V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao; Ann Maria; Na Na; Arnaud da Cruz Paula; Alexander N. Gorelick; Jaclyn F. Hechtman; Julianne Carson; Robert A. Lefkowitz; Britta Weigelt; Barry S. Taylor; HuiYong Zhao; Jorge S. Reis-Filho; Elisa de Stanchina; Neal Rosen; Zhan Yao; Rona Yaeger

doi:10.1158/2159-8290.CD-19-0356

Research Brief

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao, Ann Maria, Na Na, Arnaud da Cruz Paula, Alexander N. Gorelick, Jaclyn F. Hechtman, Julianne Carson, Robert A. Lefkowitz, Britta Weigelt, Barry S. Taylor, HuiYong Zhao, Jorge S. Reis-Filho, Elisa de Stanchina, Neal Rosen, Zhan Yao and Rona Yaeger

Yijun Gao

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Ann Maria

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Na Na

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Arnaud da Cruz Paula

2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Alexander N. Gorelick

3Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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Jaclyn F. Hechtman

2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Julianne Carson

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Robert A. Lefkowitz

5Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Britta Weigelt

2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Barry S. Taylor

3Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

6Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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HuiYong Zhao

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Jorge S. Reis-Filho

2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Elisa de Stanchina

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Neal Rosen

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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ORCID record for Neal Rosen

Zhan Yao

1Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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Rona Yaeger

7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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For correspondence: yaegerr@mskcc.org

DOI: 10.1158/2159-8290.CD-19-0356 Published September 2019

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September 2019
Volume 9, Issue 9

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V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer