V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao; Ann Maria; Na Na; Arnaud da Cruz Paula; Alexander N. Gorelick; Jaclyn F. Hechtman; Julianne Carson; Robert A. Lefkowitz; Britta Weigelt; Barry S. Taylor; HuiYong Zhao; Jorge S. Reis-Filho; Elisa de Stanchina; Neal Rosen; Zhan Yao; Rona Yaeger

doi:10.1158/2159-8290.CD-19-0356

Research Brief

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao, Ann Maria, Na Na, Arnaud da Cruz Paula, Alexander N. Gorelick, Jaclyn F. Hechtman, Julianne Carson, Robert A. Lefkowitz, Britta Weigelt, Barry S. Taylor, HuiYong Zhao, Jorge S. Reis-Filho, Elisa de Stanchina, Neal Rosen, Zhan Yao and Rona Yaeger

Yijun Gao

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Ann Maria

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Na Na

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Arnaud da Cruz Paula

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Alexander N. Gorelick

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Jaclyn F. Hechtman

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Julianne Carson

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Robert A. Lefkowitz

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Britta Weigelt

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Barry S. Taylor

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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HuiYong Zhao

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Jorge S. Reis-Filho

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Elisa de Stanchina

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Neal Rosen

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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ORCID record for Neal Rosen

Zhan Yao

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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Rona Yaeger

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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For correspondence: yaegerr@mskcc.org

DOI: 10.1158/2159-8290.CD-19-0356 Published September 2019

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September 2019
Volume 9, Issue 9

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V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer