Table 2.

Summary of inflammation subpathways, genes, and SNPs on Illumina chip

PathwayaGenes (n)SNPs (n)
Apoptosis signaling67834
Complement cascade38
Cytokine signaling2663,139
Glucocorticoid/PPAR signaling24258
Innate pathogen detection53542
Leukocyte signaling1322,023
MAPK signaling1562,854
Natural killer cell signaling31296
Phagocytosis-Ag presentation41488
PI3K/AKT signaling45580
ROS/glutathione/cytotoxic granules25231
TNF superfamily signaling49569
  • Abbreviations: Ag, antigen; AKT, MAPK, mitogen-activated protein kinase; PPAR, peroxisome proliferator-activated receptor; ROS, reactive oxygen species; SNP, single-nucleotide polymorphism.

  • a See ref. 7