Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Discovery
Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov July 1 2019 9 (7) 813-816; DOI:10.1158/2159-8290.CD-ITI9-7

In the Spotlight

  • In the Spotlight
    Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids
    Sarah J. Hill and Alan D. D'Andrea
    Cancer Discov July 1 2019 9 (7) 828-830; DOI:10.1158/2159-8290.CD-19-0527

  • In the Spotlight
    Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade
    Michael R. Savona and Jeffrey C. Rathmell
    Cancer Discov July 1 2019 9 (7) 831-833; DOI:10.1158/2159-8290.CD-19-0510

  • In the Spotlight
    Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow
    Florent Duval and Michele De Palma
    Cancer Discov July 1 2019 9 (7) 834-836; DOI:10.1158/2159-8290.CD-19-0535

Review

  • Review
    Cellular Plasticity in Cancer
    Salina Yuan, Robert J. Norgard and Ben Z. Stanger
    Cancer Discov July 1 2019 9 (7) 837-851; DOI:10.1158/2159-8290.CD-19-0015

Research Articles

  • Research Articles
    Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
    Else Driehuis, Sigrid Kolders, Sacha Spelier, Kadi Lõhmussaar, Stefan M. Willems, Lot A. Devriese, Remco de Bree, Emma J. de Ruiter, Jeroen Korving, Harry Begthel, Johan H. van Es, Veerle Geurts, Gui-Wei He, Richard H. van Jaarsveld, Rurika Oka, Mauro J. Muraro, Judith Vivié, Maurice M.J.M. Zandvliet, Antoni P.A. Hendrickx, Nino Iakobachvili, Priya Sridevi, Onno Kranenburg, Ruben van Boxtel, Geert J.P.L. Kops, David A. Tuveson, Peter J. Peters, Alexander van Oudenaarden and Hans Clevers
    Cancer Discov July 1 2019 9 (7) 852-871; DOI:10.1158/2159-8290.CD-18-1522

    Organoids derived from head and neck squamous cell carcinoma (HNSCC) and matching normal tissue allow for the in vitro characterization of the genetics, histology, and drug sensitivity of HNSCC.

  • Research Articles
    Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
    Cihangir Duy, Matt Teater, Francine E. Garrett-Bakelman, Tak C. Lee, Cem Meydan, Jacob L. Glass, Meng Li, Johannes C. Hellmuth, Helai P. Mohammad, Kimberly N. Smitheman, Alan H. Shih, Omar Abdel-Wahab, Martin S. Tallman, Monica L. Guzman, David Muench, H. Leighton Grimes, Gail J. Roboz, Ryan G. Kruger, Caretha L. Creasy, Elisabeth M. Paietta, Ross L. Levine, Martin Carroll and Ari M. Melnick
    Cancer Discov July 1 2019 9 (7) 872-889; DOI:10.1158/2159-8290.CD-19-0106

    Analysis of a long-term primary acute myeloid leukemia (AML) ex vivo culture platform shows that combined targeting of enhancers with an LSD1 inhibitor and promoters with 5-azacytidine shows greater efficacy than monotherapy, particularly in TET2-mutant AML.

  • Research Articles
    Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment
    Xufeng Chen, Christina Glytsou, Hua Zhou, Sonali Narang, Denis E. Reyna, Andrea Lopez, Theodore Sakellaropoulos, Yixiao Gong, Andreas Kloetgen, Yoon Sing Yap, Eric Wang, Evripidis Gavathiotis, Aristotelis Tsirigos, Raoul Tibes and Iannis Aifantis
    Cancer Discov July 1 2019 9 (7) 890-909; DOI:10.1158/2159-8290.CD-19-0117

    Depletion of mitochondrial proteins involved in maintenance of mitochondrial function and structure including the chaperonin CLPB is synthetically lethal with venetoclax in acute myeloid leukemia cells.

  • Research Articles
    The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
    Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Tingting Liu, Courtney L. Jones, Angelo D'Alessandro, Rachel Culp-Hill, Amanda d'Almeida, Sunil K. Joshi, Mara Rosenberg, Cristina E. Tognon, Alexey V. Danilov, Brian J. Druker, Bill H. Chang, Shannon K McWeeney and Jeffrey W. Tyner
    Cancer Discov July 1 2019 9 (7) 910-925; DOI:10.1158/2159-8290.CD-19-0125

    Inactivation of p53 and proapoptotic proteins promotes resistance to venetoclax in acute myeloid leukemia by inducing changes in mitochondrial homeostasis and cellular metabolism.

  • Research Articles
    Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
    Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J.H. De Clercq, Man Xu, Stephen Wang, Michael D. Cameron, David E. Heppner, Bo Hee Shin, Thomas W. Gero, Annan Yang, Suzanne E. Dahlberg, Kwok-Kin Wong, Michael J. Eck, Nathanael S. Gray and Pasi A. Jänne
    Cancer Discov July 1 2019 9 (7) 926-943; DOI:10.1158/2159-8290.CD-18-0903

    An allosteric inhibitor of mutant EGFR is effective against common resistance mutations alone or in combination with mutant-selective ATP-competitive EGFR inhibitors.

  • Research Articles
    Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents
    Chen Lossos, Yunpeng Liu, Kellie E. Kolb, Amanda L. Christie, Alexandria Van Scoyk, Sanjay M. Prakadan, Kay Shigemori, Kristen E. Stevenson, Sara Morrow, Olivia D. Plana, Cameron Fraser, Kristen L. Jones, Huiyun Liu, Christian P. Pallasch, Rebecca Modiste, Quang-De Nguyen, Jeffrey W. Craig, Elizabeth A. Morgan, Francisco Vega, Jon C. Aster, Kristopher A. Sarosiek, Alex K. Shalek, Michael T. Hemann and David M. Weinstock
    Cancer Discov July 1 2019 9 (7) 944-961; DOI:10.1158/2159-8290.CD-18-1393

    Analysis of in vivo models of double-hit lymphoma reveals the molecular mechanism underlying the role of cyclophosphamide and other alkylating agents on tumor clearance and antibody resistance.

  • Research Articles | AuthorChoice
    A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1
    Evangelia Loizou, Ana Banito, Geulah Livshits, Yu-Jui Ho, Richard P. Koche, Francisco J. Sánchez-Rivera, Allison Mayle, Chi-Chao Chen, Savvas Kinalis, Frederik O. Bagger, Edward R. Kastenhuber, Benjamin H. Durham and Scott W. Lowe
    Cancer Discov July 1 2019 9 (7) 962-979; DOI:10.1158/2159-8290.CD-18-1391

    The gain-of-function mutant p53R172H upregulates the transcription factor FOXH1 to promote self-renewal in acute myeloid leukemia.

News in Brief

  • News in Brief
    People
    Cancer Discov July 1 2019 9 (7) 818-818; DOI:10.1158/2159-8290.CD-NB2019-053

  • News in Brief
    Anti-BCMA CAR T-cell Therapy Reins in Myeloma
    Cancer Discov July 1 2019 9 (7) 818-819; DOI:10.1158/2159-8290.CD-NB2019-063

  • News in Brief
    Study Verifies Value of Real-World Evidence
    Cancer Discov July 1 2019 9 (7) 819-819; DOI:10.1158/2159-8290.CD-NB2019-056

  • News in Brief
    Scientists See Human Cancer in Zebrafish
    Cancer Discov July 1 2019 9 (7) 819-820; DOI:10.1158/2159-8290.CD-NB2019-062

  • News in Brief
    Noted
    Cancer Discov July 1 2019 9 (7) 820-820; DOI:10.1158/2159-8290.CD-NB2019-054

  • News in Brief
    High ORRs Seen with Tagraxofusp-erzs in BPDCN
    Cancer Discov July 1 2019 9 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2019-061

  • News in Brief
    Immunotherapy Activates Unexpected Cell Death Mechanism
    Cancer Discov July 1 2019 9 (7) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2019-058

  • News in Brief
    Children Successfully MATCHed to Therapies
    Cancer Discov July 1 2019 9 (7) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2019-059

  • News in Brief
    Entrectinib Shows Pediatric Potential
    Cancer Discov July 1 2019 9 (7) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2019-060

  • News in Brief
    Early-Onset Colorectal Cancer Increasing: Why?
    Cancer Discov July 1 2019 9 (7) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2019-057

  • News in Brief
    CRISPR Screens Single Out WRN
    Cancer Discov July 1 2019 9 (7) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2019-055

News in Depth

  • News in Depth
    Understanding Hyperprogression in Cancer
    Cancer Discov July 1 2019 9 (7) 821-821; DOI:10.1158/2159-8290.CD-ND2019-003

  • News in Depth
    Microbiota Manipulated to Enhance Immunity
    Cancer Discov July 1 2019 9 (7) 822-822; DOI:10.1158/2159-8290.CD-ND2019-004

Research Watch

  • Cancer Stem Cells

    • Research Watch
      Tumor-Initiating Cells Are Reliant on Methionine to Promote Cancer
      Cancer Discov July 1 2019 9 (7) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2019-073

  • Clinical Trials

    • Research Watch
      Blockade of VEGFR and PD-L1 Inhibits Alveolar Soft-Part Sarcoma
      Cancer Discov July 1 2019 9 (7) 826-826; DOI:10.1158/2159-8290.CD-RW2019-076

  • DNA Repair

    • Research Watch
      Release of Paused Pol II Induces Double-Strand Breaks in Normal Cells
      Cancer Discov July 1 2019 9 (7) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2019-084

  • Epigenetics

    • Research Watch
      KMT9 Is an Epigenetic Writer That Controls Prostate Cancer Cell Growth
      Cancer Discov July 1 2019 9 (7) 824-824; DOI:10.1158/2159-8290.CD-RW2019-074

  • Immunology

    • Research Watch
      TMEM176B Is a Potential Inflammasome-Associated Immune Checkpoint
      Cancer Discov July 1 2019 9 (7) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2019-077

    • Research Watch
      PD-L1/CD80 cis Interactions Disrupt PD-L1–PD-1 Binding and Promote T-cell Function
      Cancer Discov July 1 2019 9 (7) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2019-075

  • Immunotherapy

    • Research Watch
      GITR Agonism Overcomes Resistance to Immunotherapy in Solid Tumors
      Cancer Discov July 1 2019 9 (7) 824-824; DOI:10.1158/2159-8290.CD-RW2019-070

    • Research Watch
      Tumor-Initiating Stem Cells Are Resistant to Immunotherapy
      Cancer Discov July 1 2019 9 (7) 823-823; DOI:10.1158/2159-8290.CD-RW2019-066

    • Research Watch
      Inhibition of CBM Complex Primes Tumors for Immune Checkpoint Therapy
      Cancer Discov July 1 2019 9 (7) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2019-078

  • Leukemia

    • Research Watch
      YTHDF2 Is Required for Leukemia Stem Cells Function in AML
      Cancer Discov July 1 2019 9 (7) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2019-069

  • Lung Cancer

    • Research Watch
      Reactivating RB via CDK2 Inhibition Reduces Lung Cancer Aggressiveness
      Cancer Discov July 1 2019 9 (7) 825-825; DOI:10.1158/2159-8290.CD-RW2019-072

  • Lymphoma

    • Research Watch
      Identification and Characterization of a Musculin Mutant in Lymphoma
      Cancer Discov July 1 2019 9 (7) 827-827; DOI:10.1158/2159-8290.CD-RW2019-082

  • Metabolism

    • Research Watch
      Blood Vessel Proximity Generates Metabolic Gradients in Glioblastoma
      Cancer Discov July 1 2019 9 (7) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2019-071

    • Research Watch
      NAD Metabolic Dependency Determines Therapeutic Sensitivity in Cancer
      Cancer Discov July 1 2019 9 (7) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2019-067

    • Research Watch
      Cholesterol Modulates Immune Checkpoint Expression in TILs
      Cancer Discov July 1 2019 9 (7) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2019-068

  • Neoantigens

    • Research Watch
      Oncogenic Gene Fusion-Derived Neoantigens Elicit Specific T-cell Responses
      Cancer Discov July 1 2019 9 (7) 823-823; DOI:10.1158/2159-8290.CD-RW2019-065

  • Organoids

    • Research Watch
      Loss of BAP1 Mediates Malignant Transformation of Liver Organoids
      Cancer Discov July 1 2019 9 (7) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2019-081

  • Prostate Cancer

    • Research Watch
      Mitochondrial Fission Promotes Prostate Cancer Stem-Cell Self-Renewal
      Cancer Discov July 1 2019 9 (7) 826-826; DOI:10.1158/2159-8290.CD-RW2019-083

  • Tumor Microenvironment

    • Research Watch
      CNS-Derived Neural Progenitors Mediate Neurogenesis in Prostate Cancer
      Cancer Discov July 1 2019 9 (7) 827-827; DOI:10.1158/2159-8290.CD-RW2019-079

  • Tumor Suppressors

    • Research Watch
      WWP1 Inhibition Rescues PTEN Tumor-Suppressive Activity
      Cancer Discov July 1 2019 9 (7) 825-825; DOI:10.1158/2159-8290.CD-RW2019-080

Corrections

  • Corrections | Free Article
    Correction: AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
    Cancer Discov July 1 2019 9 (7) 980-980; DOI:10.1158/2159-8290.CD-19-0577

  • Corrections | Free Article
    Correction: ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
    Cancer Discov July 1 2019 9 (7) 981-981; DOI:10.1158/2159-8290.CD-19-0632

Back to top
PreviousNext
Cancer Discovery: 9 (7)
July 2019
Volume 9, Issue 7
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

Jump to

  • In This Issue
  • In the Spotlight
  • Review
  • Research Articles
  • News in Brief
  • News in Depth
  • Research Watch
    • Cancer Stem Cells
    • Clinical Trials
    • DNA Repair
    • Epigenetics
    • Immunology
    • Immunotherapy
    • Leukemia
    • Lung Cancer
    • Lymphoma
    • Metabolism
    • Neoantigens
    • Organoids
    • Prostate Cancer
    • Tumor Microenvironment
    • Tumor Suppressors
  • Corrections
Advertisement
  • Most Cited
  • Most Read
Loading
  • The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
  • Macrophages Regulate Response to Chemotherapy
  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
  • PDX Models in Cancer Research
More...
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • OnlineFirst
  • Current Issue
  • Past Issues

Info For

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Discovery

  • About the Journal
  • Editors
  • Journal Sections
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

Advertisement