Combination approach uncovers novel treatment avenues.
With longer follow-up, PFS increases; early OS results seem promising.
NCI initiative yields mechanistic explanations for nearly one quarter of standout responses.
KO-539 induced complete remissions in two patients with relapsed/refractory disease.
Mutations promoting myeloproliferative neoplasms might be established decades before diagnosis.
Patients hesitant to return to health centers; missed exams mean more advanced disease.
Strategies include broadening eligibility criteria and reaching out to minority, low-income patients.
Age, status of cancer treatment, and cancer prognosis can determine how patients will fare.
Prior work in oncology underpins the record-breaking speed of development.
B-cell expression of the EBV protein LMP1 elicited T-cell responses against tumor-associated antigens.
FBXO44 bound H3K9me3 at replication forks, recruiting a complex to repress repetitive elements.
Structural and biochemical analyses uncovered the substrate binding and transport mechanisms of MCT1.
Sotigalimab had manageable toxicity and an early efficacy signal in a phase Ib pancreatic cancer trial.
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