Table of Contents

Research Articles

• Research Articles | AuthorChoice

  Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 ^c259T Cells in Synovial Sarcoma

  Sandra P. D'Angelo, Luca Melchiori, Melinda S. Merchant, Donna Bernstein, John Glod, Rosandra Kaplan, Stephan Grupp, William D. Tap, Karen Chagin, Gwendolyn K. Binder, Samik Basu, Daniel E. Lowther, Ruoxi Wang, Natalie Bath, Alex Tipping, Gareth Betts, Indu Ramachandran, Jean-Marc Navenot, Hua Zhang, Daniel K. Wells, Erin Van Winkle, Gabor Kari, Trupti Trivedi, Tom Holdich, Lini Pandite, Rafael Amado and Crystal L. Mackall

  Cancer Discov August 1 2018 8 (8) 944-957; DOI:10.1158/2159-8290.CD-17-1417

  
  

  In a prospective clinical study of 12 patients with synovial sarcoma, adoptive transfer of autologous NY-ESO-1^c259 cells resulted in a 50% objective response rate and long-term persistence of a clonally diverse, fully functional NY-ESO-1^c259 cells.

• Research Articles | AuthorChoice

  Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

  Bianca D. Santomasso, Jae H. Park, Darin Salloum, Isabelle Riviere, Jessica Flynn, Elena Mead, Elizabeth Halton, Xiuyan Wang, Brigitte Senechal, Terence Purdon, Justin R. Cross, Hui Liu, Behroze Vachha, Xi Chen, Lisa M. DeAngelis, Daniel Li, Yvette Bernal, Mithat Gonen, Hans-Guido Wendel, Michel Sadelain and Renier J. Brentjens

  Cancer Discov August 1 2018 8 (8) 958-971; DOI:10.1158/2159-8290.CD-17-1319

  
  

  Elevation of proinflammatory cytokines and disruption of blood-CSF barrier are associated with CAR T cell-driven neurotoxicity in patients with B-ALL who were treated with CD19 CAR 19-28ζ T cells.

• Research Articles

  Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment

  Sujita Sukumaran, Norihiro Watanabe, Pradip Bajgain, Kanchana Raja, Somala Mohammed, William E. Fisher, Malcolm K. Brenner, Ann M. Leen and Juan F. Vera

  Cancer Discov August 1 2018 8 (8) 972-987; DOI:10.1158/2159-8290.CD-17-1298

  
  

  CAR T cells engineered to recognize three independent tumor antigens for activation, costimulation, and cytokine support limit on-target, off-tumor toxicity for enhanced antitumor efficacy and safety.

• Research Articles

  MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

  Anuratha Sakthianandeswaren, Marie J. Parsons, Dmitri Mouradov, Ruth N. MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N. Jorissen, Shan Li, Lachlan Whitehead, Tracy L. Putoczki, Adele Preaudet, Cary Tsui, Cameron J. Nowell, Robyn L. Ward, Nicholas J. Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, Ian Street, Michael Buchert and Oliver M. Sieber

  Cancer Discov August 1 2018 8 (8) 988-1005; DOI:10.1158/2159-8290.CD-17-0909

  
  

  Deletions of the mono-ADP-ribosylhydrolase gene MACROD2 enhance intestinal tumorigenesis in a haploinsufficient manner by suppressing PARP1 activity, leading to increased sensitivity to DNA damage and driving chromosome instability.

• Research Articles | AuthorChoice

  Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

  Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero and Richard M. White

  Cancer Discov August 1 2018 8 (8) 1006-1025; DOI:10.1158/2159-8290.CD-17-1371

  
  

  Melanoma tumorigenesis is accelerated by the uptake of long-chain fatty acids from adipocytes via the FATP1 lipid transporter, and this adipocyte-melanoma cell cross-talk may by disrupted by FATP inhibitors.

• Research Articles | AuthorChoice

  YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

  Xuhao Ni, Jinhui Tao, Joseph Barbi, Qian Chen, Benjamin V. Park, Zhiguang Li, Nailing Zhang, Andriana Lebid, Anjali Ramaswamy, Ping Wei, Ying Zheng, Xuehong Zhang, Xingmei Wu, Paolo Vignali, Cui-Ping Yang, Huabin Li, Drew Pardoll, Ling Lu, Duojia Pan and Fan Pan

  Cancer Discov August 1 2018 8 (8) 1026-1043; DOI:10.1158/2159-8290.CD-17-1124

  
  

  YAP expression in Treg cells upregulates the activin receptor to enhance SMAD/TGFβ signaling, promote Treg differentiation, and suppress antitumor immunity, suggesting potential immunotherapeutic targets.