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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2019 9 (5) 565-567; DOI:10.1158/2159-8290.CD-ITI9-5

In the Spotlight

  • In the Spotlight
    A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth
    Giulia Biffi and David A. Tuveson
    Cancer Discov May 1 2019 9 (5) 578-580; DOI:10.1158/2159-8290.CD-19-0273

  • In the Spotlight
    Metabolic Checkpoint of Immune Cells in Melanoma Brain Metastases
    Colt A. Egelston and Kim Margolin
    Cancer Discov May 1 2019 9 (5) 581-583; DOI:10.1158/2159-8290.CD-19-0249

  • In the Spotlight
    Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways
    Joseph B. Hiatt and David MacPherson
    Cancer Discov May 1 2019 9 (5) 584-586; DOI:10.1158/2159-8290.CD-19-0234

Review

  • Review
    Engineering Multidimensional Evolutionary Forces to Combat Cancer
    Caroline E. McCoach and Trever G. Bivona
    Cancer Discov May 1 2019 9 (5) 587-604; DOI:10.1158/2159-8290.CD-18-1196

Research Briefs

  • Research Briefs
    Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer
    Emily K. Slotkin, Daniel Diolaiti, Neerav N. Shukla, Filemon S. Dela Cruz, Jennifer J. Clark, Gunes Gundem, Venkata D. Yellapantula, Max F. Levine, Daoqi You, Peilin Ma, Sagarika Pachhal, Glorymar Ibanez Sanchez, Ryma Benayed, Achim A. Jungbluth, Lillian M. Smyth, Audrey Mauguen, Irena Gushterova, Hongxu Ding, Lee Spraggon, Robert Darnell, Andrea Califano, Marc Ladanyi, Elli Papaemmanuil, Andrew L. Kung, David M. Hyman and Stephen S. Roberts
    Cancer Discov May 1 2019 9 (5) 605-616; DOI:10.1158/2159-8290.CD-18-0953

    The response to AKT inhibition in a pediatric patient with a LAMTOR1–AKT1 fusion confirms the AKT1 fusion as an oncogenic driver, and subsequent characterization of the fusion suggests potential ways to overcome resistance.

  • Research Briefs | AuthorChoice
    A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
    Francesca R. Auciello, Vinay Bulusu, Chet Oon, Jacqueline Tait-Mulder, Mark Berry, Sohinee Bhattacharyya, Sergey Tumanov, Brittany L. Allen-Petersen, Jason Link, Nicholas D. Kendsersky, Esmee Vringer, Michelle Schug, David Novo, Rosa F. Hwang, Ronald M. Evans, Colin Nixon, Craig Dorrell, Jennifer P. Morton, Jim C. Norman, Rosalie C. Sears, Jurre J. Kamphorst and Mara H. Sherman
    Cancer Discov May 1 2019 9 (5) 617-627; DOI:10.1158/2159-8290.CD-18-1212

    Lysophosphatidylcholines secreted by activated stromal fibroblasts support pancreatic cancer cell proliferation and migration via autotaxin-mediated production of lysophosphatidic acid.

Research Articles

  • Research Articles | AuthorChoice
    Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
    Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff and Michael A. Davies
    Cancer Discov May 1 2019 9 (5) 628-645; DOI:10.1158/2159-8290.CD-18-1489

    Comprehensive molecular profiling of patient-matched melanoma brain metastases and extracranial metastases unveil significant differences between these two metastatic populations.

  • Research Articles
    Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
    Triparna Sen, B. Leticia Rodriguez, Limo Chen, Carminia M. Della Corte, Naoto Morikawa, Junya Fujimoto, Sandra Cristea, Thuyen Nguyen, Lixia Diao, Lerong Li, Youhong Fan, Yongbin Yang, Jing Wang, Bonnie S. Glisson, Ignacio I. Wistuba, Julien Sage, John V. Heymach, Don L. Gibbons and Lauren A. Byers
    Cancer Discov May 1 2019 9 (5) 646-661; DOI:10.1158/2159-8290.CD-18-1020

    Pharmacologic inhibition of PARP and CHK1 increases expression of PD-L1 and potentiates the antitumor effects of PD-L1 blockade via activation of the innate immune STING pathway.

  • Research Articles
    BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress
    Tharu M. Fernando, Rossella Marullo, Benet Pera Gresely, Jude M. Phillip, Shao Ning Yang, Geoffrey Lundell-Smith, Ingrid Torregroza, Haelee Ahn, Todd Evans, Balázs Győrffy, Gilbert G. Privé, Masayuki Hirano, Ari M. Melnick and Leandro Cerchietti
    Cancer Discov May 1 2019 9 (5) 662-679; DOI:10.1158/2159-8290.CD-17-1444

    An evolutionarily conserved HSF1–BCL6 axis mediates stress adaptation across vertebrates and promotes tolerance to chemotherapy in cancer cells, in part via repression of the transcription factor TOX.

News in Brief

  • News in Brief
    People
    Cancer Discov May 1 2019 9 (5) 568-568; DOI:10.1158/2159-8290.CD-NB2019-032

  • News in Brief
    NCI Paylines Drop as Grant Applications Climb
    Cancer Discov May 1 2019 9 (5) 568-568; DOI:10.1158/2159-8290.CD-NB2019-041

  • News in Brief
    First-Line Atezolizumab OK'd for SCLC
    Cancer Discov May 1 2019 9 (5) 568-569; DOI:10.1158/2159-8290.CD-NB2019-042

  • News in Brief
    Anti–PD-1–CTLA4 Combo Hits Prostate Cancer
    Cancer Discov May 1 2019 9 (5) 569-570; DOI:10.1158/2159-8290.CD-NB2019-039

  • News in Brief
    ADC Could Benefit Some with Breast Cancer
    Cancer Discov May 1 2019 9 (5) 570-570; DOI:10.1158/2159-8290.CD-NB2019-034

  • News in Brief
    Liquid Biopsy Holds Its Own in NSCLC
    Cancer Discov May 1 2019 9 (5) 570-571; DOI:10.1158/2159-8290.CD-NB2019-033

  • News in Brief
    Combo Drug Strategy Tested for PDAC
    Cancer Discov May 1 2019 9 (5) 571-571; DOI:10.1158/2159-8290.CD-NB2019-037

  • News in Brief
    Noted
    Cancer Discov May 1 2019 9 (5) 571-571; DOI:10.1158/2159-8290.CD-NB2019-031

  • News in Brief
    New Agents Designed to Fight EBV+ Cancers
    Cancer Discov May 1 2019 9 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2019-040

  • News in Brief
    Atezolizumab Combo Approved for PD-L1–positive TNBC
    Cancer Discov May 1 2019 9 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2019-038

  • News in Brief
    Eyeing Enzalutamide for Hormone-Sensitive Prostate Cancer
    Cancer Discov May 1 2019 9 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2019-035

  • News in Brief
    Bacterial Mix Enhances Immunotherapy Response
    Cancer Discov May 1 2019 9 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2019-020

News in Depth

  • News in Depth
    Targeting MCL1, Companies Aim to Unblock Apoptosis
    Cancer Discov May 1 2019 9 (5) 572-572; DOI:10.1158/2159-8290.CD-ND2019-002

Research Watch

  • Clinical Trials

    • Research Watch
      Venetoclax–Obinutuzumab Elicits High Response Rates in CLL
      Cancer Discov May 1 2019 9 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2019-039

    • Research Watch
      Parsaclisib Has Activity in Patients with B-cell Malignancies
      Cancer Discov May 1 2019 9 (5) 575-575; DOI:10.1158/2159-8290.CD-RW2019-031

  • Epigenetics

    • Research Watch
      An ATPase Module Guides Mammalian SWI/SNF Complex Specificity
      Cancer Discov May 1 2019 9 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2019-040

  • Genome Stability

    • Research Watch
      Recombination By-products Contribute to RAG-Mediated Chromosomal Alterations
      Cancer Discov May 1 2019 9 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2019-045

  • Immunotherapy

    • Research Watch
      Inhibition of QPCTL Induces Myeloid Immune Checkpoint Blockade
      Cancer Discov May 1 2019 9 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2019-036

    • Research Watch
      Engineered T Cells Bypass Death Signaling and Bolster Immunotherapy
      Cancer Discov May 1 2019 9 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2019-033

  • Melanoma

    • Research Watch
      Potentially Actionable MAP3K8 Alterations Are Common in Spitzoid Melanoma
      Cancer Discov May 1 2019 9 (5) 574-574; DOI:10.1158/2159-8290.CD-RW2019-037

  • Metabolism

    • Research Watch
      NAD Kinase Is an AKT Substrate
      Cancer Discov May 1 2019 9 (5) 576-576; DOI:10.1158/2159-8290.CD-RW2019-038

    • Research Watch
      Macrophage-Derived Nucleosides Reduce the Efficacy of Gemcitabine
      Cancer Discov May 1 2019 9 (5) 574-574; DOI:10.1158/2159-8290.CD-RW2019-032

  • Metastasis

    • Research Watch
      Glucocorticoid Receptor Activity Promotes Breast Cancer Metastasis
      Cancer Discov May 1 2019 9 (5) 577-577; DOI:10.1158/2159-8290.CD-RW2019-041

    • Research Watch
      Hepatocyte Signaling Mediates a Prometastatic Niche in the Liver
      Cancer Discov May 1 2019 9 (5) 573-573; DOI:10.1158/2159-8290.CD-RW2019-035

    • Research Watch
      Pyruvate Mediates ECM Remodeling in the Lung Metastatic Niche
      Cancer Discov May 1 2019 9 (5) 575-575; DOI:10.1158/2159-8290.CD-RW2019-034

  • Mutations

    • Research Watch
      Oncogenic Mutations in RIT1 Ablate LZTR1-mediated Proteolysis
      Cancer Discov May 1 2019 9 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2019-042

  • Oncogenes

    • Research Watch
      KRASG12D Promotes Immunosuppression in Colorectal Cancer
      Cancer Discov May 1 2019 9 (5) 573-573; DOI:10.1158/2159-8290.CD-RW2019-043

  • Prostate Cancer

    • Research Watch
      Delta-like Protein 3 Is a Target in Neuroendocrine Prostate Cancer
      Cancer Discov May 1 2019 9 (5) 577-577; DOI:10.1158/2159-8290.CD-RW2019-047

  • Stem Cells

    • Research Watch
      CXCL12 Has Niche-Specific Roles in Leukemia Stem Cell Function
      Cancer Discov May 1 2019 9 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2019-044

  • Transcription

    • Research Watch
      MYCN Recruits BRCA1 to Limit Accumulation of Stalled RNA Polymerase
      Cancer Discov May 1 2019 9 (5) 576-576; DOI:10.1158/2159-8290.CD-RW2019-046

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Cancer Discovery: 9 (5)
May 2019
Volume 9, Issue 5
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