PT  - JOURNAL ARTICLE
AU  - Moschetta, Antonio
TI  - Nuclear Receptor LXR as a Novel Therapeutic Antitumoral Target in Glioblastoma
AID  - 10.1158/2159-8290.CD-11-0228
DP  - 2011 Oct 01
TA  - Cancer Discovery
PG  - 381--382
VI  - 1
IP  - 5
4099  - http://cancerdiscovery.aacrjournals.org/content/1/5/381.short
4100  - http://cancerdiscovery.aacrjournals.org/content/1/5/381.full
SO  - CANCER DISCOVERY2011 Oct 01; 1
AB  - Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor–inducible degrader of LDLR–LDLR axis as a therapeutic approach to reduce intracellular cholesterol, block tumor growth, and induce cell death. Cancer Discovery; 1(5): 381–2. ©2011 AACR. Commentary on Guo et al., p. 442.