Table of Contents

Research Articles

• Research Articles | AuthorChoice

  Genome-Informed Targeted Therapy for Osteosarcoma

  Leanne C. Sayles, Marcus R. Breese, Amanda L. Koehne, Stanley G. Leung, Alex G. Lee, Heng-Yi Liu, Aviv Spillinger, Avanthi T. Shah, Bogdan Tanasa, Krystal Straessler, Florette K. Hazard, Sheri L. Spunt, Neyssa Marina, Grace E. Kim, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Mi-Ok Kim, Steven G. DuBois, Douglas S. Hawkins and E. Alejandro Sweet-Cordero

  Cancer Discov January 1 2019 9 (1) 46-63; DOI:10.1158/2159-8290.CD-17-1152

  
  

  Genomic characterization and the establishment of patient-derived xenografts identify therapeutic targets within recurrent SCNAs in osteosarcoma subclasses.

• Research Articles

  Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

  Amanpreet Kaur, Brett L. Ecker, Stephen M. Douglass, Curtis H. Kugel III, Marie R. Webster, Filipe V. Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A. Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W. Speicher, Jennifer A. Wargo, Michael T. Tetzlaff, Lauren E. Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman and Ashani T. Weeraratna

  Cancer Discov January 1 2019 9 (1) 64-81; DOI:10.1158/2159-8290.CD-18-0193

  
  

  Loss of the cross-linking protein HAPLN1 in skin fibroblasts during aging results in changes to the extracellular matrix architecture that enhance melanoma cell invasion but impair immune cell infiltration.

• Research Articles

  Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis

  Brett L. Ecker, Amanpreet Kaur, Stephen M. Douglass, Marie R. Webster, Filipe V. Almeida, Gloria E. Marino, Andrew J. Sinnamon, Madalyn G. Neuwirth, Gretchen M. Alicea, Abibatou Ndoye, Mitchell Fane, Xiaowei Xu, Myung Shin Sim, Gary B. Deutsch, Mark B. Faries, Giorgos C. Karakousis and Ashani T. Weeraratna

  Cancer Discov January 1 2019 9 (1) 82-95; DOI:10.1158/2159-8290.CD-18-0168

  
  

  Changes in ECM degradation and lymphatic vasculature permeability during aging are mediated by the cross-linking protein HAPLN1 and determine the route of metastatic dissemination.

• Research Articles | AuthorChoice

  Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

  Xia Liu, Rokana Taftaf, Madoka Kawaguchi, Ya-Fang Chang, Wenjing Chen, David Entenberg, Youbin Zhang, Lorenzo Gerratana, Simo Huang, Dhwani B. Patel, Elizabeth Tsui, Valery Adorno-Cruz, Steven M. Chirieleison, Yue Cao, Allison S. Harney, Shivani Patel, Antonia Patsialou, Yang Shen, Stefanie Avril, Hannah L. Gilmore, Justin D. Lathia, Derek W. Abbott, Massimo Cristofanilli, John S. Condeelis and Huiping Liu

  Cancer Discov January 1 2019 9 (1) 96-113; DOI:10.1158/2159-8290.CD-18-0065

  
  

  Intercellular homophilic CD44 interaction–mediated tumor cell aggregation recruits PAK2 and activates the PAK2 signaling pathway to drive tumorigenesis and polyclonal metastasis.

• Research Articles | AuthorChoice

  Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

  Zhiguo Chen, Juan Mo, Jean-Philippe Brosseau, Tracey Shipman, Yong Wang, Chung-Ping Liao, Jonathan M. Cooper, Robert J. Allaway, Sara J.C. Gosline, Justin Guinney, Thomas J. Carroll and Lu Q. Le

  Cancer Discov January 1 2019 9 (1) 114-129; DOI:10.1158/2159-8290.CD-18-0151

  
  

  Inactivation of Nf1 in a Hoxb7-expressing cell lineage faithfully models neurofi bromagenesis and provides insights into the developmental origin of both plexiform and cutaneous neurofi broma.

• Research Articles

  Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells

  Katarzyna J. Radomska, Fanny Coulpier, Aurelie Gresset, Alain Schmitt, Amal Debbiche, Sophie Lemoine, Pierre Wolkenstein, Jean-Michel Vallat, Patrick Charnay and Piotr Topilko

  Cancer Discov January 1 2019 9 (1) 130-147; DOI:10.1158/2159-8290.CD-18-0156

  
  

  Loss of Nf1 in Prss56-expressing boundary cap cells recapitulates both cutaneous and plexiform neurofi broma and provides insight into neurofi bromagenesis.