RT Journal Article SR Electronic T1 Debugging the Black Box JF Cancer Discovery JO Cancer Discov FD American Association for Cancer Research SP 250 OP 251 DO 10.1158/2159-8290.CD-17-0070 VO 7 IS 3 A1 Yang, James C. YR 2017 UL http://cancerdiscovery.aacrjournals.org/content/7/3/250.abstract AB Summary: A better understanding of the mechanisms by which tumor rejection succeeds and fails is needed to improve immunotherapies. Here, Anagnostou and colleagues find that mutations predicted to be the most immunogenic are preferentially lost when cancer progresses through checkpoint blockade. Cancer Discov; 7(3); 250–1. ©2017 AACR.See related article by Anagnostou et al., p. 264.