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A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer

Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman
Sheau W. Lok
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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James R. Whittle
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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François Vaillant
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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  • ORCID record for François Vaillant
Charis E. Teh
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Louisa L. Lo
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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  • ORCID record for Louisa L. Lo
Antonia N. Policheni
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Alice R.T. Bergin
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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  • ORCID record for Alice R.T. Bergin
Jayesh Desai
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Sarah Ftouni
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Luke C. Gandolfo
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Danny Liew
4The University of Melbourne, Melbourne, Victoria, Australia.
5School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
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He K. Liu
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
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G. Bruce Mann
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
6The Royal Women's Hospital, Melbourne, Victoria, Australia.
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Kate Moodie
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Anand Murugasu
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
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Bhupinder Pal
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
7Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
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Andrew W. Roberts
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Mark A. Rosenthal
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Kylie Shackleton
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
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Maria João Silva
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Zhen R. Siow
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Gordon K. Smyth
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Leanne Taylor
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
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Avraham Travers
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Belinda Yeo
7Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
8Austin Health, Melbourne, Victoria, Australia.
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Miriam M. Yeung
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Andjelija Zivanovic Bujak
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Sarah-Jane Dawson
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Daniel H.D. Gray
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Jane E. Visvader
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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Geoffrey J. Lindeman
1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4The University of Melbourne, Melbourne, Victoria, Australia.
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  • ORCID record for Geoffrey J. Lindeman
  • For correspondence: lindeman@wehi.edu.au
DOI: 10.1158/2159-8290.CD-18-1151 Published March 2019
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Article Information

Volume 9, Issue 3, pp. 354-369

DOI 
https://doi.org/10.1158/2159-8290.CD-18-1151
PubMed 
30518523

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received September 29, 2018
  • Revision received October 24, 2018
  • Accepted November 2, 2018
  • Published first December 5, 2018.

Article Versions

  • Previous version (December 5, 2018 - 14:30).
  • Previous version (February 7, 2019 - 05:48).
  • Previous version (February 15, 2019 - 06:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Sheau W. Lok1,2,3,
  2. James R. Whittle1,2,3,4,
  3. François Vaillant2,4,
  4. Charis E. Teh2,4,
  5. Louisa L. Lo3,4,
  6. Antonia N. Policheni2,4,
  7. Alice R.T. Bergin1,2,3,
  8. Jayesh Desai1,2,3,
  9. Sarah Ftouni3,
  10. Luke C. Gandolfo2,4,
  11. Danny Liew4,5,
  12. He K. Liu2,
  13. G. Bruce Mann1,3,4,6,
  14. Kate Moodie3,
  15. Anand Murugasu1,
  16. Bhupinder Pal2,4,7,
  17. Andrew W. Roberts1,2,4,
  18. Mark A. Rosenthal1,3,4,
  19. Kylie Shackleton1,2,
  20. Maria João Silva3,
  21. Zhen R. Siow1,2,3,
  22. Gordon K. Smyth2,4,
  23. Leanne Taylor1,
  24. Avraham Travers1,2,3,
  25. Belinda Yeo7,8,
  26. Miriam M. Yeung3,
  27. Andjelija Zivanovic Bujak3,4,
  28. Sarah-Jane Dawson3,4,
  29. Daniel H.D. Gray2,4,
  30. Jane E. Visvader2,4 and
  31. Geoffrey J. Lindeman1,2,3,4,*
  1. 1The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  2. 2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
  3. 3The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  4. 4The University of Melbourne, Melbourne, Victoria, Australia.
  5. 5School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  6. 6The Royal Women's Hospital, Melbourne, Victoria, Australia.
  7. 7Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
  8. 8Austin Health, Melbourne, Victoria, Australia.
  1. ↵*Corresponding Author:
    Geoffrey J. Lindeman, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia. Phone: 61-3-9345-2611; Fax: 61-3-9347-0852; E-mail: lindeman{at}wehi.edu.au
  1. S.W. Lok and J.R. Whittle contributed equally to this article.

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Cancer Discovery: 9 (3)
March 2019
Volume 9, Issue 3
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A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer
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A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer
Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman
Cancer Discov March 1 2019 (9) (3) 354-369; DOI: 10.1158/2159-8290.CD-18-1151

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A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer
Sheau W. Lok, James R. Whittle, François Vaillant, Charis E. Teh, Louisa L. Lo, Antonia N. Policheni, Alice R.T. Bergin, Jayesh Desai, Sarah Ftouni, Luke C. Gandolfo, Danny Liew, He K. Liu, G. Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W. Roberts, Mark A. Rosenthal, Kylie Shackleton, Maria João Silva, Zhen R. Siow, Gordon K. Smyth, Leanne Taylor, Avraham Travers, Belinda Yeo, Miriam M. Yeung, Andjelija Zivanovic Bujak, Sarah-Jane Dawson, Daniel H.D. Gray, Jane E. Visvader and Geoffrey J. Lindeman
Cancer Discov March 1 2019 (9) (3) 354-369; DOI: 10.1158/2159-8290.CD-18-1151
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