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Cancer Discovery
Cancer Discovery
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About the Cover

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In a first-in-human, phase I clinical trial, Kim and colleagues investigated the use of the fibroblast growth factor receptor 4 (FGFR4) inhibitor fisogatinib in patients with hepatocellular carcinoma, demonstrating that it is generally tolerable and may be of clinical utility in patients positive for fibroblast growth factor 19 By investigating mechanisms of resistance to fisogatinib in select patients in the trial as well as by conducting further in vitro and in vivo studies, Hatlen, Schmidt-Kittler, and colleagues found evidence that FGFR4 is, as has been suspected but never proven, a driver of hepatocellular carcinoma For details, please see the article by Kim and colleagues on page 1696 and the article by Hatlen, Schmidt-Kittler, and colleagues on page 1686.

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Cancer Discovery: 9 (12)
December 2019
Volume 9, Issue 12
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Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

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