RT Journal Article
SR Electronic
T1 Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer
JF Cancer Discovery
JO Cancer Discov
FD American Association for Cancer Research
SP 1261
OP 1262
DO 10.1158/2159-8290.CD-20-0993
VO 10
IS 9
A1 Carter, Hannah
YR 2020
UL http://cancerdiscovery.aacrjournals.org/content/10/9/1261.abstract
AB Summary: Yu and colleagues combined computational and experimental techniques to identify a new post-transcriptional regulator of metastatic potential in colon cancer. This study reveals that the RNA-binding protein RBMS1 is a positive regulator of mRNA stability for multiple genes, including the tumor suppressor AKAP12 and a WNT pathway interacting protein, SDCBP, and its loss is a common event associated with poor prognosis.See related article by Yu et al., p. 1410.