In This Issue
Cancer Discov June 1 2019 9 (6) 681-683; DOI:10.1158/2159-8290.CD-ITI9-6
NKTR-214, a human recombinant IL2 attached to releasable polyethylene glycol chains to bias against binding to the low-affinity IL2Rα chain, promotes disease stabilization and stimulates immune cell infiltration in solid tumors.
PARP inhibition in BRCA-deficient TNBC tumors activates the cytosolic DNA-sensing cGAS/STING pathway to induce recruitment of CD8+ T cells to the tumor microenvironment.
Structural biology, mass spectrometry, and mouse modeling demonstrate the variable strength and tissue-specific effects of KRAS mutants in promoting cancer.
Two distinct oncogenic tyrosine kinase cascades promote the activation of wild-type and mutant IDH1 in diverse cancers through direct and indirect phosphorylation of the Y42 and Y341 residues
JAK2-mediated phosphorylation and activation of TET2 increases TET2 DNA hydroxymethylation activity during hematopoietic differentiation and in myeloproliferative disease
A mutation of SPI1 that is recurrent in Waldenström macroglobulinemia alters the DNA binding properties of SPI1 to activate genes typically regulated by other ETS transcription factors and confer a growth advantage.