Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Precision Medicine and Therapeutic Resistance
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Discovery
Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Precision Medicine and Therapeutic Resistance
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov November 1 2019 9 (11) 1469-1472; DOI:10.1158/2159-8290.CD-ITI9-11

In the Spotlight

  • In the Spotlight
    Dendritic Cells Drive Osteosarcomagenesis through Newly Identified Oncogene and Tumor Suppressor
    Kevin B. Jones
    Cancer Discov November 1 2019 9 (11) 1484-1486; DOI:10.1158/2159-8290.CD-19-0994

  • In the Spotlight
    Immunotransplant: Preventing Unintended Consequences
    Stephen M. Ansell
    Cancer Discov November 1 2019 9 (11) 1487-1489; DOI:10.1158/2159-8290.CD-19-0977

  • In the Spotlight
    Androgen Receptor Interaction with Mediator Complex Is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1
    Joshua W. Russo, Mannan Nouri and Steven P. Balk
    Cancer Discov November 1 2019 9 (11) 1490-1492; DOI:10.1158/2159-8290.CD-19-1028

Review

  • Review
    Altered RNA Processing in Cancer Pathogenesis and Therapy
    Esther A. Obeng, Connor Stewart and Omar Abdel-Wahab
    Cancer Discov November 1 2019 9 (11) 1493-1510; DOI:10.1158/2159-8290.CD-19-0399

Research Brief

  • Research Brief | AuthorChoice
    Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
    Maya Kansara, Kristian Thomson, Puiyi Pang, Aurelie Dutour, Lisa Mirabello, Francine Acher, Jean-Philippe Pin, Elizabeth G. Demicco, Juming Yan, Michele W.L. Teng, Mark J. Smyth and David M. Thomas
    Cancer Discov November 1 2019 9 (11) 1511-1519; DOI:10.1158/2159-8290.CD-19-0154

    Glutamate metabotropic receptor 4 regulates the expression of the inflammatory cytokine IL23 in mice, leading to a restriction of osteosarcoma development that can be therapeutically targeted.

Research Articles

  • Research Articles
    Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
    Netonia Marshall, Keino Hutchinson, Thomas U. Marron, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Judit Svensson-Arvelund, Brian D. Brown, Miriam Merad and Joshua D. Brody
    Cancer Discov November 1 2019 9 (11) 1520-1537; DOI:10.1158/2159-8290.CD-19-0391

    Combination treatment with PD-1 and CLTA4 inhibitors both before and after bone-marrow transplant into lymphodepleted recipient mice increased antitumor efficacy over immune-checkpoint blockade or bone-marrow transplant alone in a γc-dependent manner.

  • Research Articles
    CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation
    Reyaz ur Rasool, Ramakrishnan Natesan, Qu Deng, Shweta Aras, Priti Lal, Samuel Sander Effron, Erick Mitchell-Velasquez, Jessica M. Posimo, Shannon Carskadon, Sylvan C. Baca, Mark M. Pomerantz, Javed Siddiqui, Lauren E. Schwartz, Daniel J. Lee, Nallasivam Palanisamy, Goutham Narla, Robert B. Den, Matthew L. Freedman, Donita C. Brady and Irfan A. Asangani
    Cancer Discov November 1 2019 9 (11) 1538-1555; DOI:10.1158/2159-8290.CD-19-0189

    Phosphorylation of MED1 by the cyclin-dependent kinase CDK7 leads to an interaction between MED1 and AR, and CDK7 inhibition causes tumor regression in a mouse model of castration-resistant prostate cancer.

  • Research Articles
    Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
    Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay and Jeremy N. Rich
    Cancer Discov November 1 2019 9 (11) 1556-1573; DOI:10.1158/2159-8290.CD-19-0215

    The core circadian proteins BMAL1 and CLOCK are essential to the maintenance of glioblastoma stem cells, and genetic or pharmacologic inhibition of BMAL1 or CLOCK increased survival in a mouse model of glioblastoma.

  • Research Articles
    ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells
    Ana Jimenez-Pascual, James S. Hale, Anja Kordowski, Jamie Pugh, Daniel J. Silver, Defne Bayik, Gustavo Roversi, Tyler J. Alban, Shilpa Rao, Rui Chen, Thomas M. McIntyre, Giorgio Colombo, Giulia Taraboletti, Karl O. Holmberg, Karin Forsberg-Nilsson, Justin D. Lathia and Florian A. Siebzehnrubl
    Cancer Discov November 1 2019 9 (11) 1574-1589; DOI:10.1158/2159-8290.CD-18-1308

    A positive feedback loop involving the disintegrin metalloproteinase ADAMDEC1 maintains the stemness of recurrence-driving glioblastoma stem cells.

  • Research Articles
    An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
    Christopher W. Murray, Jennifer J. Brady, Min K. Tsai, Chuan Li, Ian P. Winters, Rui Tang, Laura Andrejka, Rosanna K. Ma, Christian A. Kunder, Pauline Chu and Monte M. Winslow
    Cancer Discov November 1 2019 9 (11) 1590-1605; DOI:10.1158/2159-8290.CD-18-1237

    An in vivo CRISPR screen of LKB1 targets identified SIK1 and SIK3 as mediators of the tumor-suppressive effects of LKB1 in the lung.

  • Research Articles
    The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC
    Pablo E. Hollstein, Lillian J. Eichner, Sonja N. Brun, Anwesh Kamireddy, Robert U. Svensson, Liliana I. Vera, Debbie S. Ross, T.J. Rymoff, Amanda Hutchins, Hector M. Galvez, April E. Williams, Maxim N. Shokhirev, Robert A. Screaton, Rebecca Berdeaux and Reuben J. Shaw
    Cancer Discov November 1 2019 9 (11) 1606-1627; DOI:10.1158/2159-8290.CD-18-1261

    Lack of activation of the AMPK-related kinases SIK1 and SIK3 may be responsible for the tumorigenic effect of LKB1 mutations in non–small cell lung cancer.

News in Brief

  • News in Brief
    People
    Cancer Discov November 1 2019 9 (11) 1474-1474; DOI:10.1158/2159-8290.CD-NB2019-107

  • News in Brief
    Drug Targets Don't Pass Muster with CRISPR
    Cancer Discov November 1 2019 9 (11) 1474-1474; DOI:10.1158/2159-8290.CD-NB2019-111

  • News in Brief
    Database Drives Biomarker Research
    Cancer Discov November 1 2019 9 (11) 1474-1475; DOI:10.1158/2159-8290.CD-NB2019-114

  • News in Brief
    Collaborative Review, Concurrent Approval
    Cancer Discov November 1 2019 9 (11) 1475-1476; DOI:10.1158/2159-8290.CD-NB2019-113

  • News in Brief
    Brain Tumors Feed off Healthy Neurons
    Cancer Discov November 1 2019 9 (11) 1476-1476; DOI:10.1158/2159-8290.CD-NB2019-117

  • News in Brief
    First RET Inhibitor on Path to FDA Approval
    Cancer Discov November 1 2019 9 (11) 1476-1477; DOI:10.1158/2159-8290.CD-NB2019-112

  • News in Brief
    By the Numbers: Percent Share of Novel FDA Drug Approvals in Four Major Therapeutic Categories, 1980–2018
    Cancer Discov November 1 2019 9 (11) 1477-1477; DOI:10.1158/2159-8290.CD-NB2019-119

  • News in Brief
    Noted
    Cancer Discov November 1 2019 9 (11) 1477-1477; DOI:10.1158/2159-8290.CD-NB2019-106

  • News in Brief
    FDA Offers Advice on Trial Design
    Cancer Discov November 1 2019 9 (11) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2019-115

  • News in Brief
    FDA Addresses Breast Cancer in Men
    Cancer Discov November 1 2019 9 (11) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2019-110

  • News in Brief
    Pyrotinib Tops Lapatinib in Metastatic Breast Cancer
    Cancer Discov November 1 2019 9 (11) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2019-109

  • News in Brief
    USPSTF Calls for More BRCA Screening
    Cancer Discov November 1 2019 9 (11) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2019-105

News in Depth

  • News in Depth
    Immune System Research Underlies Lasker Awards
    Cancer Discov November 1 2019 9 (11) 1478-1478; DOI:10.1158/2159-8290.CD-ND2019-011

Research Watch

  • Clinical Trials

    • Research Watch
      Pegilodecakin Plus Anti–PD-1 Is Tolerable and Effective
      Cancer Discov November 1 2019 9 (11) 1482-1482; DOI:10.1158/2159-8290.CD-RW2019-152

  • Epigenetics

    • Research Watch
      Cancer-Associated DNMT3A Is Recruited by H3K36me2 to Methylate DNA
      Cancer Discov November 1 2019 9 (11) 1482-1482; DOI:10.1158/2159-8290.CD-RW2019-142

  • Immunology

    • Research Watch
      PTPN2 Mediates Production of Exhausted T Cells and Antitumor Immunity
      Cancer Discov November 1 2019 9 (11) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2019-151

  • Immunotherapy

    • Research Watch
      γ-Secretase Inhibitors Improve Multiple Myeloma BCMA CAR-T Therapy
      Cancer Discov November 1 2019 9 (11) 1483-1483; DOI:10.1158/2159-8290.CD-RW2019-153

    • Research Watch
      HSC-iNKT Cell Therapy May Be a Feasible Therapeutic Strategy
      Cancer Discov November 1 2019 9 (11) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2019-143

  • Leukemia

    • Research Watch
      Asciminib with Ponatinib Lowers Resistance in Chronic Myeloid Leukemia
      Cancer Discov November 1 2019 9 (11) 1481-1481; DOI:10.1158/2159-8290.CD-RW2019-149

    • Research Watch
      MLLs Bind Differently to Nucleosomes with Ubiquitinated Histone H2B
      Cancer Discov November 1 2019 9 (11) 1481-1481; DOI:10.1158/2159-8290.CD-RW2019-141

  • Liquid Biopsy

    • Research Watch
      Comparison of cfDNA and Tissue Biopsy Shows Heterogeneity in Resistance
      Cancer Discov November 1 2019 9 (11) 1479-1479; DOI:10.1158/2159-8290.CD-RW2019-147

  • Lymphoma

    • Research Watch
      Lymphoma Cells Are Retained in Gliotic Nervous-System Tissue
      Cancer Discov November 1 2019 9 (11) 1479-1479; DOI:10.1158/2159-8290.CD-RW2019-146

  • Melanoma

    • Research Watch
      Low-Heterogeneity Melanomas Are More Immunogenic and Less Aggressive
      Cancer Discov November 1 2019 9 (11) 1483-1483; DOI:10.1158/2159-8290.CD-RW2019-144

  • Pancreatic Cancer

    • Research Watch
      Pancreatic Cancer Cell Fate Is Mediated by a p53–α-Ketoglutarate Link
      Cancer Discov November 1 2019 9 (11) 1480-1480; DOI:10.1158/2159-8290.CD-RW2019-148

  • Signaling

    • Research Watch
      SLC19A1 Transports STING-Stimulating Cyclic Dinucleotides into Cells
      Cancer Discov November 1 2019 9 (11) 1480-1480; DOI:10.1158/2159-8290.CD-RW2019-145

  • Structural Biology

    • Research Watch
      The Structure of an Active BRAF Dimer Shows Active-Site Asymmetry
      Cancer Discov November 1 2019 9 (11) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2019-150

  • Corrections

    • Corrections | Free Article
      Correction: NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
      Cancer Discov November 1 2019 9 (11) 1628-1628; DOI:10.1158/2159-8290.CD-19-1108

    • Corrections | Free Article
      Correction: Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma
      Cancer Discov November 1 2019 9 (11) 1629-1629; DOI:10.1158/2159-8290.CD-19-1135

Back to top
PreviousNext
Cancer Discovery: 9 (11)
November 2019
Volume 9, Issue 11
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

Jump to

  • In This Issue
  • In the Spotlight
  • Review
  • Research Brief
  • Research Articles
  • News in Brief
  • News in Depth
  • Research Watch
    • Clinical Trials
    • Epigenetics
    • Immunology
    • Immunotherapy
    • Leukemia
    • Liquid Biopsy
    • Lymphoma
    • Melanoma
    • Pancreatic Cancer
    • Signaling
    • Structural Biology
    • Corrections
Advertisement
  • Most Cited
  • Most Read
Loading
  • The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
  • Macrophages Regulate Response to Chemotherapy
  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • Novel Mutant-Selective EGFR Inhibitor Overcomes Drug Resistance
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
More...
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • OnlineFirst
  • Current Issue
  • Past Issues

Info For

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Discovery

  • About the Journal
  • Editors
  • Journal Sections
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

Advertisement