Table 1.

Examples of predictive biomarkers

TargetDrugsBiomarkerPPV/RR (%)
ERαTamoxifen, AIsER expression on IHCn20–30
HER2Trastuzumab, lapatinibHER2 expression on IHC, HER2 amplification, and FISH24 (FISH)
KITImatinibKIT mutation (exon 11 vs exon 9)70/50
EGFRCetuximab, panitumumabKRAS mutation12
BRAFPLX4032BRAF V600E mutation75
ALKCrizotinibEML4-ALK translocation57
PARPOlaparib, iniparib, veliparibBRCA1/2 mutation33–41
  • Abbreviations: AI, aromatase inhibitor; IHC, immunohistochemistry; PPV, positive predictive value; RR, response rate.