Table of Contents

Research Articles

• Research Articles | AuthorChoice

  PARP Inhibitor Efficacy Depends on CD8⁺ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

  Constantia Pantelidou, Olmo Sonzogni, Mateus De Oliveria Taveira, Anita K. Mehta, Aditi Kothari, Dan Wang, Tanvi Visal, Michelle K. Li, Jocelin Pinto, Jessica A. Castrillon, Emily M. Cheney, Peter Bouwman, Jos Jonkers, Sven Rottenberg, Jennifer L. Guerriero, Gerburg M. Wulf and Geoffrey I. Shapiro

  Cancer Discov June 1 2019 9 (6) 722-737; DOI:10.1158/2159-8290.CD-18-1218

  
  

  PARP inhibition in BRCA-deficient TNBC tumors activates the cytosolic DNA-sensing cGAS/STING pathway to induce recruitment of CD8⁺ T cells to the tumor microenvironment.

• Research Articles

  Tissue-Specific Oncogenic Activity of KRAS^A146T

  Emily J. Poulin, Asim K. Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, Joao A. Paulo, Tannie Q. Huang, Carolina Morales, Wei Yan, Joshua Cook, Jonathan A. Nowak, Douglas K. Brubaker, Brian A. Joughin, Christian W. Johnson, Rebecca A. DeStefanis, Phaedra C. Ghazi, Sudershan Gondi, Thomas E. Wales, Roxana E. Iacob, Lana Bogdanova, Jessica J. Gierut, Yina Li, John R. Engen, Pedro A. Perez-Mancera, Benjamin S. Braun, Steven P. Gygi, Douglas A. Lauffenburger, Kenneth D. Westover and Kevin M. Haigis

  Cancer Discov June 1 2019 9 (6) 738-755; DOI:10.1158/2159-8290.CD-18-1220

  
  

  Structural biology, mass spectrometry, and mouse modeling demonstrate the variable strength and tissue-specific effects of KRAS mutants in promoting cancer.

• Research Articles | AuthorChoice

  Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

  Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine and Jing Chen

  Cancer Discov June 1 2019 9 (6) 756-777; DOI:10.1158/2159-8290.CD-18-1040

  
  

  Two distinct oncogenic tyrosine kinase cascades promote the activation of wild-type and mutant IDH1 in diverse cancers through direct and indirect phosphorylation of the Y42 and Y341 residues

• Research Articles | AuthorChoice

  Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

  Jong Jin Jeong, Xiaorong Gu, Ji Nie, Sriram Sundaravel, Hui Liu, Wen-Liang Kuo, Tushar D. Bhagat, Kith Pradhan, John Cao, Sangeeta Nischal, Kathy L. McGraw, Sanchari Bhattacharyya, Michael R. Bishop, Andrew Artz, Michael J. Thirman, Alison Moliterno, Peng Ji, Ross L. Levine, Lucy A. Godley, Ulrich Steidl, James J. Bieker, Alan F. List, Yogen Saunthararajah, Chuan He, Amit Verma and Amittha Wickrema

  Cancer Discov June 1 2019 9 (6) 778-795; DOI:10.1158/2159-8290.CD-18-1138

  
  

  JAK2-mediated phosphorylation and activation of TET2 increases TET2 DNA hydroxymethylation activity during hematopoietic differentiation and in myeloproliferative disease

• Research Articles

  A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

  Damien Roos-Weil, Camille Decaudin, Marine Armand, Véronique Della-Valle, M'boyba K. Diop, Hussein Ghamlouch, Virginie Ropars, Cécile Hérate, Diane Lara, Eric Durot, Rima Haddad, Elena Mylonas, Frederik Damm, Francoise Pflumio, Bilyana Stoilova, Marlen Metzner, Olivier Elemento, Philippe Dessen, Valérie Camara-Clayette, François-Loïc Cosset, Els Verhoeyen, Véronique Leblond, Vincent Ribrag, Pascale Cornillet-Lefebvre, Philippe Rameau, Nabih Azar, Frédéric Charlotte, Pierre Morel, Jean-Baptiste Charbonnier, Paresh Vyas, Thomas Mercher, Said Aoufouchi, Nathalie Droin, Christel Guillouf, Florence Nguyen-Khac and Olivier A. Bernard

  Cancer Discov June 1 2019 9 (6) 796-811; DOI:10.1158/2159-8290.CD-18-0873

  
  

  A mutation of SPI1 that is recurrent in Waldenström macroglobulinemia alters the DNA binding properties of SPI1 to activate genes typically regulated by other ETS transcription factors and confer a growth advantage.