RT Journal Article
SR Electronic
T1 Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations
JF Cancer Discovery
JO Cancer Discov
FD American Association for Cancer Research
SP CD-20-1165
DO 10.1158/2159-8290.CD-20-1165
A1 Carrot-Zhang, Jian
A1 Soca-Chafre, Giovanny
A1 Patterson, Nick
A1 Thorner, Aaron R.
A1 Nag, Anwesha
A1 Watson, Jacqueline
A1 Genovese, Giulio
A1 Rodriguez, July
A1 Gelbard, Maya K.
A1 Corrales-Rodriguez, Luis
A1 Mitsuishi, Yoichiro
A1 Ha, Gavin
A1 Campbell, Joshua D.
A1 Oxnard, Geoffrey R.
A1 Arrieta, Oscar
A1 Cardona, Andres F.
A1 Gusev, Alexander
A1 Meyerson, Matthew
YR 2020
UL http://cancerdiscovery.aacrjournals.org/content/early/2020/11/24/2159-8290.CD-20-1165.abstract
AB Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR mutation frequency compared to global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities.