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Cancer Discovery
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Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade

Netonia Marshall, Keino Hutchinson, Thomas U. Marron, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Judit Svensson-Arvelund, Brian D. Brown, Miriam Merad and Joshua D. Brody
Netonia Marshall
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Keino Hutchinson
2Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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  • ORCID record for Keino Hutchinson
Thomas U. Marron
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Mark Aleynick
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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  • ORCID record for Mark Aleynick
Linda Hammerich
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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  • ORCID record for Linda Hammerich
Ranjan Upadhyay
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Judit Svensson-Arvelund
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Brian D. Brown
3Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Miriam Merad
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
4Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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Joshua D. Brody
1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
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  • For correspondence: Joshua.Brody@mssm.edu
DOI: 10.1158/2159-8290.CD-19-0391 Published November 2019
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Total61268671262

Cited By

Article Information

Volume 9, Issue 11, pp. 1520-1537

DOI 
https://doi.org/10.1158/2159-8290.CD-19-0391
PubMed 
31375522

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received April 3, 2019
  • Revision received June 18, 2019
  • Accepted July 16, 2019
  • Published first August 2, 2019.

Article Versions

  • Previous version (August 2, 2019 - 00:05).
  • Previous version (October 14, 2019 - 05:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Netonia Marshall1,
  2. Keino Hutchinson2,
  3. Thomas U. Marron1,
  4. Mark Aleynick1,
  5. Linda Hammerich1,
  6. Ranjan Upadhyay1,
  7. Judit Svensson-Arvelund1,
  8. Brian D. Brown3,
  9. Miriam Merad1,4 and
  10. Joshua D. Brody1,*
  1. 1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
  2. 2Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
  3. 3Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
  4. 4Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.
  1. ↵*Corresponding Author:
    Joshua D. Brody, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029. Phone: 212-241-5426; E-mail: Joshua.Brody{at}mssm.edu
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Cancer Discovery: 9 (11)
November 2019
Volume 9, Issue 11
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Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Netonia Marshall, Keino Hutchinson, Thomas U. Marron, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Judit Svensson-Arvelund, Brian D. Brown, Miriam Merad and Joshua D. Brody
Cancer Discov November 1 2019 (9) (11) 1520-1537; DOI: 10.1158/2159-8290.CD-19-0391

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Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Netonia Marshall, Keino Hutchinson, Thomas U. Marron, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Judit Svensson-Arvelund, Brian D. Brown, Miriam Merad and Joshua D. Brody
Cancer Discov November 1 2019 (9) (11) 1520-1537; DOI: 10.1158/2159-8290.CD-19-0391
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