PT  - JOURNAL ARTICLE
AU  - Montal, Emily D.
AU  - White, Richard M.
TI  - The Aged Microenvironment of Melanoma Feeds Escape from Targeted Therapy
AID  - 10.1158/2159-8290.CD-20-0949
DP  - 2020 Sep 01
TA  - Cancer Discovery
PG  - 1255--1257
VI  - 10
IP  - 9
4099  - http://cancerdiscovery.aacrjournals.org/content/10/9/1255.short
4100  - http://cancerdiscovery.aacrjournals.org/content/10/9/1255.full
SO  - Cancer Discov2020 Sep 01; 10
AB  - Summary: Alicea and colleagues demonstrate that aged fibroblasts secrete lipids into the tumor microenvironment, allowing for nutrient exchange with melanoma cells. This supportive function of fibroblasts results in increased resistance to BRAF/MEKi therapy in the context of an aged microenvironment, providing crucial mechanistic insight into age-related drug resistance.See related article by Alicea et al., p. 1282.