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Cancer Discovery
Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
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  • Articles
    • OnlineFirst
    • Current Issue
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      • COVID-19 & Cancer Resource Center
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      • "Best of" Collection
  • For Authors
    • Information for Authors
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    • Best of: Author Profiles
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OnlineFirst

In Focus

  • In Focus
    A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer
    Portia L. Thomas, Chioma J. Madubata, Melinda C. Aldrich, Montessa M. Lee, Taofeek K. Owonikoko, John D. Minna, Charles M. Rudin, Julien Sage and Christine M. Lovly
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-1592

News in Brief

  • News in Brief
    Proteomics Sharpens Brain Tumor Genomic Analysis
    Cancer Discov January 7 2021 DOI:10.1158/2159-8290.CD-NB2020-119

    Combination approach uncovers novel treatment avenues.

  • News in Brief
    More Data, More Benefit with T-DXd in Breast Cancer
    Cancer Discov January 5 2021 DOI:10.1158/2159-8290.CD-NB2020-121

    With longer follow-up, PFS increases; early OS results seem promising.

  • News in Brief
    Piecing the Puzzle of Exceptional Responders
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-NB2020-118

    NCI initiative yields mechanistic explanations for nearly one quarter of standout responses.

  • News in Brief
    AML Prognoses Better with Menin–MLL Inhibitor?
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-NB2020-120

    KO-539 induced complete remissions in two patients with relapsed/refractory disease.

  • News in Brief
    MPN Driver Mutations May Occur In Utero
    Cancer Discov December 29 2020 DOI:10.1158/2159-8290.CD-NB2020-117

    Mutations promoting myeloproliferative neoplasms might be established decades before diagnosis.

  • News in Brief | Free Article
    As Pandemic Continues, Screening Concerns Grow
    Cancer Discov December 22 2020 DOI:10.1158/2159-8290.CD-NB2020-116

    Patients hesitant to return to health centers; missed exams mean more advanced disease.

  • News in Brief
    FDA Encourages Greater Trial Diversity
    Cancer Discov December 21 2020 DOI:10.1158/2159-8290.CD-NB2020-115

    Strategies include broadening eligibility criteria and reaching out to minority, low-income patients.

  • News in Brief | Free Article
    Survival Factors ID'd for Patients with Blood Cancer + COVID-19
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-NB2020-112

    Age, status of cancer treatment, and cancer prognosis can determine how patients will fare.

News in Depth

  • News in Depth | Free Article
    Cancer Immunotherapies Helped Shape COVID Vaccines
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-ND2020-018

    Prior work in oncology underpins the record-breaking speed of development.

Research Article

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation
    Yuan-Hung Lo, Kevin S. Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D. Sobba, Kasper Karlsson, Sunny J. Jones, Teri A Longacre, Amanda T. Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S. Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R. Crabtree and Calvin J. Kuo
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-1109

  • Research Article | AUTHOR MANUSCRIPT
    CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
    Dongrui Wang, Briana C Prager, Ryan C Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu, Leo J.Y Kim, Zhixin Qiu, Peng Lin, Michael H. Lorenzini, Behnam Badie, Stephen J Forman, Qi Xie, Christine E Brown and Jeremy N. Rich
    Cancer Discov January 13 2021 DOI:10.1158/2159-8290.CD-20-1243

  • Research Article | AUTHOR MANUSCRIPT
    Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia
    Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R. Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C. Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P. Gregory, Stephin J Vervoort, Kristin K Brown and Ricky W. Johnstone
    Cancer Discov January 12 2021 DOI:10.1158/2159-8290.CD-20-0738

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Targeting p300/CBP axis in lethal prostate cancer
    Jonathan Welti, Adam Sharp, Nigel Brooks, Wei Yuan, Christopher McNair, Saswati N Chand, Abhijit Pal, Ines Figueiredo, Ruth Riisnaes, Bora Gurel, Jan Rekowski, Denisa Bogdan, William West, Barbara Young, Meera Raja, Amy Prosser, Jordan Lane, Stuart Thomson, Jenny Worthington, Stuart Onions, Jonathan Shannon, Silvia Paoletta, Richard Brown, Don Smyth, Gareth W Harbottle, Veronica S Gil, Susana Miranda, Mateus Crespo, Ana Ferreira, Rita Pereira, Nina Tunariu, Suzanne Carreira, Antje J Neeb, Jian Ning, Amanda Swain, David Taddei, Stand Up to Cancer-PCF International Dream Team, Matthew J Schiewer, Karen E Knudsen, Neil Pegg and Johann S. de Bono
    Cancer Discov January 11 2021 DOI:10.1158/2159-8290.CD-20-0751

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem
    Clay McLeod, Alexander M Gout, Xin Zhou, Andrew Thrasher, Delaram Rahbarinia, Samuel Warren Brady, Michael Macias, Kirby Birch, David Finkelstein, Jobin Sunny, Rahul Mudunuri, Brent A. Orr, Madison Treadway, Bob Davidson, Tracy K. Ard, Arthur Chiao, Andrew Swistak, Stephanie Wiggins, Scott Foy, Jian Wang, Edgar Sioson, Shuoguo Wang, J Robert Michael, Yu Liu, Xiaotu Ma, Aman Patel, Michael N Edmonson, Mark R Wilkinson, Andrew M Frantz, Ti-Cheng Chang, Liqing Tian, Shaohua Lei, S. M. Ashiqul Islam, Christopher Meyer, Naina Thangaraj, Pamella Tater, Vijay Kandali, Singer Ma, Tuan Nguyen, Omar Abdulgafoor Serang, Irina McGuire, Nedra Robison, Darrell Gentry, Xing Tang, Lance E Palmer, Gang Wu, Ed Suh, Leigh Tanner, James McMurry, Matthew Lear, Alberto S. Pappo, Zhaoming Wang, Carmen L. Wilson, Yong Cheng, Soheil Meshinchi, Ludmil B. Alexandrov, Mitchell J Weiss, Gregory T. Armstrong, Leslie L. Robison, Yutaka Yasui, Kim E. Nichols, David W. Ellison, Chaitanya Bangur, Charles G. Mullighan, Suzanne J. Baker, Michael A. Dyer, Geralyn Miller, Scott Newman, Michael Rusch, Richard Daly, Keith Perry, James R. Downing and Jinghui Zhang
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-20-1230

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells
    Simon J Dovedi, Matthew J Elder, Chunning Yang, Suzanne I Sitnikova, Lorraine Irving, Anna Hansen, James Hair, Des C Jones, Sumati Hasani, Bo Wang, Seock-Ah Im, Ben Tran, Deepa S Subramaniam, Shelby D Gainer, Kapil Vashisht, Arthur Lewis, Xiaofang Jin, Stacy Kentner, Kathy Mulgrew, Yaya Wang, Michael G Overstreet, James Dodgson, Yanli Wu, Asis Palazón, Michelle Morrow, Godfrey J Rainey, Gareth J Browne, Frances Neal, Thomas V Murray, Aleksandra D Toloczko, William Dall'Acqua, Ikbel Achour, Daniel J Freeman, Robert W Wilkinson and Yariv Mazor
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-20-1445

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes
    Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears and Dipali Sharma
    Cancer Discov January 6 2021 DOI:10.1158/2159-8290.CD-20-0537

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Metastasis and immune evasion from extracellular cGAMP hydrolysis
    Jun Li, Mercedes A Duran, Ninjit Dhanota, Walid K. Chatila, Sarah E Bettigole, John Kwon, Roshan K Sriram, Matthew Philip Humphries, Manuel Salto-Tellez, Jacqueline A. James, Matthew G Hanna, Johannes C. Melms, Sreeram Vallabhaneni, Kevin Litchfield, Ieva Usaite, Dhruva Biswas, Rohan Bareja, Hao Wei Li, Maria Laura Martin, Princesca Dorsaint, Julie-Ann Cavallo, Peng Li, Chantal Pauli, Lee Gottesdiener, Benjamin J DiPardo, Travis J Hollmann, Taha Merghoub, Hannah Y Wen, Jorge S. Reis-Filho, Nadeem Riaz, Shin-San Michael Su, Anusha Kalbasi, Neil Vasan, Simon N Powell, Jedd D. Wolchok, Olivier Elemento, Charles Swanton, Alexander N Shoushtari, Eileen E Parkes, Benjamin Izar and Samuel F Bakhoum
    Cancer Discov December 28 2020 DOI:10.1158/2159-8290.CD-20-0387

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing
    Matthias Jürgen Schmitt, Carlos Company, Yuliia Dramaretska, Iros Barozzi, Andreas Göhrig, Sonia Kertalli, Melanie Großmann, Heike Naumann, Maria Pilar Sanchez-Bailon, Danielle Hulsman, Rainer Glass, Massimo Squatrito, Michela Serresi and Gaetano Gargiulo
    Cancer Discov December 23 2020 DOI:10.1158/2159-8290.CD-20-0219

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Endogenous retroelement activation by epigenetic therapy reverses the Warburg effect and elicits mitochondrial-mediated cancer cell death
    Vicente Fresquet, Maria J. Garcia-Barchino, Marta J. Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria Jose Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Álvaro Martínez-Baztán, Bruno Paiva, Maria J Moreno-Aliaga, Maria D Odero, Xabier Agirre, Oscar Yanes, Felipe Prósper and Jose A Martinez-Climent
    Cancer Discov December 19 2020 DOI:10.1158/2159-8290.CD-20-1065

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells
    Jiil Chung, Yosef E Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J Haradhvala, Vanessa Bianchi, Melissa Edwards, Victoria J. Forster, Nuno M Nunes, Melissa A. Galati, Martin Komosa, Shriya Deshmukh, Vanja Cabric, Scott Davidson, Matthew Zatzman, Nicholas Light, Reid Hayes, Ledia Brunga, Nathaniel D Anderson, Ben Ho, Karl P. Hodel, Robert Siddaway, A. Sorana Morrissy, Daniel C Bowers, Valérie Larouche, Annika Bronsema, Michael Osborn, Kristina A. Cole, Enrico Opocher, Gary Mason, Gregory A Thomas, Ben George, David S Ziegler, Scott Lindhorst, Magimairajan Vanan, Michal Yalon-Oren, Alyssa T Reddy, Maura Massimino, Patrick Tomboc, An Van Damme, Alexander Lossos, Carol Durno, Melyssa Aronson, Daniel A Morgenstern, Eric Bouffet, Annie Huang, Michael D Taylor, Anita Villani, David Malkin, Cynthia E. Hawkins, Zachary F. Pursell, Adam Shlien, Thomas A Kunkel, Gad Getz and Uri Tabori
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-20-0790

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Direct and Indirect Regulators of Epithelial-Mesenchymal Transition (EMT)-mediated Immunosuppression in Breast Carcinomas
    Anushka Dongre, Mohammad Rashidian, Elinor Ng Eaton, Ferenc Reinhardt, Prathapan Thiru, Maria Zagorulya, Sunita Nepal, Tuba Banaz, Anna Martner, Stefani Spranger and Robert A. Weinberg
    Cancer Discov December 16 2020 DOI:10.1158/2159-8290.CD-20-0603

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression
    John R P Knight, Constantinos Alexandrou, George L Skalka, Nikola Vlahov, Kathryn Pennel, Leah Officer, Ana Teodosio, Georgios Kanellos, David M Gay, Sebastian May-Wilson, Ewan M Smith, Arafath K Najumudeen, Kathryn Gilroy, Rachel A Ridgway, Dustin J Flanagan, Rachael C.L. Smith, Laura McDonald, Craig MacKay, Anne Cheasty, Kerri McArthur, Emma Stanway, Joshua D.G. Leach, Rene Jackstadt, Joseph A Waldron, Andrew D Campbell, Georgios Vlachogiannis, Nicola Valeri, Kevin M. Haigis, Nahum Sonenberg, Christopher G Proud, Neil P Jones, Martin E Swarbrick, Heather J. McKinnon, William J Faller, John Le Quesne, Joanne Edwards, Anne Elizabeth Willis, Martin Bushell and Owen J. Sansom
    Cancer Discov December 16 2020 DOI:10.1158/2159-8290.CD-20-0652

  • Research Article | AUTHOR MANUSCRIPT
    Gut microbiome directs hepatocytes to recruit MDSC and promote cholangiocarcinoma
    Qianfei Zhang, Chi Ma, Yi Duan, Bernd Heinrich, Umberto Rosato, Laurence P. Diggs, Lichun Ma, Soumen Roy, Qiong Fu, Zachary J. Brown, Simon Wabitsch, Vishal Thovarai, Jianyang Fu, Dechun Feng, Benjamin Ruf, Linda L Cui, Varun Subramanyam, Karen M Frank, Sophie Wang, David E Kleiner, Thomas Ritz, Christian Rupp, Bin Gao, Thomas Longerich, Alexander Kroemer, Xin Wei Wang, Mathuros Ruchirawat, Firouzeh Korangy, Bernd Schnabl, Giorgio Trinchieri and Tim F Greten
    Cancer Discov December 15 2020 DOI:10.1158/2159-8290.CD-20-0304

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity
    Aayoung Hong, Marco Piva, Sixue Liu, Willy Hugo, Shirley H. Lomeli, Vincent Zoete, Christopher E Randolph, Zhentao Yang, Yan Wang, Jordan J. Lee, Skylar J. Lo, Lu Sun, Agustin Vega-Crespo, Alejandro J Garcia, David B. Shackelford, Steven M. Dubinett, Philip O. Scumpia, Stephanie D. Byrum, Alan J. Tackett, Timothy R. Donahue, Olivier Michielin, Sheri L Holmen, Antoni Ribas, Gatien Moriceau and Roger S. Lo
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-0873

  • Research Article | AUTHOR MANUSCRIPT
    SWI/SNF complex mutations promote thyroid tumor progression and insensitivity to redifferentiation therapies.
    Mahesh Saqcena, Luis Javier Leandro-Garcia, Jesper L.V. Maag, Vatche Tchekmedyian, Gnana P. Krishnamoorthy, Prasanna P. Tamarapu, Vera Tiedje, Vincent Reuter, Jeffrey A. Knauf, Elisa de Stanchina, Bin Xu, Xiao-Hui Liao, Samuel Refetoff, Ronald Ghossein, Ping Chi, Alan L. Ho, Richard P. Koche and James A. Fagin
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-0735

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia
    Bhavana Bhatnagar, Jessica Kohlschmidt, Krzysztof Mrózek, Qiuhong Zhao, James L. Fisher, Deedra Nicolet, Christopher J. Walker, Alice S Mims, Christopher Oakes, Brian Giacopelli, Shelley Orwick, Isaiah Boateng, James S. Blachly, Sophia E Maharry, Andrew J Carroll, Bayard L Powell, Jonathan E Kolitz, Richard M. Stone, John C. Byrd, Electra D. Paskett, Albert de la Chapelle, Ramiro Garzon and Ann-Kathrin Eisfeld
    Cancer Discov December 4 2020 DOI:10.1158/2159-8290.CD-20-1579

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Personalized antibodies for gastroesophageal adenocarcinoma (PANGEA): a phase 2 study evaluating an individualized treatment strategy for metastatic disease
    Daniel V. T. Catenacci, Stephanie Moya, Samantha Lomnicki, Leah M Chase, Bryan F Peterson, Natalie Reizine, Lindsay Alpert, Namrata Setia, Shu-Yuan Xiao, John Hart, Uzma D Siddiqui, Kyle Hogarth, Oliver S Eng, Kiran Turaga, Kevin Roggin, Mitchell C. Posner, Paul Chang, Sunil Narula, Murtuza Rampurwala, Yuan Ji, Theodore Karrison, Chih-Yi Liao, Blase N Polite and Hedy L Kindler
    Cancer Discov December 3 2020 DOI:10.1158/2159-8290.CD-20-1408

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Clinicogenomic analysis of FGFR2-rearranged cholangiocarcinoma identifies correlates of response and mechanisms of resistance to pemigatinib
    Ian M. Silverman, Antoine Hollebecque, Luc Friboulet, Sherry Owens, Robert C. Newton, Huiling Zhen, Luis Feliz, Camilla Zecchetto, Davide Melisi and Timothy C Burn
    Cancer Discov November 20 2020 DOI:10.1158/2159-8290.CD-20-0766

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Machine learning and chemico-genomics approach defines and predicts cross-talk of Hippo and MAPK pathways
    Trang H Pham, Thijs J Hagenbeek, Ho-June Lee, Jason Li, Christopher M Rose, Eva Lin, Mamie Yu, Scott E Martin, Robert Piskol, Jennifer A. Lacap, Deepak Sampath, Victoria C. Pham, Zora Modrusan, Jennie R Lill, Christiaan Klijn, Shiva Malek, Matthew T. Chang and Anwesha Dey
    Cancer Discov November 18 2020 DOI:10.1158/2159-8290.CD-20-0706

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis
    Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H. K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M Boland, Dieuwke L Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K Jewett, Linda T Nieman, Nir Hacohen, Anders M Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber
    Cancer Discov November 17 2020 DOI:10.1158/2159-8290.CD-19-1500

Research Articles

  • Research Articles
    A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency
    Julie Le Naour, Peng Liu, Liwei Zhao, Sandy Adjemian, Zsofia Sztupinszki, Julien Taieb, Claire Mulot, Aymeric Silvin, Charles-Antoine Dutertre, Florent Ginhoux, Allan Sauvat, Giulia Cerrato, Francesca Castoldi, Isabelle Martins, Gautier Stoll, Juliette Paillet, Khady Mangane, Cornelia Richter, Oliver Kepp, Maria Chiara Maiuri, Federico Pietrocola, Peter Vandenabeele, Fabrice André, Suzette Delaloge, Zoltan Szallasi, Pierre Laurent-Puig, Jessica Zucman-Rossi, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli and Guido Kroemer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-0465

  • Research Articles | AuthorChoice
    Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
    Joanna C. Fowler, Charlotte King, Christopher Bryant, Michael W.J. Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C. Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A. Hall, Moritz Gerstung and Philip H. Jones
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-1092

  • Research Articles | AuthorChoice | AUTHOR MANUSCRIPT
    The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG
    Haobin Ye, Mohammad Minhajuddin, Anna Krug, Shanshan Pei, Chih-Hsing Chou, Rachel Culp-Hill, Jessica Ponder, Erik De Bloois, Björn Schniedewind, Maria L. Amaya, Anagha Inguva, Brett M Stevens, Daniel A. Pollyea, Uwe Christians, H. Leighton Grimes, Angelo D'Alessandro and Craig T. Jordan
    Cancer Discov November 9 2020 DOI:10.1158/2159-8290.CD-20-0318

  • Research Articles | AuthorChoice | AUTHOR MANUSCRIPT
    Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy
    Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G Smith, Ferenc Reinhardt, Esmee Hoefsmit, Bimarzhan Assatova, Julia Casado, Marie-Charlotte Meinsohn, M Inmaculada Barrasa, George W Bell, Fernando Perez-Villatoro, Kaisa Huhtinen, Johanna Hynninen, Jaana Oikkonen, Pamoda M Galhenage, Shailja Pathania, Paula T Hammond, Benjamin G Neel, Anniina Färkkilä, David Pépin and Robert A. Weinberg
    Cancer Discov November 6 2020 DOI:10.1158/2159-8290.CD-20-0818

  • Research Articles | AuthorChoice | AUTHOR MANUSCRIPT
    Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer
    Shuang Zhang, Sonia Iyer, Hao Ran, Igor Dolgalev, Shengqing Gu, Wei Wei, Connor J.R. Foster, Cynthia A. Loomis, Narciso Olvera, Fanny Dao, Douglas A Levine, Robert A. Weinberg and Benjamin G Neel
    Cancer Discov November 6 2020 DOI:10.1158/2159-8290.CD-20-0455

  • Research Articles | AUTHOR MANUSCRIPT
    Epigenetic and transcriptional control of the epidermal growth factor receptor (EGFR) regulates the tumor immune microenvironment in pancreatic cancer
    Jinyang Li, Salina Yuan, Robert J Norgard, Fangxue Yan, Yu H Sun, Il-Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan V. Bhanu, Benjamin A Garcia, Robert H. Vonderheide, Andrés Blanco and Ben Z. Stanger
    Cancer Discov November 6 2020 DOI:10.1158/2159-8290.CD-20-0519

  • Research Articles | AUTHOR MANUSCRIPT
    Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression
    Ralph Francescone, Débora Barbosa Vendramini-Costa, Janusz Franco-Barraza, Jessica Wagner, Alexander Muir, Allison N Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong, Dustin Rollins, Ruchi Malik, Roshan J Thapa, Diana Restifo, Yan Zhou, Kathy Q. Cai, Harvey H Hensley, Yinfei Tan, Warren D. Kruger, Karthik Devarajan, Siddharth Balachandran, Andres J. Klein-Szanto, Huamin Wang, Wafik S. El-Deiry, Matthew G. Vander Heiden, Suraj Peri, Kerry S Campbell, Igor Astsaturov and Edna Cukierman
    Cancer Discov October 30 2020 DOI:10.1158/2159-8290.CD-20-0775

  • Research Articles | AUTHOR MANUSCRIPT
    Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis
    Nicolas Gengenbacher, Mahak Singhal, Carolin Mogler, Ling Hai, Laura Milde, Ashik Ahmed Abdul Pari, Eva Besemfelder, Claudine Fricke, Daniel Baumann, Stephanie Gehrs, Jochen Utikal, Moritz Felcht, Junhao Hu, Matthias Schlesner, Rienk Offringa, Sudhakar Chintharlapalli and Hellmut G. Augustin
    Cancer Discov October 26 2020 DOI:10.1158/2159-8290.CD-20-0122

  • Research Articles | AuthorChoice | AUTHOR MANUSCRIPT
    Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin
    Elisa Espinet, Zuguang Gu, Charles D. Imbusch, Nathalia A Giese, Magdalena Buscher, Mariam Safavi, Silke Weisenburger, Corinna Klein, Vanessa Vogel, Mattia Falcone, Jacob Insua-Rodriguez, Manuel Reitberger, Vera Thiel, Steffi O. Kossi, Alexander Muckenhuber, Karnjit Sarai, Alex YL Lee, Elyne Backx, Soheila Zarei, Matthias M. Gaida, Manuel Rodriguez-Paredes, Elisa Donato, Hsi-Yu Yen, Roland Eils, Matthias Schlesner, Nicole Pfarr, Thilo Hackert, Christoph Plass, Benedikt Brors, Katja Steiger, Dieter Weichenhan, H. Efsun Arda, Ilse Rooman, Janel L Kopp, Oliver Strobel, Wilko Weichert, Martin R. Sprick and Andreas Trumpp
    Cancer Discov October 15 2020 DOI:10.1158/2159-8290.CD-20-1202

  • Research Articles | AUTHOR MANUSCRIPT
    The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
    Deobrat Dixit, Briana C Prager, Ryan C Gimple, Hui Xian Poh, Yang Wang, Qiulian Wu, Zhixin Qiu, Reilly L. Kidwell, Leo J. Y. Kim, Qi Xie, Kristoffer Vitting-Seerup, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R. Jaffrey, Jing Crystal Zhao, Xiuxing Wang and Jeremy N. Rich
    Cancer Discov October 6 2020 DOI:10.1158/2159-8290.CD-20-0331

Research Brief

  • Research Brief | AUTHOR MANUSCRIPT
    A critical role for fas-mediated off-target tumor killing in T cell immunotherapy
    Ranjan Upadhyay, Jonathan A. Boiarsky, Gvantsa Pantsulaia, Judit Svensson-Arvelund, Matthew J. Lin, Aleksandra Wroblewska, Sherry Bhalla, Nathalie Scholler, Adrian Bot, John M Rossi, Norah Sadek, Samir Parekh, Alessandro Laganà, Alessia Baccarini, Miriam Merad, Brian D Brown and Joshua D Brody
    Cancer Discov January 14 2021 DOI:10.1158/2159-8290.CD-20-0756

  • Research Brief | AuthorChoice | AUTHOR MANUSCRIPT
    A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention
    Spencer C Wei, Wouter C Meijers, Margaret L Axelrod, Nana-Ama A.S. Anang, Elles M Screever, Elizabeth C Wescott, Douglas B. Johnson, Elizabeth Whitley, Lorenz Lehmann, Pierre-Yves Courand, James J Mancuso, Lauren E Himmel, Benedicte Lebrun-Vignes, Matthew J. Wleklinski, Bjorn C. Knollmann, Jayashree Srinivasan, Yu Li, Oluwatomisin T. Atolagbe, Xiayu Rao, Yang Zhao, Jing Wang, Lauren I R Ehrlich, Padmanee Sharma, Joe-Elie Salem, Justin M Balko, Javid J Moslehi and James P. Allison
    Cancer Discov December 1 2020 DOI:10.1158/2159-8290.CD-20-0856

Research Briefs

  • Research Briefs | AuthorChoice | AUTHOR MANUSCRIPT
    Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations
    Jian Carrot-Zhang, Giovanny Soca-Chafre, Nick Patterson, Aaron R. Thorner, Anwesha Nag, Jacqueline Watson, Giulio Genovese, July Rodriguez, Maya K. Gelbard, Luis Corrales-Rodriguez, Yoichiro Mitsuishi, Gavin Ha, Joshua D. Campbell, Geoffrey R. Oxnard, Oscar Arrieta, Andres F. Cardona, Alexander Gusev and Matthew Meyerson
    Cancer Discov December 2 2020 DOI:10.1158/2159-8290.CD-20-1165

  • Research Briefs | AuthorChoice | AUTHOR MANUSCRIPT
    Lower airway dysbiosis affects lung cancer progression
    Jun-Chieh J Tsay, Benjamin G Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L Bessich, Robert L Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N Rom, Daniel H Sterman, Harvey I Pass, Jose C Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos and Leopoldo N Segal
    Cancer Discov November 11 2020 DOI:10.1158/2159-8290.CD-20-0263

  • Research Briefs | AuthorChoice | AUTHOR MANUSCRIPT
    Somatic HLA class I loss is a widespread mechanism of immune evasion which refines the use of tumor mutational burden as a biomarker of checkpoint inhibitor response
    Meagan Montesion, Karthikeyan Murugesan, Dexter X Jin, Radwa Sharaf, Nora Sanchez, Ameet Guria, Max Minker, Gerald Li, Virginia Fisher, Ethan S Sokol, Dean C Pavlick, Jay A Moore, Alan Braly, Gaurav Singal, David Fabrizio, Leah A Comment, Naiyer A. Rizvi, Brian M Alexander, Garrett M. Frampton, Priti S Hegde and Lee A Albacker
    Cancer Discov October 30 2020 DOI:10.1158/2159-8290.CD-20-0672

Research Watch

  • Research Watch
    Epstein–Barr Virus–Induced Antitumor Immune Response May Be Harnessable
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-005

    B-cell expression of the EBV protein LMP1 elicited T-cell responses against tumor-associated antigens.

  • Research Watch
    FBXO44 Silences Repetitive Elements during DNA Replication in Cancer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-003

    FBXO44 bound H3K9me3 at replication forks, recruiting a complex to repress repetitive elements.

  • Research Watch
    Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitors
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-004

    Structural and biochemical analyses uncovered the substrate binding and transport mechanisms of MCT1.

  • Research Watch
    A CD40 Agonistic Antibody Shows Signs of Efficacy in Pancreatic Cancer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-006

    Sotigalimab had manageable toxicity and an early efficacy signal in a phase Ib pancreatic cancer trial.

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Cancer Discovery
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