Table of Contents
In This Issue
In the Spotlight
- In the SpotlightCarminia Maria Della Corte and Lauren Averett ByersCancer Discov January 1 2019 9 (1) 16-18; DOI:10.1158/2159-8290.CD-18-1286
- In the SpotlightKerrie L. Marie and Glenn MerlinoCancer Discov January 1 2019 9 (1) 19-21; DOI:10.1158/2159-8290.CD-18-1320
- In the SpotlightPaulo Rodrigues and Sakari VanharantaCancer Discov January 1 2019 9 (1) 22-24; DOI:10.1158/2159-8290.CD-18-1285
Mini Review
- Mini ReviewLy P. Vu, Yuanming Cheng and Michael G. KharasCancer Discov January 1 2019 9 (1) 25-33; DOI:10.1158/2159-8290.CD-18-0959
Research Brief
- Research BriefShunsuke Kitajima, Elena Ivanova, Sujuan Guo, Ryohei Yoshida, Marco Campisi, Shriram K. Sundararaman, Shoichiro Tange, Yoichiro Mitsuishi, Tran C. Thai, Sayuri Masuda, Brandon P. Piel, Lynette M. Sholl, Paul T. Kirschmeier, Cloud P. Paweletz, Hideo Watanabe, Mamiko Yajima and David A. BarbieCancer Discov January 1 2019 9 (1) 34-45; DOI:10.1158/2159-8290.CD-18-0689
Loss of LKB1 in KRAS-mutant lung cancer results in SAM-mediated activation of DNMT1 and EZH2, which subsequently represses the expression of STING and PD-L1 to promote immune escape.
Research Articles
- Research Articles | AuthorChoiceLeanne C. Sayles, Marcus R. Breese, Amanda L. Koehne, Stanley G. Leung, Alex G. Lee, Heng-Yi Liu, Aviv Spillinger, Avanthi T. Shah, Bogdan Tanasa, Krystal Straessler, Florette K. Hazard, Sheri L. Spunt, Neyssa Marina, Grace E. Kim, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Mi-Ok Kim, Steven G. DuBois, Douglas S. Hawkins and E. Alejandro Sweet-CorderoCancer Discov January 1 2019 9 (1) 46-63; DOI:10.1158/2159-8290.CD-17-1152
Genomic characterization and the establishment of patient-derived xenografts identify therapeutic targets within recurrent SCNAs in osteosarcoma subclasses.
- Research ArticlesAmanpreet Kaur, Brett L. Ecker, Stephen M. Douglass, Curtis H. Kugel III, Marie R. Webster, Filipe V. Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A. Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W. Speicher, Jennifer A. Wargo, Michael T. Tetzlaff, Lauren E. Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman and Ashani T. WeeraratnaCancer Discov January 1 2019 9 (1) 64-81; DOI:10.1158/2159-8290.CD-18-0193
Loss of the cross-linking protein HAPLN1 in skin fibroblasts during aging results in changes to the extracellular matrix architecture that enhance melanoma cell invasion but impair immune cell infiltration.
- Research ArticlesBrett L. Ecker, Amanpreet Kaur, Stephen M. Douglass, Marie R. Webster, Filipe V. Almeida, Gloria E. Marino, Andrew J. Sinnamon, Madalyn G. Neuwirth, Gretchen M. Alicea, Abibatou Ndoye, Mitchell Fane, Xiaowei Xu, Myung Shin Sim, Gary B. Deutsch, Mark B. Faries, Giorgos C. Karakousis and Ashani T. WeeraratnaCancer Discov January 1 2019 9 (1) 82-95; DOI:10.1158/2159-8290.CD-18-0168
Changes in ECM degradation and lymphatic vasculature permeability during aging are mediated by the cross-linking protein HAPLN1 and determine the route of metastatic dissemination.
- Research Articles | AuthorChoiceXia Liu, Rokana Taftaf, Madoka Kawaguchi, Ya-Fang Chang, Wenjing Chen, David Entenberg, Youbin Zhang, Lorenzo Gerratana, Simo Huang, Dhwani B. Patel, Elizabeth Tsui, Valery Adorno-Cruz, Steven M. Chirieleison, Yue Cao, Allison S. Harney, Shivani Patel, Antonia Patsialou, Yang Shen, Stefanie Avril, Hannah L. Gilmore, Justin D. Lathia, Derek W. Abbott, Massimo Cristofanilli, John S. Condeelis and Huiping LiuCancer Discov January 1 2019 9 (1) 96-113; DOI:10.1158/2159-8290.CD-18-0065
Intercellular homophilic CD44 interaction–mediated tumor cell aggregation recruits PAK2 and activates the PAK2 signaling pathway to drive tumorigenesis and polyclonal metastasis.
- Research Articles | AuthorChoiceZhiguo Chen, Juan Mo, Jean-Philippe Brosseau, Tracey Shipman, Yong Wang, Chung-Ping Liao, Jonathan M. Cooper, Robert J. Allaway, Sara J.C. Gosline, Justin Guinney, Thomas J. Carroll and Lu Q. LeCancer Discov January 1 2019 9 (1) 114-129; DOI:10.1158/2159-8290.CD-18-0151
Inactivation of Nf1 in a Hoxb7-expressing cell lineage faithfully models neurofi bromagenesis and provides insights into the developmental origin of both plexiform and cutaneous neurofi broma.
- Research ArticlesKatarzyna J. Radomska, Fanny Coulpier, Aurelie Gresset, Alain Schmitt, Amal Debbiche, Sophie Lemoine, Pierre Wolkenstein, Jean-Michel Vallat, Patrick Charnay and Piotr TopilkoCancer Discov January 1 2019 9 (1) 130-147; DOI:10.1158/2159-8290.CD-18-0156
Loss of Nf1 in Prss56-expressing boundary cap cells recapitulates both cutaneous and plexiform neurofi broma and provides insight into neurofi bromagenesis.
News in Brief
- News in BriefCancer Discov January 1 2019 9 (1) 6-6; DOI:10.1158/2159-8290.CD-NB2018-152
- News in BriefCancer Discov January 1 2019 9 (1) 6-7; DOI:10.1158/2159-8290.CD-NB2018-146
- News in BriefCancer Discov January 1 2019 9 (1) 7-8; DOI:10.1158/2159-8290.CD-NB2018-155
- News in BriefCancer Discov January 1 2019 9 (1) 8-8; DOI:10.1158/2159-8290.CD-NB2018-162
- News in BriefCancer Discov January 1 2019 9 (1) 8-9; DOI:10.1158/2159-8290.CD-NB2018-163
- News in BriefCancer Discov January 1 2019 9 (1) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2018-161
- News in BriefCancer Discov January 1 2019 9 (1) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2018-157
- News in BriefCancer Discov January 1 2019 9 (1) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2018-158
- News in BriefCancer Discov January 1 2019 9 (1) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2018-156
- News in BriefCancer Discov January 1 2019 9 (1) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2018-154
- News in BriefCancer Discov January 1 2019 9 (1) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2018-148
- News in BriefCancer Discov January 1 2019 9 (1) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2018-153
- News in BriefCancer Discov January 1 2019 9 (1) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2018-151
News in Depth
- News in DepthCancer Discov January 1 2019 9 (1) 10-10; DOI:10.1158/2159-8290.CD-ND2018-010
Research Watch
Clinical Trials
- Research WatchCancer Discov January 1 2019 9 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2018-203
- Research WatchCancer Discov January 1 2019 9 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2018-198
Drug Resistance
- Research WatchCancer Discov January 1 2019 9 (1) 15-15; DOI:10.1158/2159-8290.CD-RW2018-210
Hematopoiesis
- Research WatchCancer Discov January 1 2019 9 (1) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2018-208
Immunology
- Research WatchCancer Discov January 1 2019 9 (1) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2018-202
- Research WatchCancer Discov January 1 2019 9 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2018-206
Immunotherapy
- Research WatchCancer Discov January 1 2019 9 (1) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2018-204
- Research WatchCancer Discov January 1 2019 9 (1) 14-14; DOI:10.1158/2159-8290.CD-RW2018-200
- Research WatchCancer Discov January 1 2019 9 (1) 12-12; DOI:10.1158/2159-8290.CD-RW2018-201
Leukemia
- Research WatchCancer Discov January 1 2019 9 (1) 11-11; DOI:10.1158/2159-8290.CD-RW2018-207
Metabolism
- Research WatchCancer Discov January 1 2019 9 (1) 15-15; DOI:10.1158/2159-8290.CD-RW2018-209
Metastasis
- Research WatchCancer Discov January 1 2019 9 (1) 14-14; DOI:10.1158/2159-8290.CD-RW2018-205
Oncogenes
- Research WatchCancer Discov January 1 2019 9 (1) 13-13; DOI:10.1158/2159-8290.CD-RW2018-199
Prostate Cancer
- Research WatchCancer Discov January 1 2019 9 (1) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2018-211
Acknowledgment to Reviewers
- Acknowledgment to ReviewersCancer Discov January 1 2019 9 (1) 148-149; DOI:10.1158/2159-8290.CD-9-1-Reviewers
Volume 9, Issue 1
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