RT Journal Article SR Electronic T1 FDA Offers Advice on Trial Design JF Cancer Discovery JO Cancer Discov FD American Association for Cancer Research SP OF1 OP OF1 DO 10.1158/2159-8290.CD-NB2019-115 VO 9 IS 11 YR 2019 UL http://cancerdiscovery.aacrjournals.org/content/9/11/OF1.abstract AB The FDA recently released a final guidance that outlines the specific situations in which placebos can be used in oncology clinical trials—and in which patients and investigators should be unblinded. Oncologists consider the guidance useful, but note that it largely aligns with how oncology trials are already conducted.