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Cancer Discovery
Cancer Discovery
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OnlineFirst

January 15, 2021

  • Research Watch
    FBXO44 Silences Repetitive Elements during DNA Replication in Cancer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-003

    FBXO44 bound H3K9me3 at replication forks, recruiting a complex to repress repetitive elements.

  • Research Articles
    A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency
    Julie Le Naour, Peng Liu, Liwei Zhao, Sandy Adjemian, Zsofia Sztupinszki, Julien Taieb, Claire Mulot, Aymeric Silvin, Charles-Antoine Dutertre, Florent Ginhoux, Allan Sauvat, Giulia Cerrato, Francesca Castoldi, Isabelle Martins, Gautier Stoll, Juliette Paillet, Khady Mangane, Cornelia Richter, Oliver Kepp, Maria Chiara Maiuri, Federico Pietrocola, Peter Vandenabeele, Fabrice André, Suzette Delaloge, Zoltan Szallasi, Pierre Laurent-Puig, Jessica Zucman-Rossi, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli and Guido Kroemer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-0465

  • Research Watch
    Epstein–Barr Virus–Induced Antitumor Immune Response May Be Harnessable
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-005

    B-cell expression of the EBV protein LMP1 elicited T-cell responses against tumor-associated antigens.

  • Review
    Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy
    Sheera R. Rosenbaum, Nicole A. Wilski and Andrew E. Aplin
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-0805

  • Research Articles | AuthorChoice
    Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
    Joanna C. Fowler, Charlotte King, Christopher Bryant, Michael W.J. Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C. Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A. Hall, Moritz Gerstung and Philip H. Jones
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-1092

  • Research Watch
    A CD40 Agonistic Antibody Shows Signs of Efficacy in Pancreatic Cancer
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-006

    Sotigalimab had manageable toxicity and an early efficacy signal in a phase Ib pancreatic cancer trial.

  • Research Watch
    Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitors
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-RW2021-004

    Structural and biochemical analyses uncovered the substrate binding and transport mechanisms of MCT1.

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation
    Yuan-Hung Lo, Kevin S. Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D. Sobba, Kasper Karlsson, Sunny J. Jones, Teri A Longacre, Amanda T. Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S. Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R. Crabtree and Calvin J. Kuo
    Cancer Discov January 15 2021 DOI:10.1158/2159-8290.CD-20-1109

January 14, 2021

  • Research Brief | AUTHOR MANUSCRIPT
    A critical role for fas-mediated off-target tumor killing in T cell immunotherapy
    Ranjan Upadhyay, Jonathan A. Boiarsky, Gvantsa Pantsulaia, Judit Svensson-Arvelund, Matthew J. Lin, Aleksandra Wroblewska, Sherry Bhalla, Nathalie Scholler, Adrian Bot, John M Rossi, Norah Sadek, Samir Parekh, Alessandro Laganà, Alessia Baccarini, Miriam Merad, Brian D Brown and Joshua D Brody
    Cancer Discov January 14 2021 DOI:10.1158/2159-8290.CD-20-0756

January 13, 2021

  • Research Article | AUTHOR MANUSCRIPT
    CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
    Dongrui Wang, Briana C Prager, Ryan C Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu, Leo J.Y Kim, Zhixin Qiu, Peng Lin, Michael H. Lorenzini, Behnam Badie, Stephen J Forman, Qi Xie, Christine E Brown and Jeremy N. Rich
    Cancer Discov January 13 2021 DOI:10.1158/2159-8290.CD-20-1243

January 12, 2021

  • Research Article | AUTHOR MANUSCRIPT
    Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia
    Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R. Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C. Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P. Gregory, Stephin J Vervoort, Kristin K Brown and Ricky W. Johnstone
    Cancer Discov January 12 2021 DOI:10.1158/2159-8290.CD-20-0738

January 11, 2021

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Targeting p300/CBP axis in lethal prostate cancer
    Jonathan Welti, Adam Sharp, Nigel Brooks, Wei Yuan, Christopher McNair, Saswati N Chand, Abhijit Pal, Ines Figueiredo, Ruth Riisnaes, Bora Gurel, Jan Rekowski, Denisa Bogdan, William West, Barbara Young, Meera Raja, Amy Prosser, Jordan Lane, Stuart Thomson, Jenny Worthington, Stuart Onions, Jonathan Shannon, Silvia Paoletta, Richard Brown, Don Smyth, Gareth W Harbottle, Veronica S Gil, Susana Miranda, Mateus Crespo, Ana Ferreira, Rita Pereira, Nina Tunariu, Suzanne Carreira, Antje J Neeb, Jian Ning, Amanda Swain, David Taddei, Stand Up to Cancer-PCF International Dream Team, Matthew J Schiewer, Karen E Knudsen, Neil Pegg and Johann S. de Bono
    Cancer Discov January 11 2021 DOI:10.1158/2159-8290.CD-20-0751

January 08, 2021

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem
    Clay McLeod, Alexander M Gout, Xin Zhou, Andrew Thrasher, Delaram Rahbarinia, Samuel Warren Brady, Michael Macias, Kirby Birch, David Finkelstein, Jobin Sunny, Rahul Mudunuri, Brent A. Orr, Madison Treadway, Bob Davidson, Tracy K. Ard, Arthur Chiao, Andrew Swistak, Stephanie Wiggins, Scott Foy, Jian Wang, Edgar Sioson, Shuoguo Wang, J Robert Michael, Yu Liu, Xiaotu Ma, Aman Patel, Michael N Edmonson, Mark R Wilkinson, Andrew M Frantz, Ti-Cheng Chang, Liqing Tian, Shaohua Lei, S. M. Ashiqul Islam, Christopher Meyer, Naina Thangaraj, Pamella Tater, Vijay Kandali, Singer Ma, Tuan Nguyen, Omar Abdulgafoor Serang, Irina McGuire, Nedra Robison, Darrell Gentry, Xing Tang, Lance E Palmer, Gang Wu, Ed Suh, Leigh Tanner, James McMurry, Matthew Lear, Alberto S. Pappo, Zhaoming Wang, Carmen L. Wilson, Yong Cheng, Soheil Meshinchi, Ludmil B. Alexandrov, Mitchell J Weiss, Gregory T. Armstrong, Leslie L. Robison, Yutaka Yasui, Kim E. Nichols, David W. Ellison, Chaitanya Bangur, Charles G. Mullighan, Suzanne J. Baker, Michael A. Dyer, Geralyn Miller, Scott Newman, Michael Rusch, Richard Daly, Keith Perry, James R. Downing and Jinghui Zhang
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-20-1230

  • Research Watch
    Chromothripsis Generates Oncogene-Containing Extrachromosomal DNA
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-RW2021-002

    Chromothripsis (chromosome shattering) produced extrachromosomal DNA with amplified oncogenes.

  • Research Watch
    First Trial of a DARPin for Cancer Shows Promising Efficacy Signal
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-RW2021-001

    In a phase I trial, the DARPin MG0250 had an expected safety profile and early signs of efficacy.

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells
    Simon J Dovedi, Matthew J Elder, Chunning Yang, Suzanne I Sitnikova, Lorraine Irving, Anna Hansen, James Hair, Des C Jones, Sumati Hasani, Bo Wang, Seock-Ah Im, Ben Tran, Deepa S Subramaniam, Shelby D Gainer, Kapil Vashisht, Arthur Lewis, Xiaofang Jin, Stacy Kentner, Kathy Mulgrew, Yaya Wang, Michael G Overstreet, James Dodgson, Yanli Wu, Asis Palazón, Michelle Morrow, Godfrey J Rainey, Gareth J Browne, Frances Neal, Thomas V Murray, Aleksandra D Toloczko, William Dall'Acqua, Ikbel Achour, Daniel J Freeman, Robert W Wilkinson and Yariv Mazor
    Cancer Discov January 8 2021 DOI:10.1158/2159-8290.CD-20-1445

January 07, 2021

  • News in Brief
    Proteomics Sharpens Brain Tumor Genomic Analysis
    Cancer Discov January 7 2021 DOI:10.1158/2159-8290.CD-NB2020-119

    Combination approach uncovers novel treatment avenues.

January 06, 2021

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes
    Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears and Dipali Sharma
    Cancer Discov January 6 2021 DOI:10.1158/2159-8290.CD-20-0537

January 05, 2021

  • News in Brief
    More Data, More Benefit with T-DXd in Breast Cancer
    Cancer Discov January 5 2021 DOI:10.1158/2159-8290.CD-NB2020-121

    With longer follow-up, PFS increases; early OS results seem promising.

January 04, 2021

  • Science in Society | Free Article
    Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited
    Antoni Ribas, Rajarshi Sengupta, Trevan Locke, Sayyed Kaleem Zaidi, Katie M. Campbell, John M. Carethers, Elizabeth M. Jaffee, E. John Wherry, Jean-Charles Soria and Gypsyamber D'Souza; for the AACR COVID-19 and Cancer Task Force
    Cancer Discov January 4 2021 DOI:10.1158/2159-8290.CD-20-1817

December 30, 2020

  • News in Brief
    AML Prognoses Better with Menin–MLL Inhibitor?
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-NB2020-120

    KO-539 induced complete remissions in two patients with relapsed/refractory disease.

  • Research Watch
    Patients with Cancer Seroconvert Typically After SARS-CoV-2 Infection
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-RW2020-188

    Patients with cancer and controls developed IgGs at the same rate and in the same time span.

  • News in Brief
    Piecing the Puzzle of Exceptional Responders
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-NB2020-118

    NCI initiative yields mechanistic explanations for nearly one quarter of standout responses.

  • Research Watch
    Immunosuppressive Macrophages Limit PARP Inhibitor Efficacy in TNBC
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-RW2020-185

    PARP inhibitor treatment increased tumor infiltration by immunosuppressive macrophages in vivo.

  • Research Watch
    IFNγ-Mediated Tryptophan Depletion Leads to Aberrant Polypeptide Synthesis
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-RW2020-187

    IFNγ signaling in melanoma cells caused tryptophan depletion, resulting in frameshifted polypeptides.

  • Research Watch
    H1 Loss Increases Accessibility of Stemness Genes to Drive Lymphoma
    Cancer Discov December 30 2020 DOI:10.1158/2159-8290.CD-RW2020-186

    Histone 1 (H1) deficiency altered chromatin architecture to enable transcription of stemness genes.

December 29, 2020

  • News in Brief
    MPN Driver Mutations May Occur In Utero
    Cancer Discov December 29 2020 DOI:10.1158/2159-8290.CD-NB2020-117

    Mutations promoting myeloproliferative neoplasms might be established decades before diagnosis.

December 28, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Metastasis and immune evasion from extracellular cGAMP hydrolysis
    Jun Li, Mercedes A Duran, Ninjit Dhanota, Walid K. Chatila, Sarah E Bettigole, John Kwon, Roshan K Sriram, Matthew Philip Humphries, Manuel Salto-Tellez, Jacqueline A. James, Matthew G Hanna, Johannes C. Melms, Sreeram Vallabhaneni, Kevin Litchfield, Ieva Usaite, Dhruva Biswas, Rohan Bareja, Hao Wei Li, Maria Laura Martin, Princesca Dorsaint, Julie-Ann Cavallo, Peng Li, Chantal Pauli, Lee Gottesdiener, Benjamin J DiPardo, Travis J Hollmann, Taha Merghoub, Hannah Y Wen, Jorge S. Reis-Filho, Nadeem Riaz, Shin-San Michael Su, Anusha Kalbasi, Neil Vasan, Simon N Powell, Jedd D. Wolchok, Olivier Elemento, Charles Swanton, Alexander N Shoushtari, Eileen E Parkes, Benjamin Izar and Samuel F Bakhoum
    Cancer Discov December 28 2020 DOI:10.1158/2159-8290.CD-20-0387

December 23, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing
    Matthias Jürgen Schmitt, Carlos Company, Yuliia Dramaretska, Iros Barozzi, Andreas Göhrig, Sonia Kertalli, Melanie Großmann, Heike Naumann, Maria Pilar Sanchez-Bailon, Danielle Hulsman, Rainer Glass, Massimo Squatrito, Michela Serresi and Gaetano Gargiulo
    Cancer Discov December 23 2020 DOI:10.1158/2159-8290.CD-20-0219

December 22, 2020

  • News in Brief | Free Article
    As Pandemic Continues, Screening Concerns Grow
    Cancer Discov December 22 2020 DOI:10.1158/2159-8290.CD-NB2020-116

    Patients hesitant to return to health centers; missed exams mean more advanced disease.

December 21, 2020

  • News in Brief
    FDA Encourages Greater Trial Diversity
    Cancer Discov December 21 2020 DOI:10.1158/2159-8290.CD-NB2020-115

    Strategies include broadening eligibility criteria and reaching out to minority, low-income patients.

December 19, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Endogenous retroelement activation by epigenetic therapy reverses the Warburg effect and elicits mitochondrial-mediated cancer cell death
    Vicente Fresquet, Maria J. Garcia-Barchino, Marta J. Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria Jose Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Álvaro Martínez-Baztán, Bruno Paiva, Maria J Moreno-Aliaga, Maria D Odero, Xabier Agirre, Oscar Yanes, Felipe Prósper and Jose A Martinez-Climent
    Cancer Discov December 19 2020 DOI:10.1158/2159-8290.CD-20-1065

December 18, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells
    Jiil Chung, Yosef E Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J Haradhvala, Vanessa Bianchi, Melissa Edwards, Victoria J. Forster, Nuno M Nunes, Melissa A. Galati, Martin Komosa, Shriya Deshmukh, Vanja Cabric, Scott Davidson, Matthew Zatzman, Nicholas Light, Reid Hayes, Ledia Brunga, Nathaniel D Anderson, Ben Ho, Karl P. Hodel, Robert Siddaway, A. Sorana Morrissy, Daniel C Bowers, Valérie Larouche, Annika Bronsema, Michael Osborn, Kristina A. Cole, Enrico Opocher, Gary Mason, Gregory A Thomas, Ben George, David S Ziegler, Scott Lindhorst, Magimairajan Vanan, Michal Yalon-Oren, Alyssa T Reddy, Maura Massimino, Patrick Tomboc, An Van Damme, Alexander Lossos, Carol Durno, Melyssa Aronson, Daniel A Morgenstern, Eric Bouffet, Annie Huang, Michael D Taylor, Anita Villani, David Malkin, Cynthia E. Hawkins, Zachary F. Pursell, Adam Shlien, Thomas A Kunkel, Gad Getz and Uri Tabori
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-20-0790

  • Research Watch
    Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-RW2020-183

    In mice, obesity remodeled TME metabolism, reducing infiltration by CD8+ T cells and antitumor immunity.

  • Research Watch
    Method Aids Determination of Metastatic Potential of Cancer Cell Lines
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-RW2020-184

    Injection of DNA-barcoded cancer cell lines into mice revealed their metastatic characteristics.

  • Research Watch
    Gut Microbiome Manipulation May Facilitate Immunotherapy Response
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-RW2020-181

    Some anti–PD-1–refractory patients responded to anti–PD-1 after fecal microbiota transplantation.

  • Research Watch
    Response to Adoptive Cell Therapy Is Predicted by Stem-Like T Cells
    Cancer Discov December 18 2020 DOI:10.1158/2159-8290.CD-RW2020-182

    The presence of memory stem-like CD8+ tumor-infiltrating lymphocytes was associated with response.

December 16, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression
    John R P Knight, Constantinos Alexandrou, George L Skalka, Nikola Vlahov, Kathryn Pennel, Leah Officer, Ana Teodosio, Georgios Kanellos, David M Gay, Sebastian May-Wilson, Ewan M Smith, Arafath K Najumudeen, Kathryn Gilroy, Rachel A Ridgway, Dustin J Flanagan, Rachael C.L. Smith, Laura McDonald, Craig MacKay, Anne Cheasty, Kerri McArthur, Emma Stanway, Joshua D.G. Leach, Rene Jackstadt, Joseph A Waldron, Andrew D Campbell, Georgios Vlachogiannis, Nicola Valeri, Kevin M. Haigis, Nahum Sonenberg, Christopher G Proud, Neil P Jones, Martin E Swarbrick, Heather J. McKinnon, William J Faller, John Le Quesne, Joanne Edwards, Anne Elizabeth Willis, Martin Bushell and Owen J. Sansom
    Cancer Discov December 16 2020 DOI:10.1158/2159-8290.CD-20-0652

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Direct and Indirect Regulators of Epithelial-Mesenchymal Transition (EMT)-mediated Immunosuppression in Breast Carcinomas
    Anushka Dongre, Mohammad Rashidian, Elinor Ng Eaton, Ferenc Reinhardt, Prathapan Thiru, Maria Zagorulya, Sunita Nepal, Tuba Banaz, Anna Martner, Stefani Spranger and Robert A. Weinberg
    Cancer Discov December 16 2020 DOI:10.1158/2159-8290.CD-20-0603

December 15, 2020

  • Research Article | AUTHOR MANUSCRIPT
    Gut microbiome directs hepatocytes to recruit MDSC and promote cholangiocarcinoma
    Qianfei Zhang, Chi Ma, Yi Duan, Bernd Heinrich, Umberto Rosato, Laurence P. Diggs, Lichun Ma, Soumen Roy, Qiong Fu, Zachary J. Brown, Simon Wabitsch, Vishal Thovarai, Jianyang Fu, Dechun Feng, Benjamin Ruf, Linda L Cui, Varun Subramanyam, Karen M Frank, Sophie Wang, David E Kleiner, Thomas Ritz, Christian Rupp, Bin Gao, Thomas Longerich, Alexander Kroemer, Xin Wei Wang, Mathuros Ruchirawat, Firouzeh Korangy, Bernd Schnabl, Giorgio Trinchieri and Tim F Greten
    Cancer Discov December 15 2020 DOI:10.1158/2159-8290.CD-20-0304

December 14, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity
    Aayoung Hong, Marco Piva, Sixue Liu, Willy Hugo, Shirley H. Lomeli, Vincent Zoete, Christopher E Randolph, Zhentao Yang, Yan Wang, Jordan J. Lee, Skylar J. Lo, Lu Sun, Agustin Vega-Crespo, Alejandro J Garcia, David B. Shackelford, Steven M. Dubinett, Philip O. Scumpia, Stephanie D. Byrum, Alan J. Tackett, Timothy R. Donahue, Olivier Michielin, Sheri L Holmen, Antoni Ribas, Gatien Moriceau and Roger S. Lo
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-0873

  • Research Article | AUTHOR MANUSCRIPT
    SWI/SNF complex mutations promote thyroid tumor progression and insensitivity to redifferentiation therapies.
    Mahesh Saqcena, Luis Javier Leandro-Garcia, Jesper L.V. Maag, Vatche Tchekmedyian, Gnana P. Krishnamoorthy, Prasanna P. Tamarapu, Vera Tiedje, Vincent Reuter, Jeffrey A. Knauf, Elisa de Stanchina, Bin Xu, Xiao-Hui Liao, Samuel Refetoff, Ronald Ghossein, Ping Chi, Alan L. Ho, Richard P. Koche and James A. Fagin
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-0735

  • News in Depth | Free Article
    Cancer Immunotherapies Helped Shape COVID Vaccines
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-ND2020-018

    Prior work in oncology underpins the record-breaking speed of development.

  • In Focus
    A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer
    Portia L. Thomas, Chioma J. Madubata, Melinda C. Aldrich, Montessa M. Lee, Taofeek K. Owonikoko, John D. Minna, Charles M. Rudin, Julien Sage and Christine M. Lovly
    Cancer Discov December 14 2020 DOI:10.1158/2159-8290.CD-20-1592

December 11, 2020

  • Research Watch
    Frameshifts in Microsatellite-Unstable Tumors Create Shared Neoantigens
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-RW2020-177

    Microsatellite insertions and deletions generated antigenic mutant proteins shared among patients.

  • Research Watch
    A Lung Cancer Subtype Depends on the Hexosamine Biosynthesis Pathway
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-RW2020-179

    KRAS/LKB1-comutant NSCLC had high flux through and dependence on the hexosamine biosynthesis pathway.

  • Research Watch
    A Glioma Subtype Arises from Immature Cells and Depends on PDGFRA
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-RW2020-180

    H3.3G34R/V-mutant high-grade gliomas became reliant on activating PDGFRA mutations for maintenance.

  • News in Brief | Free Article
    Survival Factors ID'd for Patients with Blood Cancer + COVID-19
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-NB2020-112

    Age, status of cancer treatment, and cancer prognosis can determine how patients will fare.

  • Research Watch
    Genomic Screens Identify Genes That Regulate MHC-I Expression in DLBCL
    Cancer Discov December 11 2020 DOI:10.1158/2159-8290.CD-RW2020-178

    MHC-I and MHC-II regulators in lymphomas, some of which had subtype or tumor specificity, were identified.

December 04, 2020

  • Research Article | AuthorChoice | AUTHOR MANUSCRIPT
    Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia
    Bhavana Bhatnagar, Jessica Kohlschmidt, Krzysztof Mrózek, Qiuhong Zhao, James L. Fisher, Deedra Nicolet, Christopher J. Walker, Alice S Mims, Christopher Oakes, Brian Giacopelli, Shelley Orwick, Isaiah Boateng, James S. Blachly, Sophia E Maharry, Andrew J Carroll, Bayard L Powell, Jonathan E Kolitz, Richard M. Stone, John C. Byrd, Electra D. Paskett, Albert de la Chapelle, Ramiro Garzon and Ann-Kathrin Eisfeld
    Cancer Discov December 4 2020 DOI:10.1158/2159-8290.CD-20-1579

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When papers are published in an issue, they are removed from the OnlineFirst page and appear in the appropriate issue's table of contents. The date of first publication appears below each title, followed by the article's unique Digital Object Identifier (DOI).

While an article is OnlineFirst, it may be cited as shown in the following example:

Elizabeth A. Platz et al. A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment (April 1, 2011) Cancer Discov, 10.1158/2159-8274.CD-10-0020.

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Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

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