Table of Contents
In This Issue
In the Spotlight
- In the SpotlightGiulia Biffi and David A. TuvesonCancer Discov May 1 2019 9 (5) 578-580; DOI:10.1158/2159-8290.CD-19-0273
- In the SpotlightColt A. Egelston and Kim MargolinCancer Discov May 1 2019 9 (5) 581-583; DOI:10.1158/2159-8290.CD-19-0249
- In the SpotlightJoseph B. Hiatt and David MacPhersonCancer Discov May 1 2019 9 (5) 584-586; DOI:10.1158/2159-8290.CD-19-0234
Review
- ReviewCaroline E. McCoach and Trever G. BivonaCancer Discov May 1 2019 9 (5) 587-604; DOI:10.1158/2159-8290.CD-18-1196
Research Briefs
- Research BriefsEmily K. Slotkin, Daniel Diolaiti, Neerav N. Shukla, Filemon S. Dela Cruz, Jennifer J. Clark, Gunes Gundem, Venkata D. Yellapantula, Max F. Levine, Daoqi You, Peilin Ma, Sagarika Pachhal, Glorymar Ibanez Sanchez, Ryma Benayed, Achim A. Jungbluth, Lillian M. Smyth, Audrey Mauguen, Irena Gushterova, Hongxu Ding, Lee Spraggon, Robert Darnell, Andrea Califano, Marc Ladanyi, Elli Papaemmanuil, Andrew L. Kung, David M. Hyman and Stephen S. RobertsCancer Discov May 1 2019 9 (5) 605-616; DOI:10.1158/2159-8290.CD-18-0953
The response to AKT inhibition in a pediatric patient with a LAMTOR1–AKT1 fusion confirms the AKT1 fusion as an oncogenic driver, and subsequent characterization of the fusion suggests potential ways to overcome resistance.
- Research Briefs | AuthorChoiceFrancesca R. Auciello, Vinay Bulusu, Chet Oon, Jacqueline Tait-Mulder, Mark Berry, Sohinee Bhattacharyya, Sergey Tumanov, Brittany L. Allen-Petersen, Jason Link, Nicholas D. Kendsersky, Esmee Vringer, Michelle Schug, David Novo, Rosa F. Hwang, Ronald M. Evans, Colin Nixon, Craig Dorrell, Jennifer P. Morton, Jim C. Norman, Rosalie C. Sears, Jurre J. Kamphorst and Mara H. ShermanCancer Discov May 1 2019 9 (5) 617-627; DOI:10.1158/2159-8290.CD-18-1212
Lysophosphatidylcholines secreted by activated stromal fibroblasts support pancreatic cancer cell proliferation and migration via autotaxin-mediated production of lysophosphatidic acid.
Research Articles
- Research Articles | AuthorChoiceGrant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff and Michael A. DaviesCancer Discov May 1 2019 9 (5) 628-645; DOI:10.1158/2159-8290.CD-18-1489
Comprehensive molecular profiling of patient-matched melanoma brain metastases and extracranial metastases unveil significant differences between these two metastatic populations.
- Research ArticlesTriparna Sen, B. Leticia Rodriguez, Limo Chen, Carminia M. Della Corte, Naoto Morikawa, Junya Fujimoto, Sandra Cristea, Thuyen Nguyen, Lixia Diao, Lerong Li, Youhong Fan, Yongbin Yang, Jing Wang, Bonnie S. Glisson, Ignacio I. Wistuba, Julien Sage, John V. Heymach, Don L. Gibbons and Lauren A. ByersCancer Discov May 1 2019 9 (5) 646-661; DOI:10.1158/2159-8290.CD-18-1020
Pharmacologic inhibition of PARP and CHK1 increases expression of PD-L1 and potentiates the antitumor effects of PD-L1 blockade via activation of the innate immune STING pathway.
- Research ArticlesTharu M. Fernando, Rossella Marullo, Benet Pera Gresely, Jude M. Phillip, Shao Ning Yang, Geoffrey Lundell-Smith, Ingrid Torregroza, Haelee Ahn, Todd Evans, Balázs Győrffy, Gilbert G. Privé, Masayuki Hirano, Ari M. Melnick and Leandro CerchiettiCancer Discov May 1 2019 9 (5) 662-679; DOI:10.1158/2159-8290.CD-17-1444
An evolutionarily conserved HSF1–BCL6 axis mediates stress adaptation across vertebrates and promotes tolerance to chemotherapy in cancer cells, in part via repression of the transcription factor TOX.
News in Brief
- News in BriefCancer Discov May 1 2019 9 (5) 568-568; DOI:10.1158/2159-8290.CD-NB2019-041
- News in BriefCancer Discov May 1 2019 9 (5) 568-569; DOI:10.1158/2159-8290.CD-NB2019-042
- News in BriefCancer Discov May 1 2019 9 (5) 569-570; DOI:10.1158/2159-8290.CD-NB2019-039
- News in BriefCancer Discov May 1 2019 9 (5) 570-570; DOI:10.1158/2159-8290.CD-NB2019-034
- News in BriefCancer Discov May 1 2019 9 (5) 570-571; DOI:10.1158/2159-8290.CD-NB2019-033
- News in BriefCancer Discov May 1 2019 9 (5) 571-571; DOI:10.1158/2159-8290.CD-NB2019-037
- News in BriefCancer Discov May 1 2019 9 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2019-040
- News in BriefCancer Discov May 1 2019 9 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2019-038
- News in BriefCancer Discov May 1 2019 9 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2019-035
- News in BriefCancer Discov May 1 2019 9 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2019-020
News in Depth
- News in DepthCancer Discov May 1 2019 9 (5) 572-572; DOI:10.1158/2159-8290.CD-ND2019-002
Research Watch
Clinical Trials
- Research WatchCancer Discov May 1 2019 9 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2019-039
- Research WatchCancer Discov May 1 2019 9 (5) 575-575; DOI:10.1158/2159-8290.CD-RW2019-031
Epigenetics
- Research WatchCancer Discov May 1 2019 9 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2019-040
Genome Stability
- Research WatchCancer Discov May 1 2019 9 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2019-045
Immunotherapy
- Research WatchCancer Discov May 1 2019 9 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2019-036
- Research WatchCancer Discov May 1 2019 9 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2019-033
Melanoma
- Research WatchCancer Discov May 1 2019 9 (5) 574-574; DOI:10.1158/2159-8290.CD-RW2019-037
Metabolism
- Research WatchCancer Discov May 1 2019 9 (5) 576-576; DOI:10.1158/2159-8290.CD-RW2019-038
- Research WatchCancer Discov May 1 2019 9 (5) 574-574; DOI:10.1158/2159-8290.CD-RW2019-032
Metastasis
- Research WatchCancer Discov May 1 2019 9 (5) 577-577; DOI:10.1158/2159-8290.CD-RW2019-041
- Research WatchCancer Discov May 1 2019 9 (5) 573-573; DOI:10.1158/2159-8290.CD-RW2019-035
- Research WatchCancer Discov May 1 2019 9 (5) 575-575; DOI:10.1158/2159-8290.CD-RW2019-034
Mutations
- Research WatchCancer Discov May 1 2019 9 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2019-042
Oncogenes
- Research WatchCancer Discov May 1 2019 9 (5) 573-573; DOI:10.1158/2159-8290.CD-RW2019-043
Prostate Cancer
- Research WatchCancer Discov May 1 2019 9 (5) 577-577; DOI:10.1158/2159-8290.CD-RW2019-047
Stem Cells
- Research WatchCancer Discov May 1 2019 9 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2019-044
Transcription
- Research WatchCancer Discov May 1 2019 9 (5) 576-576; DOI:10.1158/2159-8290.CD-RW2019-046
Volume 9, Issue 5
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