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The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages
Ilaria Marigo, Rosalinda Trovato, Francesca Hofer, Vincenzo Ingangi, Giacomo Desantis, Kevin Leone, Francesco De Sanctis, Stefano Ugel, Stefania Cane, Anna Simonelli, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Massimo Rugge, Federico Boschi, Giulia Borile, Thomas Eisenhaure, Siranush Sarkizova, David Lieb, Nir Hacohen, Luca Azzolin, Stefano Piccolo, Rita Lawlor, Aldo Scarpa, Luisa Carbognin, Emilio Bria, Silvio Bicciato, Peter J Murray, Vincenzo Bronte

Cancer Discovery Jan 2020, CD-20-0036; DOI: 10.1158/2159-8290.CD-20-0036
First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors
Timothy A. Yap, David SP Tan, Angelika Terbuch, Reece Caldwell, Christina Guo, Boon Cher Goh, Valerie Heong, Noor R Md Haris, Saira Bashir, Yvette Drew, David S. Hong, Funda Meric-Bernstam, Gary Wilkinson, Joseph Hreiki, Antje M. Wengner, Friedhelm Bladt, Andreas Schlicker, Matthias Ludwig, Yinghui Zhou, Li Liu, Sonal Bordia, Ruth Plummer, Eleni Lagkadinou, Johann S. de Bono

Cancer Discovery Jan 2020, CD-20-0868; DOI: 10.1158/2159-8290.CD-20-0868
Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Stephen Sakuma, Marcela Raices, Joana Borlido, Valeria Guglielmi, Ethan Y.S. Zhu, Maximiliano A D'Angelo

Cancer Discovery Jan 2020, CD-20-0581; DOI: 10.1158/2159-8290.CD-20-0581
An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis
Mei Chen, Xuelan Chen, Shujun Li, Xiangyu Pan, Yanqiu Gong, Jianan Zheng, Jing Xu, Chengjian zhao, Qi Zhang, Shan Zhang, Lu Qi, Zhongwang Wang, Kaidou Shi, Bi-Sen Ding, Zhihong Xue, Lu Chen, Shengyong Yang, Yuan Wang, Ting Niu, Lunzhi Dai, Scott W. Lowe, Chong Chen, Yu Liu

Cancer Discovery Jan 2020, CD-20-0336; DOI: 10.1158/2159-8290.CD-20-0336
Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain
Susanne Grunewald, Lillian R Klug, Thomas Muhlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Juergen Treckmann, Jonathan A. Fletcher, Sascha Jung, Paul Czodrowski, Stephen Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C Heinrich, Sebastian Bauer

Cancer Discovery Jan 2020, CD-20-0487; DOI: 10.1158/2159-8290.CD-20-0487
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone
Sima Khazaei, Nicolas De Jay, Shriya Deshmukh, Liam D Hendrikse, Wajih Jawhar, Carol CL Chen, Leonie G Mikael, Damien Faury, Dylan M Marchione, Joel Lanoix, Eric Bonneil, Takeaki Ishii, Siddhant U Jain, Kateryna Rossokhata, Tianna S Sihota, Robert Eveleigh, Veronique Lisi, Ashot S Harutyunyan, Sungmi Jung, Jason Karamchandani, Brendan C Dickson, Robert Turcotte, Jay S Wunder, Pierre Thibault, Peter W Lewis, Benjamin A Garcia, Stephen C. Mack, Michael D Taylor, Livia Garzia, Claudia L Kleinman, Nada Jabado

Cancer Discovery Jan 2020, CD-20-0461; DOI: 10.1158/2159-8290.CD-20-0461
Triplet therapy with palbociclib, taselisib and fulvestrant in PIK3CA mutant breast cancer and doublet palbociclib and taselisib in pathway mutant solid cancers.
Javier Pascual, Joline S.J. Lim, Iain R J Macpherson, Anne C Armstrong, Alistair Ring, Alicia FC Okines, Rosalind J Cutts, Maria Teresa Herrera-Abreu, Isaac Garcia-Murillas, Alex Pearson, Sarah Hrebien, Heidrun Gevensleben, Paula Z Proszek, Michael Hubank, Margaret Hills, Jenny King, Mona Parmar, Toby Prout, Laura Finneran, Jason Malia, Karen E Swales, Ruth Ruddle, Florence I. Raynaud, Alison Turner, Emma Hall, Timothy A. Yap, Juanita S Lopez, Nicholas C. Turner

Cancer Discovery Jan 2020, CD-20-0553; DOI: 10.1158/2159-8290.CD-20-0553
Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers
Timothy A. Yap, Rebecca Kristeleit, Vasiliki Michalarea, Stephen J. Pettitt, Joline S.J. Lim, Suzanne Carreira, Desamparados Roda, Rowan Miller, Ruth Riisnaes, Susana Miranda, Ines Figueiredo, Daniel Nava Rodrigues, Sarah Ward, Ruth Matthews, Mona Parmar, Alison Turner, Nina Tunariu, Neha Chopra, Heidrun Gevensleben, Nicholas C. Turner, Ruth Ruddle, Florence I. Raynaud, Shaun Decordova, Karen E. Swales, Laura Finneran, Emma Hall, Paul Rugman, Justin P.O. Lindemann, Andrew Foxley, Christopher J. Lord, Udai Banerji, Ruth Plummer, Bristi Basu, Juanita S. Lopez, Yvette Drew, Johann S. de Bono

Cancer Discovery Jun 2020, DOI: 10.1158/2159-8290.CD-20-0163
Pharmacological suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers
Xinxin Song, Zhuan Zhou, Hongchun Li, Yifan Xue, Xinghua Lu, Ivet Bahar, Oliver Kepp, Mien-Chie Hung, Guido Kroemer, Yong Wan

Cancer Discovery Jan 2020, CD-20-0402; DOI: 10.1158/2159-8290.CD-20-0402
Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML
Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L Glass, Alan H. Shih, Ruud Delwel, Ross L Levine, Christopher E Mason, Ari M Melnick

Cancer Discovery Jan 2020, CD-19-0897; DOI: 10.1158/2159-8290.CD-19-0897

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