brief
    President Signs STAR Act for Kids' Cancers
    Cancer Discov July 1 2018 8 (7) 785-786; DOI:10.1158/2159-8290.CD-NB2018-071

  • News in Brief
    Little Benefit to Breakthrough Cancer Drugs
    Cancer Discov July 1 2018 8 (7) 786-786; DOI:10.1158/2159-8290.CD-NB2018-063

  • News in Brief
    Noted
    Cancer Discov July 1 2018 8 (7) 786-786; DOI:10.1158/2159-8290.CD-NB2018-062

  • News in Brief
    Shared Decision Making Emphasized for Prostate Screening
    Cancer Discov July 1 2018 8 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2018-069

  • News in Brief
    FDA Tackles Underage E-cigarette Use
    Cancer Discov July 1 2018 8 (7) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2018-068

  • News in Brief
    9/11 Firefighters at Risk for Multiple Myeloma
    Cancer Discov July 1 2018 8 (7) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2018-064

  • News in Brief
    Anatomic Gene Expression Atlas Fuels Glioblastoma Discovery
    Cancer Discov July 1 2018 8 (7) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2018-066

News in Depth

  • News in Depth
    The Quest for Off-the-Shelf CAR T Cells
    Cancer Discov July 1 2018 8 (7) 787-788; DOI:10.1158/2159-8290.CD-ND2018-005

  • News in Depth
    Companies Scaling Back IDO1 Inhibitor Trials
    Cancer Discov July 1 2018 8 (7) OF5-OF5; DOI:10.1158/2159-8290.CD-ND2018-007

Research Watch

  • Breast Cancer

    • Research Watch
      p38α Limits Chromosomal Instability in Breast Cancer Cells
      Cancer Discov July 1 2018 8 (7) 792-792; DOI:10.1158/2159-8290.CD-RW2018-095

  • Clinical Trials

    • Research Watch
      The BET Inhibitor Birabresib Is Safe in Patients with Solid Tumors
      Cancer Discov July 1 2018 8 (7) 792-792; DOI:10.1158/2159-8290.CD-RW2018-084

    • Research Watch
      [177Lu]-PSMA-617 Has Activity in Castration-Resistant Prostate Cancer
      Cancer Discov July 1 2018 8 (7) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2018-085

  • Drug Discovery

    • Research Watch
      A Bispecific Antibody Targeting HER2 and HER3 Suppresses Tumor Growth
      Cancer Discov July 1 2018 8 (7) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2018-087

  • Epigenetics

    • Research Watch
      MLL3 Mutations Disrupt COMPASS Recruitment to Enhancer Chromatin
      Cancer Discov July 1 2018 8 (7) 791-791; DOI:10.1158/2159-8290.CD-RW2018-091

    • Research Watch
      UTX Promotes Chromatin Remodeling to Suppress Leukemogenesis
      Cancer Discov July 1 2018 8 (7) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2018-082

  • Immunotherapy

    • Research Watch
      TET2 Disruption Enhances the Efficacy of CD19 CAR T-cell Therapy
      Cancer Discov July 1 2018 8 (7) 793-793; DOI:10.1158/2159-8290.CD-RW2018-098

    • Research Watch
      ARID1A Deficiency May Predict Response to Immune Checkpoint Blockade
      Cancer Discov July 1 2018 8 (7) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2018-083

  • Leukemia

    • Research Watch
      Erasing CD33 in Normal Myeloid Cells Averts CAR T Cell–Driven Toxicity
      Cancer Discov July 1 2018 8 (7) 793-793; DOI:10.1158/2159-8290.CD-RW2018-096

    • Research Watch
      The cis-Regulatory DERARE Element Regulates Leukemogenesis
      Cancer Discov July 1 2018 8 (7) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2018-081

  • Lung Cancer

    • Research Watch
      Targeting Glutaminase May Overcome Resistance to mTOR Inhibition
      Cancer Discov July 1 2018 8 (7) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2018-086

  • Microbiome

    • Research Watch
      Microbial Signals Promote Preleukemic Myeloproliferation in Tet2−/− Mice
      Cancer Discov July 1 2018 8 (7) 789-789; DOI:10.1158/2159-8290.CD-RW2018-090

  • Noncoding RNA

    • Research Watch
      3' UTR Shortening Represses Tumor Suppressor Genes in Trans
      Cancer Discov July 1 2018 8 (7) 790-790; DOI:10.1158/2159-8290.CD-RW2018-092

  • Oxidative Stress

    • Research Watch
      TRPA1-Mediated Ca2+ Influx Protects Tumor Cells from Oxidative Stress
      Cancer Discov July 1 2018 8 (7) 790-790; DOI:10.1158/2159-8290.CD-RW2018-094

  • Pancreatic Cancer

    • Research Watch
      Endoplasmic Reticulum Stress Drives Latent Pancreatic Tumor Metastases
      Cancer Discov July 1 2018 8 (7) 791-791; DOI:10.1158/2159-8290.CD-RW2018-088

  • Prostate Cancer

    • Research Watch
      The lncRNA ARLNC1 Promotes Prostate Tumorigenesis
      Cancer Discov July 1 2018 8 (7) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2018-099

  • Sarcoma

    • Research Watch
      SS18-SSX Retargets the BAF Complex to Drive Synovial Sarcoma
      Cancer Discov July 1 2018 8 (7) 789-789; DOI:10.1158/2159-8290.CD-RW2018-097

  • Signaling

    • Research Watch
      KLHL22 Promotes MTORC1 Activation and Breast Tumorigenesis
      Cancer Discov July 1 2018 8 (7) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2018-089

  • Structural Biology

    • Research Watch
      Cholesterol-Induced Conformational Changes Drive Smoothened Activation
      Cancer Discov July 1 2018 8 (7) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2018-093

  • Tumor Suppressors

    • Research Watch
      The PVT1 Promoter Suppresses MYC Transcription to Reduce Cell Growth
      Cancer Discov July 1 2018 8 (7) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2018-080

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Cancer Discovery: 8 (7)
July 2018
Volume 8, Issue 7
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