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Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov August 1 2018 8 (8) 899-902; DOI:10.1158/2159-8290.CD-ITI8-8

In the Spotlight

  • In the Spotlight
    Engineered T Cells in Synovial Sarcoma: Persistence Pays Off!
    Emily Z. Keung and Hussein A. Tawbi
    Cancer Discov August 1 2018 8 (8) 914-917; DOI:10.1158/2159-8290.CD-18-0618

  • In the Spotlight
    CAR T-cell Integration of Multiple Input Signals Allows for Precise Targeting of Cancer
    Daniela Achkova and Martin Pule
    Cancer Discov August 1 2018 8 (8) 918-920; DOI:10.1158/2159-8290.CD-18-0672

  • In the Spotlight
    MACROD2, an Original Cause of CIN?
    Ning Jin and Mark E. Burkard
    Cancer Discov August 1 2018 8 (8) 921-923; DOI:10.1158/2159-8290.CD-18-0674

Review

  • Review
    CARs versus BiTEs: A Comparison between T Cell–Redirection Strategies for Cancer Treatment
    Clare Y. Slaney, Pin Wang, Phillip K. Darcy and Michael H. Kershaw
    Cancer Discov August 1 2018 8 (8) 924-934; DOI:10.1158/2159-8290.CD-18-0297

Research Brief

  • Research Brief
    Immunotherapy Resistance by Inflammation-Induced Dedifferentiation
    Arnav Mehta, Yeon Joo Kim, Lidia Robert, Jennifer Tsoi, Begoña Comin-Anduix, Beata Berent-Maoz, Alistair J. Cochran, James S. Economou, Paul C. Tumeh, Cristina Puig-Saus and Antoni Ribas
    Cancer Discov August 1 2018 8 (8) 935-943; DOI:10.1158/2159-8290.CD-17-1178

    A patient with metastatic melanoma initially responded after adoptive T-cell transfer, but an inflammation-induced melanoma cell dedifferentiation resulted in loss of the MART1 tumor antigen and tumor relapse.

Research Articles

  • Research Articles | AuthorChoice
    Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259T Cells in Synovial Sarcoma
    Sandra P. D'Angelo, Luca Melchiori, Melinda S. Merchant, Donna Bernstein, John Glod, Rosandra Kaplan, Stephan Grupp, William D. Tap, Karen Chagin, Gwendolyn K. Binder, Samik Basu, Daniel E. Lowther, Ruoxi Wang, Natalie Bath, Alex Tipping, Gareth Betts, Indu Ramachandran, Jean-Marc Navenot, Hua Zhang, Daniel K. Wells, Erin Van Winkle, Gabor Kari, Trupti Trivedi, Tom Holdich, Lini Pandite, Rafael Amado and Crystal L. Mackall
    Cancer Discov August 1 2018 8 (8) 944-957; DOI:10.1158/2159-8290.CD-17-1417

    In a prospective clinical study of 12 patients with synovial sarcoma, adoptive transfer of autologous NY-ESO-1c259 cells resulted in a 50% objective response rate and long-term persistence of a clonally diverse, fully functional NY-ESO-1c259 cells.

  • Research Articles | AuthorChoice
    Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia
    Bianca D. Santomasso, Jae H. Park, Darin Salloum, Isabelle Riviere, Jessica Flynn, Elena Mead, Elizabeth Halton, Xiuyan Wang, Brigitte Senechal, Terence Purdon, Justin R. Cross, Hui Liu, Behroze Vachha, Xi Chen, Lisa M. DeAngelis, Daniel Li, Yvette Bernal, Mithat Gonen, Hans-Guido Wendel, Michel Sadelain and Renier J. Brentjens
    Cancer Discov August 1 2018 8 (8) 958-971; DOI:10.1158/2159-8290.CD-17-1319

    Elevation of proinflammatory cytokines and disruption of blood-CSF barrier are associated with CAR T cell-driven neurotoxicity in patients with B-ALL who were treated with CD19 CAR 19-28ζ T cells.

  • Research Articles
    Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
    Sujita Sukumaran, Norihiro Watanabe, Pradip Bajgain, Kanchana Raja, Somala Mohammed, William E. Fisher, Malcolm K. Brenner, Ann M. Leen and Juan F. Vera
    Cancer Discov August 1 2018 8 (8) 972-987; DOI:10.1158/2159-8290.CD-17-1298

    CAR T cells engineered to recognize three independent tumor antigens for activation, costimulation, and cytokine support limit on-target, off-tumor toxicity for enhanced antitumor efficacy and safety.

  • Research Articles
    MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors
    Anuratha Sakthianandeswaren, Marie J. Parsons, Dmitri Mouradov, Ruth N. MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N. Jorissen, Shan Li, Lachlan Whitehead, Tracy L. Putoczki, Adele Preaudet, Cary Tsui, Cameron J. Nowell, Robyn L. Ward, Nicholas J. Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, Ian Street, Michael Buchert and Oliver M. Sieber
    Cancer Discov August 1 2018 8 (8) 988-1005; DOI:10.1158/2159-8290.CD-17-0909

    Deletions of the mono-ADP-ribosylhydrolase gene MACROD2 enhance intestinal tumorigenesis in a haploinsufficient manner by suppressing PARP1 activity, leading to increased sensitivity to DNA damage and driving chromosome instability.

  • Research Articles | AuthorChoice
    Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins
    Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero and Richard M. White
    Cancer Discov August 1 2018 8 (8) 1006-1025; DOI:10.1158/2159-8290.CD-17-1371

    Melanoma tumorigenesis is accelerated by the uptake of long-chain fatty acids from adipocytes via the FATP1 lipid transporter, and this adipocyte-melanoma cell cross-talk may by disrupted by FATP inhibitors.

  • Research Articles | AuthorChoice
    YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity
    Xuhao Ni, Jinhui Tao, Joseph Barbi, Qian Chen, Benjamin V. Park, Zhiguang Li, Nailing Zhang, Andriana Lebid, Anjali Ramaswamy, Ping Wei, Ying Zheng, Xuehong Zhang, Xingmei Wu, Paolo Vignali, Cui-Ping Yang, Huabin Li, Drew Pardoll, Ling Lu, Duojia Pan and Fan Pan
    Cancer Discov August 1 2018 8 (8) 1026-1043; DOI:10.1158/2159-8290.CD-17-1124

    YAP expression in Treg cells upregulates the activin receptor to enhance SMAD/TGFβ signaling, promote Treg differentiation, and suppress antitumor immunity, suggesting potential immunotherapeutic targets.

News in Brief

  • News in Brief
    People
    Cancer Discov August 1 2018 8 (8) 904-904; DOI:10.1158/2159-8290.CD-NB2018-080

  • News in Brief
    Pembrolizumab OK'd for Cervical Cancer
    Cancer Discov August 1 2018 8 (8) 904-904; DOI:10.1158/2159-8290.CD-NB2018-086

  • News in Brief
    LOXO-292 Reins In RET-Driven Tumors
    Cancer Discov August 1 2018 8 (8) 904-905; DOI:10.1158/2159-8290.CD-NB2018-070

  • News in Brief
    Antibiotics Protect against Liver Tumors in Mice
    Cancer Discov August 1 2018 8 (8) 905-906; DOI:10.1158/2159-8290.CD-NB2018-078

  • News in Brief
    Sequencing Detects Lung Cancer in Blood
    Cancer Discov August 1 2018 8 (8) 906-906; DOI:10.1158/2159-8290.CD-NB2018-075

  • News in Brief
    Lynch Syndrome Linked with More Cancers
    Cancer Discov August 1 2018 8 (8) 906-907; DOI:10.1158/2159-8290.CD-NB2018-073

  • News in Brief
    By the Numbers: Cancer Mortality, 2011–2015
    Cancer Discov August 1 2018 8 (8) 907-907; DOI:10.1158/2159-8290.CD-NB2018-094

  • News in Brief
    Roche to Buy Balance of Foundation Medicine
    Cancer Discov August 1 2018 8 (8) 907-908; DOI:10.1158/2159-8290.CD-NB2018-087

  • News in Brief
    Upping Enrollment of Veterans in Trials
    Cancer Discov August 1 2018 8 (8) 908-908; DOI:10.1158/2159-8290.CD-NB2018-097

  • News in Brief
    Noted
    Cancer Discov August 1 2018 8 (8) 908-908; DOI:10.1158/2159-8290.CD-NB2018-081

  • News in Brief
    Study Reveals Germline Genetics of Medulloblastoma
    Cancer Discov August 1 2018 8 (8) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2018-079

  • News in Brief
    Quizartinib Bests Chemo for FLT3-Mutant AML
    Cancer Discov August 1 2018 8 (8) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2018-090

  • News in Brief
    Positive Results for Tazemetostat in Follicular Lymphoma
    Cancer Discov August 1 2018 8 (8) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2018-088

  • News in Brief
    Abiraterone–Olaparib Combo Aids Men with mCRPC
    Cancer Discov August 1 2018 8 (8) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2018-084

  • News in Brief
    Trastuzumab Deruxtecan Targets HER2+ Cancers
    Cancer Discov August 1 2018 8 (8) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2018-083

  • News in Brief
    Erdafitinib Efficacious in Bladder Cancer
    Cancer Discov August 1 2018 8 (8) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2018-085

  • News in Brief
    Ivosidenib Deemed Safe, Effective in AML
    Cancer Discov August 1 2018 8 (8) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2018-082

  • News in Brief
    An Immunosuppressive Role for Eya3 in TNBC
    Cancer Discov August 1 2018 8 (8) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2018-072

  • News in Brief
    Pembrolizumab Monotherapy for NSCLC Extends Survival
    Cancer Discov August 1 2018 8 (8) OF9-OF9; DOI:10.1158/2159-8290.CD-NB2018-074

  • News in Brief
    Squamous NSCLC Improves with Atezolizumab Plus Chemo
    Cancer Discov August 1 2018 8 (8) OF10-OF10; DOI:10.1158/2159-8290.CD-NB2018-077

  • News in Brief
    Maintenance Chemo Improves Pediatric RMS
    Cancer Discov August 1 2018 8 (8) OF11-OF11; DOI:10.1158/2159-8290.CD-NB2018-076

Research Watch

  • Clinical Trials

    • Research Watch
      Cemiplimab Achieves Responses in Cutaneous Squamous Cell Carcinoma
      Cancer Discov August 1 2018 8 (8) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2018-100

  • Drug Evaluation

    • Research Watch
      An OXPHOS Inhibitor Has Antitumor Activity in Multiple Tumor Models
      Cancer Discov August 1 2018 8 (8) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2018-106

  • Drug Discovery

    • Research Watch
      Master Regulators May Be Therapeutic Targets for Precision Oncology
      Cancer Discov August 1 2018 8 (8) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2018-107

  • Drug Resistance

    • Research Watch
      Second-Site IDH2 Mutations Confer Resistance to Enasidenib In Trans
      Cancer Discov August 1 2018 8 (8) 913-913; DOI:10.1158/2159-8290.CD-RW2018-114

  • Genomics

    • Research Watch
      Paralog Dependency May Be Exploitable in Tumors Lacking Chromosome 1p
      Cancer Discov August 1 2018 8 (8) 909-909; DOI:10.1158/2159-8290.CD-RW2018-112

  • Immunology

    • Research Watch
      The Histone Demethylase LSD1 Inhibits Tumor Cell Immunogenicity
      Cancer Discov August 1 2018 8 (8) 911-911; DOI:10.1158/2159-8290.CD-RW2018-108

    • Research Watch
      Mitophagy in Gut Epithelial Cells Promotes Antitumor Immunity
      Cancer Discov August 1 2018 8 (8) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2018-104

  • Immunotherapy

    • Research Watch
      Autologous T Cells Targeting Four Neoantigens Induce Tumor Regression
      Cancer Discov August 1 2018 8 (8) 909-909; DOI:10.1158/2159-8290.CD-RW2018-101

    • Research Watch
      IL1 Blockade May Ameliorate Cytokine Release Syndrome
      Cancer Discov August 1 2018 8 (8) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2018-102

  • Leukemia

    • Research Watch
      CBFβ–SMMHC Activates MYC Enhancers to Promote Leukemogenesis
      Cancer Discov August 1 2018 8 (8) 913-913; DOI:10.1158/2159-8290.CD-RW2018-113

  • Medulloblastoma

    • Research Watch
      BAI1 Stabilizes p53 to Suppress Medulloblastoma Tumorigenesis
      Cancer Discov August 1 2018 8 (8) 912-912; DOI:10.1158/2159-8290.CD-RW2018-103

  • Prostate Cancer

    • Research Watch
      IL23 Produced by MDSCs Promotes Castration-Resistant Prostate Cancer
      Cancer Discov August 1 2018 8 (8) 912-912; DOI:10.1158/2159-8290.CD-RW2018-115

    • Research Watch
      AR Enhancer Amplification Drives Castration-Resistant Prostate Cancer
      Cancer Discov August 1 2018 8 (8) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2018-105

  • Transcription

    • Research Watch
      Phase Separation Concentrates Transcription Proteins at Superenhancers
      Cancer Discov August 1 2018 8 (8) 911-911; DOI:10.1158/2159-8290.CD-RW2018-110

    • Research Watch
      Transcription Factor Low-Complexity Domain Hubs Drive Transcription
      Cancer Discov August 1 2018 8 (8) 910-910; DOI:10.1158/2159-8290.CD-RW2018-111

  • Translation

    • Research Watch
      Enzymes That Catalyze Wobble tRNA Modification Promote Melanomagenesis
      Cancer Discov August 1 2018 8 (8) 910-910; DOI:10.1158/2159-8290.CD-RW2018-109

Corrections

  • Corrections | Free Article
    Correction: Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer
    Cancer Discov August 1 2018 8 (8) 1044-1044; DOI:10.1158/2159-8290.CD-18-0709

  • Corrections | Free Article
    Correction: Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
    Cancer Discov August 1 2018 8 (8) 1045-1045; DOI:10.1158/2159-8290.CD-18-0714

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Cancer Discovery: 8 (8)
August 2018
Volume 8, Issue 8
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