RT Journal Article SR Electronic T1 TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? JF Cancer Discovery JO Cancer Discov FD American Association for Cancer Research SP 779 OP 782 DO 10.1158/2159-8290.CD-20-0451 VO 10 IS 6 A1 Stopsack, Konrad H. A1 Mucci, Lorelei A. A1 Antonarakis, Emmanuel S. A1 Nelson, Peter S. A1 Kantoff, Philip W. YR 2020 UL http://cancerdiscovery.aacrjournals.org/content/10/6/779.abstract AB TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.