RT Journal Article
SR Electronic
T1 <em>TMPRSS2</em> and COVID-19: Serendipity or Opportunity for Intervention?
JF Cancer Discovery
JO Cancer Discov
FD American Association for Cancer Research
SP 779
OP 782
DO 10.1158/2159-8290.CD-20-0451
VO 10
IS 6
A1 Stopsack, Konrad H.
A1 Mucci, Lorelei A.
A1 Antonarakis, Emmanuel S.
A1 Nelson, Peter S.
A1 Kantoff, Philip W.
YR 2020
UL http://cancerdiscovery.aacrjournals.org/content/10/6/779.abstract
AB TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.