RT Journal Article
SR Electronic
T1 A Presynaptic Protein Is a Net Gain for Pancreatic Tumor Progression
JF Cancer Discovery
JO Cancer Discov
FD American Association for Cancer Research
SP 230
OP 232
DO 10.1158/2159-8290.CD-20-1645
VO 11
IS 2
A1 Sherman, Mara H.
YR 2021
UL http://cancerdiscovery.aacrjournals.org/content/11/2/230.abstract
AB Summary: Cancer-associated fibroblasts conduct an aberrant wound-healing response, including mechanisms that restrain and others that support tumor progression. In this issue of Cancer Discovery, Francescone and colleagues demonstrate expression of presynaptic protein NetG1 on fibroblasts in pancreatic ductal adenocarcinoma and characterize tumor-supportive functions of NetG1 in this context, including metabolic and immune-modulatory mechanisms.See related article by Francescone et al., p. 446.