Table of Contents

Research Articles

• Research Articles

  Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade

  Netonia Marshall, Keino Hutchinson, Thomas U. Marron, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Judit Svensson-Arvelund, Brian D. Brown, Miriam Merad and Joshua D. Brody

  Cancer Discov November 1 2019 9 (11) 1520-1537; DOI:10.1158/2159-8290.CD-19-0391

  
  

  Combination treatment with PD-1 and CLTA4 inhibitors both before and after bone-marrow transplant into lymphodepleted recipient mice increased antitumor efficacy over immune-checkpoint blockade or bone-marrow transplant alone in a γ_c-dependent manner.

• Research Articles

  CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation

  Reyaz ur Rasool, Ramakrishnan Natesan, Qu Deng, Shweta Aras, Priti Lal, Samuel Sander Effron, Erick Mitchell-Velasquez, Jessica M. Posimo, Shannon Carskadon, Sylvan C. Baca, Mark M. Pomerantz, Javed Siddiqui, Lauren E. Schwartz, Daniel J. Lee, Nallasivam Palanisamy, Goutham Narla, Robert B. Den, Matthew L. Freedman, Donita C. Brady and Irfan A. Asangani

  Cancer Discov November 1 2019 9 (11) 1538-1555; DOI:10.1158/2159-8290.CD-19-0189

  
  

  Phosphorylation of MED1 by the cyclin-dependent kinase CDK7 leads to an interaction between MED1 and AR, and CDK7 inhibition causes tumor regression in a mouse model of castration-resistant prostate cancer.

• Research Articles

  Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

  Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay and Jeremy N. Rich

  Cancer Discov November 1 2019 9 (11) 1556-1573; DOI:10.1158/2159-8290.CD-19-0215

  
  

  The core circadian proteins BMAL1 and CLOCK are essential to the maintenance of glioblastoma stem cells, and genetic or pharmacologic inhibition of BMAL1 or CLOCK increased survival in a mouse model of glioblastoma.

• Research Articles

  ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

  Ana Jimenez-Pascual, James S. Hale, Anja Kordowski, Jamie Pugh, Daniel J. Silver, Defne Bayik, Gustavo Roversi, Tyler J. Alban, Shilpa Rao, Rui Chen, Thomas M. McIntyre, Giorgio Colombo, Giulia Taraboletti, Karl O. Holmberg, Karin Forsberg-Nilsson, Justin D. Lathia and Florian A. Siebzehnrubl

  Cancer Discov November 1 2019 9 (11) 1574-1589; DOI:10.1158/2159-8290.CD-18-1308

  
  

  A positive feedback loop involving the disintegrin metalloproteinase ADAMDEC1 maintains the stemness of recurrence-driving glioblastoma stem cells.

• Research Articles

  An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation

  Christopher W. Murray, Jennifer J. Brady, Min K. Tsai, Chuan Li, Ian P. Winters, Rui Tang, Laura Andrejka, Rosanna K. Ma, Christian A. Kunder, Pauline Chu and Monte M. Winslow

  Cancer Discov November 1 2019 9 (11) 1590-1605; DOI:10.1158/2159-8290.CD-18-1237

  
  

  An in vivo CRISPR screen of LKB1 targets identified SIK1 and SIK3 as mediators of the tumor-suppressive effects of LKB1 in the lung.

• Research Articles

  The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC

  Pablo E. Hollstein, Lillian J. Eichner, Sonja N. Brun, Anwesh Kamireddy, Robert U. Svensson, Liliana I. Vera, Debbie S. Ross, T.J. Rymoff, Amanda Hutchins, Hector M. Galvez, April E. Williams, Maxim N. Shokhirev, Robert A. Screaton, Rebecca Berdeaux and Reuben J. Shaw

  Cancer Discov November 1 2019 9 (11) 1606-1627; DOI:10.1158/2159-8290.CD-18-1261

  
  

  Lack of activation of the AMPK-related kinases SIK1 and SIK3 may be responsible for the tumorigenic effect of LKB1 mutations in non–small cell lung cancer.