Table 6.

Genetic risk score in discovery set for ACVR1B, NR4A1, and upstream and downstream SNPs

Adverse alleles (n)Cases, n (%)Controls, n (%)OR (95% CI)aP value
0–626 (5.9)64 (12.8)Ref. 
764 (14.4)112 (22.4)2.21 (1.09–4.45)0.0272
8133 (29.9)150 (29.9)3.26 (1.69–6.32)5.00 × 10−4
9+221 (49.8)175 (34.9)5.28 (2.78–10.05)3.90 × 10−7
P for trend  1.46 (1.30–1.65)1.11 ×10−9
  • a Adjusted for age, sex, environmental tobacco smoke, and lung cancer family history.