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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov June 1 2019 9 (6) 681-683; DOI:10.1158/2159-8290.CD-ITI9-6

In the Spotlight

  • In the Spotlight
    Back to the Future: Rethinking and Retooling IL2 in the Immune Checkpoint Inhibitor Era
    Ryan J. Sullivan
    Cancer Discov June 1 2019 9 (6) 694-695; DOI:10.1158/2159-8290.CD-19-0412

  • In the Spotlight
    RAS Mutations Are Not Created Equal
    G. Aaron Hobbs and Channing J. Der
    Cancer Discov June 1 2019 9 (6) 696-698; DOI:10.1158/2159-8290.CD-19-0406

  • In the Spotlight
    Kinase Networks Regulate Metabolism: I'D(H1) Never Have Guessed!
    Sarah Horton and Brian J.P. Huntly
    Cancer Discov June 1 2019 9 (6) 699-701; DOI:10.1158/2159-8290.CD-19-0373

Mini Review

  • Mini Review
    Tumor Neurobiology and the War of Nerves in Cancer
    Sam Faulkner, Phillip Jobling, Brayden March, Chen Chen Jiang and Hubert Hondermarck
    Cancer Discov June 1 2019 9 (6) 702-710; DOI:10.1158/2159-8290.CD-18-1398

Research Brief

  • Research Brief | AuthorChoice
    A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors
    Salah-Eddine Bentebibel, Michael E. Hurwitz, Chantale Bernatchez, Cara Haymaker, Courtney W. Hudgens, Harriet M. Kluger, Michael T. Tetzlaff, Mary A. Tagliaferri, Jonathan Zalevsky, Ute Hoch, Christie Fanton, Sandra Aung, Patrick Hwu, Brendan D. Curti, Nizar M. Tannir, Mario Sznol and Adi Diab
    Cancer Discov June 1 2019 9 (6) 711-721; DOI:10.1158/2159-8290.CD-18-1495

    NKTR-214, a human recombinant IL2 attached to releasable polyethylene glycol chains to bias against binding to the low-affinity IL2Rα chain, promotes disease stabilization and stimulates immune cell infiltration in solid tumors.

Research Articles

  • Research Articles | AuthorChoice
    PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer
    Constantia Pantelidou, Olmo Sonzogni, Mateus De Oliveria Taveira, Anita K. Mehta, Aditi Kothari, Dan Wang, Tanvi Visal, Michelle K. Li, Jocelin Pinto, Jessica A. Castrillon, Emily M. Cheney, Peter Bouwman, Jos Jonkers, Sven Rottenberg, Jennifer L. Guerriero, Gerburg M. Wulf and Geoffrey I. Shapiro
    Cancer Discov June 1 2019 9 (6) 722-737; DOI:10.1158/2159-8290.CD-18-1218

    PARP inhibition in BRCA-deficient TNBC tumors activates the cytosolic DNA-sensing cGAS/STING pathway to induce recruitment of CD8+ T cells to the tumor microenvironment.

  • Research Articles
    Tissue-Specific Oncogenic Activity of KRASA146T
    Emily J. Poulin, Asim K. Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, Joao A. Paulo, Tannie Q. Huang, Carolina Morales, Wei Yan, Joshua Cook, Jonathan A. Nowak, Douglas K. Brubaker, Brian A. Joughin, Christian W. Johnson, Rebecca A. DeStefanis, Phaedra C. Ghazi, Sudershan Gondi, Thomas E. Wales, Roxana E. Iacob, Lana Bogdanova, Jessica J. Gierut, Yina Li, John R. Engen, Pedro A. Perez-Mancera, Benjamin S. Braun, Steven P. Gygi, Douglas A. Lauffenburger, Kenneth D. Westover and Kevin M. Haigis
    Cancer Discov June 1 2019 9 (6) 738-755; DOI:10.1158/2159-8290.CD-18-1220

    Structural biology, mass spectrometry, and mouse modeling demonstrate the variable strength and tissue-specific effects of KRAS mutants in promoting cancer.

  • Research Articles | AuthorChoice
    Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer
    Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine and Jing Chen
    Cancer Discov June 1 2019 9 (6) 756-777; DOI:10.1158/2159-8290.CD-18-1040

    Two distinct oncogenic tyrosine kinase cascades promote the activation of wild-type and mutant IDH1 in diverse cancers through direct and indirect phosphorylation of the Y42 and Y341 residues

  • Research Articles | AuthorChoice
    Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis
    Jong Jin Jeong, Xiaorong Gu, Ji Nie, Sriram Sundaravel, Hui Liu, Wen-Liang Kuo, Tushar D. Bhagat, Kith Pradhan, John Cao, Sangeeta Nischal, Kathy L. McGraw, Sanchari Bhattacharyya, Michael R. Bishop, Andrew Artz, Michael J. Thirman, Alison Moliterno, Peng Ji, Ross L. Levine, Lucy A. Godley, Ulrich Steidl, James J. Bieker, Alan F. List, Yogen Saunthararajah, Chuan He, Amit Verma and Amittha Wickrema
    Cancer Discov June 1 2019 9 (6) 778-795; DOI:10.1158/2159-8290.CD-18-1138

    JAK2-mediated phosphorylation and activation of TET2 increases TET2 DNA hydroxymethylation activity during hematopoietic differentiation and in myeloproliferative disease

  • Research Articles
    A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
    Damien Roos-Weil, Camille Decaudin, Marine Armand, Véronique Della-Valle, M'boyba K. Diop, Hussein Ghamlouch, Virginie Ropars, Cécile Hérate, Diane Lara, Eric Durot, Rima Haddad, Elena Mylonas, Frederik Damm, Francoise Pflumio, Bilyana Stoilova, Marlen Metzner, Olivier Elemento, Philippe Dessen, Valérie Camara-Clayette, François-Loïc Cosset, Els Verhoeyen, Véronique Leblond, Vincent Ribrag, Pascale Cornillet-Lefebvre, Philippe Rameau, Nabih Azar, Frédéric Charlotte, Pierre Morel, Jean-Baptiste Charbonnier, Paresh Vyas, Thomas Mercher, Said Aoufouchi, Nathalie Droin, Christel Guillouf, Florence Nguyen-Khac and Olivier A. Bernard
    Cancer Discov June 1 2019 9 (6) 796-811; DOI:10.1158/2159-8290.CD-18-0873

    A mutation of SPI1 that is recurrent in Waldenström macroglobulinemia alters the DNA binding properties of SPI1 to activate genes typically regulated by other ETS transcription factors and confer a growth advantage.

News in Brief

  • News in Brief
    People
    Cancer Discov June 1 2019 9 (6) 684-684; DOI:10.1158/2159-8290.CD-NB2019-050

  • News in Brief
    Combating Acquired TRK Inhibitor Resistance
    Cancer Discov June 1 2019 9 (6) 684-685; DOI:10.1158/2159-8290.CD-NB2019-047

  • News in Brief
    Combo Therapy Beats Back Relapsed NSCLC
    Cancer Discov June 1 2019 9 (6) 685-685; DOI:10.1158/2159-8290.CD-NB2019-044

  • News in Brief
    Entinostat Helps Thwart Immunotherapy Resistance
    Cancer Discov June 1 2019 9 (6) 685-686; DOI:10.1158/2159-8290.CD-NB2019-048

  • News in Brief
    Noted
    Cancer Discov June 1 2019 9 (6) 686-686; DOI:10.1158/2159-8290.CD-NB2019-051

  • News in Brief
    Bempegaldesleukin Stimulates Immune Response
    Cancer Discov June 1 2019 9 (6) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2019-036

  • News in Brief
    Antibody–Drug Conjugate Kills Neuroblastoma Cells
    Cancer Discov June 1 2019 9 (6) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2019-052

  • News in Brief
    FDA Strives to Expand Trial Enrollment
    Cancer Discov June 1 2019 9 (6) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2019-049

  • News in Brief
    Maintenance Rucaparib Controls Some Pancreatic Cancers
    Cancer Discov June 1 2019 9 (6) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2019-043

  • News in Brief
    Umbralisib: Treatment for a Rare Lymphoma?
    Cancer Discov June 1 2019 9 (6) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2019-045

  • News in Brief
    Gilteritinib Likely New Standard Care for AML
    Cancer Discov June 1 2019 9 (6) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2019-046

News in Depth

  • News in Depth
    PD-1 Blockade in GBM: Uncovering Response Clues
    Cancer Discov June 1 2019 9 (6) 687-688; DOI:10.1158/2159-8290.CD-ND2019-001

Research Watch

  • Breast Cancer

    • Research Watch
      LLGL2 Promotes Adaptation to Nutrient Stress in ER+ Breast Cancer
      Cancer Discov June 1 2019 9 (6) 691-691; DOI:10.1158/2159-8290.CD-RW2019-063

  • Cancer Epigenetics

    • Research Watch
      Altered Androgen Receptor Activity Drives CHD1-Null Prostate Cancer
      Cancer Discov June 1 2019 9 (6) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2019-052

  • Cell Cycle

    • Research Watch
      p38γ Is a CDK-like Kinase That Drives Cell-Cycle Entry and Liver Tumorigenesis
      Cancer Discov June 1 2019 9 (6) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2019-061

  • Drug Resistance

    • Research Watch
      WNT Activation Mediates Asparaginase Sensitization in ALL
      Cancer Discov June 1 2019 9 (6) 690-690; DOI:10.1158/2159-8290.CD-RW2019-062

  • Epigenetics

    • Research Watch
      Histone H2BK120 Ubiquitination Stabilizes DOT1L on Nucleosomes
      Cancer Discov June 1 2019 9 (6) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2019-060

  • Glioma

    • Research Watch
      Distinct Transitional States of Glial Progenitors Drive Gliomagenesis
      Cancer Discov June 1 2019 9 (6) 692-692; DOI:10.1158/2159-8290.CD-RW2019-058

  • Immunology

    • Research Watch
      Fatty Acid Transport Regulates Neutrophil Function in Tumors
      Cancer Discov June 1 2019 9 (6) 692-692; DOI:10.1158/2159-8290.CD-RW2019-064

  • Immunotherapy

    • Research Watch
      CAR T Cell–Driven Trogocytosis Induces Antigen-Low Leukemia Relapse
      Cancer Discov June 1 2019 9 (6) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2019-053

    • Research Watch
      GPRC5D CAR T-cell Therapy Has Antitumor Activity in Multiple Myeloma
      Cancer Discov June 1 2019 9 (6) 690-690; DOI:10.1158/2159-8290.CD-RW2019-051

  • Leukemia

    • Research Watch
      Genomic Analysis Provides Insights into Acute Erythroleukemia
      Cancer Discov June 1 2019 9 (6) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2019-054

    • Research Watch
      AML Patients Relapse Post-Transplantation by Escaping Transferred Immune Cells
      Cancer Discov June 1 2019 9 (6) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2019-049

  • Metabolism

    • Research Watch
      Mitochondrial Phospholipid Production Regulates AML Survival
      Cancer Discov June 1 2019 9 (6) 693-693; DOI:10.1158/2159-8290.CD-RW2019-059

    • Research Watch
      Tumor Cells Scavenge Cholesterol from Tumor-Associated Macrophages
      Cancer Discov June 1 2019 9 (6) 691-691; DOI:10.1158/2159-8290.CD-RW2019-056

  • Myeloproliferative Neoplasms

    • Research Watch
      Mutant Calreticulin Displays Aberrant Chaperone Activity
      Cancer Discov June 1 2019 9 (6) 689-689; DOI:10.1158/2159-8290.CD-RW2019-048

  • Oncogenes

    • Research Watch
      Transposable Elements Regulate Oncogene Expression in Human Cancers
      Cancer Discov June 1 2019 9 (6) 689-689; DOI:10.1158/2159-8290.CD-RW2019-055

  • Pancreatic Cancer

    • Research Watch
      Combined EGFR and CRAF Inhibition Induces Complete PDAC Regression in Mice
      Cancer Discov June 1 2019 9 (6) 693-693; DOI:10.1158/2159-8290.CD-RW2019-057

    • Research Watch
      Syndecan 1 Mediates Macropinocytosis in Pancreatic Cancer
      Cancer Discov June 1 2019 9 (6) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2019-050

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Cancer Discovery: 9 (6)
June 2019
Volume 9, Issue 6
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