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Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling

Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich
Ryan C. Gimple
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.Department of Pathology, Case Western University, Cleveland, Ohio.
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  • ORCID record for Ryan C. Gimple
Reilly L. Kidwell
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Leo J.Y. Kim
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.Department of Pathology, Case Western University, Cleveland, Ohio.
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  • ORCID record for Leo J.Y. Kim
Tengqian Sun
Salk Institute for Biological Studies, La Jolla, California.
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Anthony D. Gromovsky
Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
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Qiulian Wu
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Megan Wolf
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
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Deguan Lv
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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  • ORCID record for Deguan Lv
Shruti Bhargava
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Li Jiang
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Briana C. Prager
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.Department of Pathology, Case Western University, Cleveland, Ohio.Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
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Xiuxing Wang
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Qing Ye
Salk Institute for Biological Studies, La Jolla, California.
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Zhe Zhu
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Guoxin Zhang
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Zhen Dong
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Linjie Zhao
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Derrick Lee
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
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Junfeng Bi
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California.
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Andrew E. Sloan
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland Ohio.Department of Neurological Surgery, University Hospitals–Cleveland Medical Center, Cleveland, Ohio.
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Paul S. Mischel
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California.Department of Pathology, UCSD School of Medicine, La Jolla, California.Moores Cancer Center, UCSD School of Medicine, La Jolla, California.
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J. Mark Brown
Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
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Hu Cang
Salk Institute for Biological Studies, La Jolla, California.
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Tao Huan
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
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Stephen C. Mack
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.Dan L. Duncan Cancer Center, Houston, Texas.
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Qi Xie
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, China.
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  • For correspondence: jerich@ucsd.edu xieqi@westlake.edu.cn
Jeremy N. Rich
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.Moores Cancer Center, UCSD School of Medicine, La Jolla, California.Department of Neurosciences, UCSD School of Medicine, La Jolla, California.
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  • For correspondence: jerich@ucsd.edu xieqi@westlake.edu.cn
DOI: 10.1158/2159-8290.CD-19-0061
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Article Information

DOI 
https://doi.org/10.1158/2159-8290.CD-19-0061
PubMed 
31201181

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received January 15, 2019
  • Revision received May 3, 2019
  • Accepted June 11, 2019
  • Published first June 14, 2019.

Article Versions

  • Previous version (June 14, 2019 - 06:08).
  • You are currently viewing a Previous version of this article (August 20, 2019 - 06:49).
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Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Ryan C. Gimple1,2,
  2. Reilly L. Kidwell1,
  3. Leo J.Y. Kim1,2,
  4. Tengqian Sun3,
  5. Anthony D. Gromovsky4,
  6. Qiulian Wu1,
  7. Megan Wolf5,
  8. Deguan Lv1,
  9. Shruti Bhargava1,
  10. Li Jiang1,
  11. Briana C. Prager1,2,6,
  12. Xiuxing Wang1,
  13. Qing Ye3,
  14. Zhe Zhu1,
  15. Guoxin Zhang1,
  16. Zhen Dong1,
  17. Linjie Zhao1,
  18. Derrick Lee1,
  19. Junfeng Bi7,
  20. Andrew E. Sloan8,9,
  21. Paul S. Mischel7,10,11,
  22. J. Mark Brown4,
  23. Hu Cang3,
  24. Tao Huan5,
  25. Stephen C. Mack12,13,
  26. Qi Xie1,14,* and
  27. Jeremy N. Rich1,11,15,*
  1. 1Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.
  2. 2Department of Pathology, Case Western University, Cleveland, Ohio.
  3. 3Salk Institute for Biological Studies, La Jolla, California.
  4. 4Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
  5. 5Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
  6. 6Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
  7. 7Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California.
  8. 8Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland Ohio.
  9. 9Department of Neurological Surgery, University Hospitals–Cleveland Medical Center, Cleveland, Ohio.
  10. 10Department of Pathology, UCSD School of Medicine, La Jolla, California.
  11. 11Moores Cancer Center, UCSD School of Medicine, La Jolla, California.
  12. 12Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
  13. 13Dan L. Duncan Cancer Center, Houston, Texas.
  14. 14Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, China.
  15. 15Department of Neurosciences, UCSD School of Medicine, La Jolla, California.
  1. ↵*Corresponding Authors:
    Jeremy N. Rich, UCSD School of Medicine, 3855 Health Sciences Drive, La Jolla, CA 92093. Phone: 858-822-2703; E-mail: jerich{at}ucsd.edu; and Qi Xie, Westlake University, No. 18, Shilongshan Road, Cloud Town, Xihu District, Hangzhou, Zhejiang Province 310024, China. Phone: 8615-5012-01789; E-mail: xieqi{at}westlake.edu.cn
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Published OnlineFirst August 20, 2019
doi: 10.1158/2159-8290.CD-19-0061

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Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich
Cancer Discov August 20 2019 DOI: 10.1158/2159-8290.CD-19-0061

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Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich
Cancer Discov August 20 2019 DOI: 10.1158/2159-8290.CD-19-0061
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