Table of Contents

Research Articles

• Research Articles

  Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T-cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms

  Cansu Cimen Bozkus, Vladimir Roudko, John P. Finnigan, John Mascarenhas, Ronald Hoffman, Camelia Iancu-Rubin and Nina Bhardwaj

  Cancer Discov September 1 2019 9 (9) 1192-1207; DOI:10.1158/2159-8290.CD-18-1356

  
  

  Myeloproliferative neoplasm–associated calreticulin mutations elicit T-cell responses that can be promoted by immune checkpoint blockade with pembrolizumab.

• Research Articles

  Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer

  Jaclyn Sceneay, Gregory J. Goreczny, Kristin Wilson, Sara Morrow, Molly J. DeCristo, Jessalyn M. Ubellacker, Yuanbo Qin, Tyler Laszewski, Daniel G. Stover, Victor Barrera, John N. Hutchinson, Rachel A. Freedman, Elizabeth A. Mittendorf and Sandra S. McAllister

  Cancer Discov September 1 2019 9 (9) 1208-1227; DOI:10.1158/2159-8290.CD-18-1454

  
  

  Immune dysfunction associated with age in a mouse model of TNBC leads to lack of response to immune checkpoint blockade treatment that can be rescued by the addition of a STING agonist.

• Research Articles

  Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

  Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis and Jian Xu

  Cancer Discov September 1 2019 9 (9) 1228-1247; DOI:10.1158/2159-8290.CD-19-0152

  
  

  Knockout of the PRC2 component EZH2 and activating NRAS mutations cooperate to cause MPN progression to leukemia by upregulating the BCAA-metabolism enzyme BCAT1.

• Research Articles

  Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling

  Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich

  Cancer Discov September 1 2019 9 (9) 1248-1267; DOI:10.1158/2159-8290.CD-19-0061

  
  

  Glioma stem cells upregulate the polyunsaturated synthesis enzyme ELOVL2, which alters cell-membrane properties and composition to maintain EGFR signaling.

• Research Articles | AuthorChoice

  Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

  Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu, Georgi N. Yordanov, Carl S. Leonhardt, Melissa A. Yao, Priya Alagesan, Maya N. Zaatari, Youngkyu Park, Jeremy N. Skepper, Kay F. Macleod, Pedro A. Perez-Mancera, Michael P. Murphy, Gerard I. Evan, Karen H. Vousden and David A. Tuveson

  Cancer Discov September 1 2019 9 (9) 1268-1287; DOI:10.1158/2159-8290.CD-18-1409

  
  

  Activating Kras mutations cause upregulation of the mitophagy-promoting protein NIX, which alters mitochondrial function and enhances redox capacity to support progression of pancreatic cancer.

• Research Articles | AuthorChoice

  Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming

  Mautin Hundeyin, Emma Kurz, Ankita Mishra, Juan Andres Kochen Rossi, Shannon M. Liudahl, Kenna R. Leis, Harshita Mehrotra, Mirhee Kim, Luisana E. Torres, Adesola Ogunsakin, Jason Link, Rosalie C. Sears, Shamilene Sivagnanam, Jeremy Goecks, K.M. Sadeq Islam, Igor Dolgalev, Shivraj Savadkar, Wei Wang, Berk Aykut, Joshua Leinwand, Brian Diskin, Salma Adam, Muhammad Israr, Maeliss Gelas, Justin Lish, Kathryn Chin, Mohammad Saad Farooq, Benjamin Wadowski, Jingjing Wu, Suhagi Shah, Dennis O. Adeegbe, Smruti Pushalkar, Varshini Vasudevaraja, Deepak Saxena, Kwok-Kin Wong, Lisa M. Coussens and George Miller

  Cancer Discov September 1 2019 9 (9) 1288-1305; DOI:10.1158/2159-8290.CD-19-0161

  
  

  Innate αβ T cells are a significant component of the tumor microenvironment in pancreatic ductal adenocarcinoma and delay tumor growth in mouse and human models.

• Research Articles | AuthorChoice

  PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

  Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita Venugopal Menon, Jesse M. Katon, Chih-Hung Hsu, John M. Asara, Priyanka Tibarewal, Nicholas R. Leslie, Yang Shi, Pier Paolo Pandolfi and Wenyi Wei

  Cancer Discov September 1 2019 9 (9) 1306-1323; DOI:10.1158/2159-8290.CD-18-0083

  
  

  Efficient repair of DNA double-strand breaks depends on NSD2-mediated dimethylation of PTEN and its interaction with p53-binding protein 1.