PT  - JOURNAL ARTICLE
AU  - Stopsack, Konrad H.
AU  - Mucci, Lorelei A.
AU  - Antonarakis, Emmanuel S.
AU  - Nelson, Peter S.
AU  - Kantoff, Philip W.
TI  - <em>TMPRSS2</em> and COVID-19: Serendipity or Opportunity for Intervention?
AID  - 10.1158/2159-8290.CD-20-0451
DP  - 2020 Jun 01
TA  - Cancer Discovery
PG  - 779--782
VI  - 10
IP  - 6
4099  - http://cancerdiscovery.aacrjournals.org/content/10/6/779.short
4100  - http://cancerdiscovery.aacrjournals.org/content/10/6/779.full
SO  - Cancer Discov2020 Jun 01; 10
AB  - TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.