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Targeting Autophagy in Cancer: Recent Advances and Future Directions

Ravi K. Amaravadi, Alec C. Kimmelman and Jayanta Debnath
Ravi K. Amaravadi
1Abramson Cancer Center and the Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
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  • For correspondence: Ravi.amaravadi@pennmedicine.upenn.edu
Alec C. Kimmelman
2Department of Radiation Oncology, Perlmutter Cancer Center, New York University School of Medicine, New York, New York.
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Jayanta Debnath
3Department of Pathology, University of California, San Francisco, California.
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DOI: 10.1158/2159-8290.CD-19-0292 Published September 2019
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Article Information

Volume 9, Issue 9, pp. 1167-1181

DOI 
https://doi.org/10.1158/2159-8290.CD-19-0292
PubMed 
31434711

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received March 21, 2019
  • Revision received May 31, 2019
  • Accepted July 3, 2019
  • Published first August 21, 2019.

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  • Previous version (August 21, 2019 - 06:30).
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Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Ravi K. Amaravadi1,*,
  2. Alec C. Kimmelman2 and
  3. Jayanta Debnath3
  1. 1Abramson Cancer Center and the Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  2. 2Department of Radiation Oncology, Perlmutter Cancer Center, New York University School of Medicine, New York, New York.
  3. 3Department of Pathology, University of California, San Francisco, California.
  1. ↵*Corresponding Author:
    Ravi K. Amaravadi, University of Pennsylvania, 8th Floor BRB, 421 Curie Boulevard, Philadelphia, PA 19104. Phone: 215-796-5159; Fax: 215-349-8550; E-mail: Ravi.amaravadi{at}pennmedicine.upenn.edu
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Cancer Discovery: 9 (9)
September 2019
Volume 9, Issue 9
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Targeting Autophagy in Cancer: Recent Advances and Future Directions
Ravi K. Amaravadi, Alec C. Kimmelman and Jayanta Debnath
Cancer Discov September 1 2019 (9) (9) 1167-1181; DOI: 10.1158/2159-8290.CD-19-0292

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Targeting Autophagy in Cancer: Recent Advances and Future Directions
Ravi K. Amaravadi, Alec C. Kimmelman and Jayanta Debnath
Cancer Discov September 1 2019 (9) (9) 1167-1181; DOI: 10.1158/2159-8290.CD-19-0292
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  • Article
    • Abstract
    • Introduction
    • Autophagy: List of Key Autophagy Regulators Expands
    • Bulk Degradation and Selective Autophagy Can Both Affect the Cancer Phenotype
    • The Complex Role of Autophagy Cargo Receptors in Driving or Suppressing Tumor Growth
    • Autophagy Drives Tumor Growth of Established Tumors and Resistance to Therapy
    • Pathways and Stressors that Activate Autophagy in Cancer
    • Autophagy Plays a Critical Role in Both Tumor and Host Cells to Support Tumor Growth
    • Autophagy and Tumor Immunity
    • Determinants of Autophagy Dependency in Cancer
    • Tumor Genotypes Especially Sensitive to Combination Strategies Involving Autophagy Inhibitors
    • Repurposing HCQ in Clinical Oncology Trials
    • Novel Autophagy Inhibitors for Cancer
    • Summary and Future Directions
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
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