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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2019 9 (5) 565-567; DOI:10.1158/2159-8290.CD-ITI9-5

In the Spotlight

Review

Research Briefs

  • Research Briefs
    Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer
    Emily K. Slotkin, Daniel Diolaiti, Neerav N. Shukla, Filemon S. Dela Cruz, Jennifer J. Clark, Gunes Gundem, Venkata D. Yellapantula, Max F. Levine, Daoqi You, Peilin Ma, Sagarika Pachhal, Glorymar Ibanez Sanchez, Ryma Benayed, Achim A. Jungbluth, Lillian M. Smyth, Audrey Mauguen, Irena Gushterova, Hongxu Ding, Lee Spraggon, Robert Darnell, Andrea Califano, Marc Ladanyi, Elli Papaemmanuil, Andrew L. Kung, David M. Hyman and Stephen S. Roberts
    Cancer Discov May 1 2019 9 (5) 605-616; DOI:10.1158/2159-8290.CD-18-0953

    The response to AKT inhibition in a pediatric patient with a LAMTOR1–AKT1 fusion confirms the AKT1 fusion as an oncogenic driver, and subsequent characterization of the fusion suggests potential ways to overcome resistance.

  • Research Briefs | AuthorChoice
    A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
    Francesca R. Auciello, Vinay Bulusu, Chet Oon, Jacqueline Tait-Mulder, Mark Berry, Sohinee Bhattacharyya, Sergey Tumanov, Brittany L. Allen-Petersen, Jason Link, Nicholas D. Kendsersky, Esmee Vringer, Michelle Schug, David Novo, Rosa F. Hwang, Ronald M. Evans, Colin Nixon, Craig Dorrell, Jennifer P. Morton, Jim C. Norman, Rosalie C. Sears, Jurre J. Kamphorst and Mara H. Sherman
    Cancer Discov May 1 2019 9 (5) 617-627; DOI:10.1158/2159-8290.CD-18-1212

    Lysophosphatidylcholines secreted by activated stromal fibroblasts support pancreatic cancer cell proliferation and migration via autotaxin-mediated production of lysophosphatidic acid.

Research Articles

  • Research Articles | AuthorChoice
    Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
    Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff and Michael A. Davies
    Cancer Discov May 1 2019 9 (5) 628-645; DOI:10.1158/2159-8290.CD-18-1489

    Comprehensive molecular profiling of patient-matched melanoma brain metastases and extracranial metastases unveil significant differences between these two metastatic populations.

  • Research Articles
    Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
    Triparna Sen, B. Leticia Rodriguez, Limo Chen, Carminia M. Della Corte, Naoto Morikawa, Junya Fujimoto, Sandra Cristea, Thuyen Nguyen, Lixia Diao, Lerong Li, Youhong Fan, Yongbin Yang, Jing Wang, Bonnie S. Glisson, Ignacio I. Wistuba, Julien Sage, John V. Heymach, Don L. Gibbons and Lauren A. Byers
    Cancer Discov May 1 2019 9 (5) 646-661; DOI:10.1158/2159-8290.CD-18-1020

    Pharmacologic inhibition of PARP and CHK1 increases expression of PD-L1 and potentiates the antitumor effects of PD-L1 blockade via activation of the innate immune STING pathway.

  • Research Articles
    BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress
    Tharu M. Fernando, Rossella Marullo, Benet Pera Gresely, Jude M. Phillip, Shao Ning Yang, Geoffrey Lundell-Smith, Ingrid Torregroza, Haelee Ahn, Todd Evans, Balázs Győrffy, Gilbert G. Privé, Masayuki Hirano, Ari M. Melnick and Leandro Cerchietti
    Cancer Discov May 1 2019 9 (5) 662-679; DOI:10.1158/2159-8290.CD-17-1444

    An evolutionarily conserved HSF1–BCL6 axis mediates stress adaptation across vertebrates and promotes tolerance to chemotherapy in cancer cells, in part via repression of the transcription factor TOX.

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