ECM componentFunctional role in chemoresistance
Collagen I, III, IVEnhances tumor cell proliferation, structural support of ECM
DecorinBinds TGF-β, tightens collagen fibrils
HASynergizes with collagen network, increases interstitial fluid pressure
VersicanEnhances tumor cell proliferation, confers resistance to apoptosis
FibronectinConfers resistance to apoptosis
LamininConfers resistance to apoptosis
Osteonectin/SPARCEnhances tumor cell proliferation and metastasis