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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov January 1 2019 9 (1) 1-4; DOI:10.1158/2159-8290.CD-ITI9-1

In the Spotlight

  • In the Spotlight
    Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers
    Carminia Maria Della Corte and Lauren Averett Byers
    Cancer Discov January 1 2019 9 (1) 16-18; DOI:10.1158/2159-8290.CD-18-1286

  • In the Spotlight
    Something Old, Something New: The Tumor Microenvironment Comes of Age
    Kerrie L. Marie and Glenn Merlino
    Cancer Discov January 1 2019 9 (1) 19-21; DOI:10.1158/2159-8290.CD-18-1320

  • In the Spotlight
    Circulating Tumor Cells: Come Together, Right Now, Over Metastasis
    Paulo Rodrigues and Sakari Vanharanta
    Cancer Discov January 1 2019 9 (1) 22-24; DOI:10.1158/2159-8290.CD-18-1285

Mini Review

  • Mini Review
    The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis
    Ly P. Vu, Yuanming Cheng and Michael G. Kharas
    Cancer Discov January 1 2019 9 (1) 25-33; DOI:10.1158/2159-8290.CD-18-0959

Research Brief

  • Research Brief
    Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
    Shunsuke Kitajima, Elena Ivanova, Sujuan Guo, Ryohei Yoshida, Marco Campisi, Shriram K. Sundararaman, Shoichiro Tange, Yoichiro Mitsuishi, Tran C. Thai, Sayuri Masuda, Brandon P. Piel, Lynette M. Sholl, Paul T. Kirschmeier, Cloud P. Paweletz, Hideo Watanabe, Mamiko Yajima and David A. Barbie
    Cancer Discov January 1 2019 9 (1) 34-45; DOI:10.1158/2159-8290.CD-18-0689

    Loss of LKB1 in KRAS-mutant lung cancer results in SAM-mediated activation of DNMT1 and EZH2, which subsequently represses the expression of STING and PD-L1 to promote immune escape.

Research Articles

  • Research Articles | AuthorChoice
    Genome-Informed Targeted Therapy for Osteosarcoma
    Leanne C. Sayles, Marcus R. Breese, Amanda L. Koehne, Stanley G. Leung, Alex G. Lee, Heng-Yi Liu, Aviv Spillinger, Avanthi T. Shah, Bogdan Tanasa, Krystal Straessler, Florette K. Hazard, Sheri L. Spunt, Neyssa Marina, Grace E. Kim, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Mi-Ok Kim, Steven G. DuBois, Douglas S. Hawkins and E. Alejandro Sweet-Cordero
    Cancer Discov January 1 2019 9 (1) 46-63; DOI:10.1158/2159-8290.CD-17-1152

    Genomic characterization and the establishment of patient-derived xenografts identify therapeutic targets within recurrent SCNAs in osteosarcoma subclasses.

  • Research Articles
    Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
    Amanpreet Kaur, Brett L. Ecker, Stephen M. Douglass, Curtis H. Kugel III, Marie R. Webster, Filipe V. Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A. Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W. Speicher, Jennifer A. Wargo, Michael T. Tetzlaff, Lauren E. Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman and Ashani T. Weeraratna
    Cancer Discov January 1 2019 9 (1) 64-81; DOI:10.1158/2159-8290.CD-18-0193

    Loss of the cross-linking protein HAPLN1 in skin fibroblasts during aging results in changes to the extracellular matrix architecture that enhance melanoma cell invasion but impair immune cell infiltration.

  • Research Articles
    Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis
    Brett L. Ecker, Amanpreet Kaur, Stephen M. Douglass, Marie R. Webster, Filipe V. Almeida, Gloria E. Marino, Andrew J. Sinnamon, Madalyn G. Neuwirth, Gretchen M. Alicea, Abibatou Ndoye, Mitchell Fane, Xiaowei Xu, Myung Shin Sim, Gary B. Deutsch, Mark B. Faries, Giorgos C. Karakousis and Ashani T. Weeraratna
    Cancer Discov January 1 2019 9 (1) 82-95; DOI:10.1158/2159-8290.CD-18-0168

    Changes in ECM degradation and lymphatic vasculature permeability during aging are mediated by the cross-linking protein HAPLN1 and determine the route of metastatic dissemination.

  • Research Articles | AuthorChoice
    Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models
    Xia Liu, Rokana Taftaf, Madoka Kawaguchi, Ya-Fang Chang, Wenjing Chen, David Entenberg, Youbin Zhang, Lorenzo Gerratana, Simo Huang, Dhwani B. Patel, Elizabeth Tsui, Valery Adorno-Cruz, Steven M. Chirieleison, Yue Cao, Allison S. Harney, Shivani Patel, Antonia Patsialou, Yang Shen, Stefanie Avril, Hannah L. Gilmore, Justin D. Lathia, Derek W. Abbott, Massimo Cristofanilli, John S. Condeelis and Huiping Liu
    Cancer Discov January 1 2019 9 (1) 96-113; DOI:10.1158/2159-8290.CD-18-0065

    Intercellular homophilic CD44 interaction–mediated tumor cell aggregation recruits PAK2 and activates the PAK2 signaling pathway to drive tumorigenesis and polyclonal metastasis.

  • Research Articles | AuthorChoice
    Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
    Zhiguo Chen, Juan Mo, Jean-Philippe Brosseau, Tracey Shipman, Yong Wang, Chung-Ping Liao, Jonathan M. Cooper, Robert J. Allaway, Sara J.C. Gosline, Justin Guinney, Thomas J. Carroll and Lu Q. Le
    Cancer Discov January 1 2019 9 (1) 114-129; DOI:10.1158/2159-8290.CD-18-0151

    Inactivation of Nf1 in a Hoxb7-expressing cell lineage faithfully models neurofi bromagenesis and provides insights into the developmental origin of both plexiform and cutaneous neurofi broma.

  • Research Articles
    Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells
    Katarzyna J. Radomska, Fanny Coulpier, Aurelie Gresset, Alain Schmitt, Amal Debbiche, Sophie Lemoine, Pierre Wolkenstein, Jean-Michel Vallat, Patrick Charnay and Piotr Topilko
    Cancer Discov January 1 2019 9 (1) 130-147; DOI:10.1158/2159-8290.CD-18-0156

    Loss of Nf1 in Prss56-expressing boundary cap cells recapitulates both cutaneous and plexiform neurofi broma and provides insight into neurofi bromagenesis.

News in Brief

  • News in Brief
    People
    Cancer Discov January 1 2019 9 (1) 6-6; DOI:10.1158/2159-8290.CD-NB2018-149

  • News in Brief
    Two-Drug Cocktail Active against RCC
    Cancer Discov January 1 2019 9 (1) 6-6; DOI:10.1158/2159-8290.CD-NB2018-152

  • News in Brief
    Alpelisib Extends PFS in PIK3CA-Mutant Breast Cancer
    Cancer Discov January 1 2019 9 (1) 6-7; DOI:10.1158/2159-8290.CD-NB2018-146

  • News in Brief
    Anti-CD47 Agent Boosts Macrophage Activity in NHL
    Cancer Discov January 1 2019 9 (1) 7-8; DOI:10.1158/2159-8290.CD-NB2018-155

  • News in Brief
    ZW25 Effective in HER2-Positive Cancers
    Cancer Discov January 1 2019 9 (1) 8-8; DOI:10.1158/2159-8290.CD-NB2018-162

  • News in Brief
    Larotrectinib OK'd for Cancers with TRK Fusions
    Cancer Discov January 1 2019 9 (1) 8-9; DOI:10.1158/2159-8290.CD-NB2018-163

  • News in Brief
    Noted
    Cancer Discov January 1 2019 9 (1) 9-9; DOI:10.1158/2159-8290.CD-NB2018-150

  • News in Brief
    Cancer Research Driven by Patients and Technology
    Cancer Discov January 1 2019 9 (1) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2018-161

  • News in Brief
    Mixed Reviews for A2AR Inhibitor in NSCLC
    Cancer Discov January 1 2019 9 (1) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2018-157

  • News in Brief
    FDA Seeks Tighter Restrictions on E-cigarettes
    Cancer Discov January 1 2019 9 (1) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2018-158

  • News in Brief
    Entrectinib Effective across NTRK Fusion–Positive Cancers
    Cancer Discov January 1 2019 9 (1) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2018-156

  • News in Brief
    PD-L1 Inhibitor Improves Survival in TNBC
    Cancer Discov January 1 2019 9 (1) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2018-154

  • News in Brief
    Capmatinib Triggers Responses in NSCLC
    Cancer Discov January 1 2019 9 (1) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2018-148

  • News in Brief
    Capivasertib Active against AKT1-Mutated Cancers
    Cancer Discov January 1 2019 9 (1) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2018-153

  • News in Brief
    Pembro Ups Survival in PD-L1–positive HNSCC
    Cancer Discov January 1 2019 9 (1) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2018-151

News in Depth

  • News in Depth
    A Deep Dive into Immunotherapy Resistance
    Cancer Discov January 1 2019 9 (1) 10-10; DOI:10.1158/2159-8290.CD-ND2018-010

Research Watch

  • Clinical Trials

    • Research Watch
      Targeting BCMA Achieves Deep and Durable Responses in Multiple Myeloma
      Cancer Discov January 1 2019 9 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2018-203

    • Research Watch
      Pembrolizumab Produces Durable Responses in Melanoma Brain Metastases
      Cancer Discov January 1 2019 9 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2018-198

  • Drug Resistance

    • Research Watch
      SWI/SNF Mutations Confer Resistance to Ibrutinib plus Venetoclax in MCL
      Cancer Discov January 1 2019 9 (1) 15-15; DOI:10.1158/2159-8290.CD-RW2018-210

  • Hematopoiesis

    • Research Watch
      JARID2 Is a Tumor Suppressor in Myeloid Neoplasms
      Cancer Discov January 1 2019 9 (1) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2018-208

  • Immunology

    • Research Watch
      The Metabolite BH4 Drives T-cell Growth in Autoimmunity and Cancer
      Cancer Discov January 1 2019 9 (1) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2018-202

    • Research Watch
      Antiviral- and Antitumor-Specific T-cell Immunity Is WDFY4-Dependent
      Cancer Discov January 1 2019 9 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2018-206

  • Immunotherapy

    • Research Watch
      Radiotherapy May Sensitize to CTLA4 Blockade in Patients with NSCLC
      Cancer Discov January 1 2019 9 (1) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2018-204

    • Research Watch
      HIP1R Is a Negative Regulator of PD-L1
      Cancer Discov January 1 2019 9 (1) 14-14; DOI:10.1158/2159-8290.CD-RW2018-200

    • Research Watch
      A Developed STING Agonist Has Systemic Antitumor Activity
      Cancer Discov January 1 2019 9 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2018-201

  • Leukemia

    • Research Watch
      CHAF1B Suppresses Myeloid Differentiation to Promote Leukemogenesis
      Cancer Discov January 1 2019 9 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2018-207

  • Metabolism

    • Research Watch
      Autophagy Sustains Tumors by Maintaining Serum Arginine Levels
      Cancer Discov January 1 2019 9 (1) 15-15; DOI:10.1158/2159-8290.CD-RW2018-209

  • Metastasis

    • Research Watch
      Osteogenic Cells Supply Calcium to Tumor Cells to Enhance Bone Metastasis
      Cancer Discov January 1 2019 9 (1) 14-14; DOI:10.1158/2159-8290.CD-RW2018-205

  • Oncogenes

    • Research Watch
      Two MYC Homology Boxes Drive Tumorigenesis
      Cancer Discov January 1 2019 9 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2018-199

  • Prostate Cancer

    • Research Watch
      ONECUT2 Is a Key Node and Therapeutic Target in Lethal Prostate Cancer
      Cancer Discov January 1 2019 9 (1) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2018-211

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers
    Acknowledgment to Reviewers
    Cancer Discov January 1 2019 9 (1) 148-149; DOI:10.1158/2159-8290.CD-9-1-Reviewers

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Cancer Discovery: 9 (1)
January 2019
Volume 9, Issue 1
  • Table of Contents
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