Table 1.

Distribution of selected variables in discovery and replication populations

   Discovery  Replication  
 CasesControlsOR CasesControlsOR 
Variable(n = 451)(n = 508)(95% CI)aP value(n = 303)(n = 311)(95% CI)P value
Age        
Mean (SD)61.6 (13.0)56.6 (13.1)1.03 (1.02–1.04)<0.000162.0 (12.9)62.2 (13.1)1.03 (1.02–1.04)<0.0001
Sex        
Male, n (%)147 (32.6)190 (37.4)  83 (27.4)86 (27.7)  
Female, n (%)304 (67.4)318 (62.6)0.81 (0.62–1.06)0.1198220 (72.6)225 (72.4)0.99 (0.7–1.4)0.9425
Asthma        
No369 (87.0)442 (87.3)  263 (86.8)278 (89.4)  
Yes55 (13.0)64 (12.4)1.03 (0.70–1.51)0.883040 (13.2)33 (10.6)1.28 (0.8–2.1)0.3223
Hay fever        
No332 (78.3)363 (71.7)  N/A   
Yes92 (21.7)143 (28.3)0.70 (0.52–0.95)0.022    
Dust        
No345 (81.4)429 (84.8)  N/A   
Yes79 (18.6)77 (15.2)1.28 (0.90–1.80)0.1657    
ETS        
No57 (17.0)115 (24.6)  99 (33.3)135 (43.8)  
Yes278 (83.0)353 (75.4)1.59 (1.12–2.26)0.0104198 (66.7)173 (56.2)1.56 (1.12–2.17)0.0082
Family history of lung cancer       
0348 (84.5)439 (87.1)  213 (70.3)258 (83.0)  
153 (12.9)61 (12.1)1.10 (0.74–1.63)0.648290 (29.7)53 (17.0)2.06 (1.40–3.02)0.0002
211 (2.7)4 (0.8)3.47 (1.09–10.98)0.0346