Table 3.

Significant SNPs in discovery set (additive model)

CHRSNPBPMinor alleleORL95U95P valueLocationGene
1rs10127728171417779A1.6791.2662.2260.0003Flanking_3UTRTNFSF4
1rs549471158972243A0.65110.50580.83810.0009Flanking_5UTRSLAMF7
1rs1213106567541594A1.4161.1491.7460.0011Flanking_5UTRIL12RB2
1rs230009511188304A1.3771.1311.6760.0015IntronMTOR
2rs1748889797731596G0.72010.59470.87180.0008Flanking_3UTRZAP70
2rs146457245807414A0.73920.61570.88740.0012IntronPRKCE
2rs1343227646165464C1.3581.1251.6390.0015IntronPRKCE
5rs4585495159717272A2.1471.3913.3160.0006IntronC1QTNF2
5rs745749179648409G1.3591.1311.6340.0011IntronMAPK9
5rs17651965149435808C0.60510.44540.82210.0013IntronCSF1R
6rs350294158440305G1.3991.1521.6990.0007Flanking_3UTRSYNJ2
10rs18873276648739G0.61440.46910.80470.0004Flanking_5UTRPRKCQ
11rs11819995127894601A1.4791.1861.8430.0005IntronETS1
12ars1280959750642590C0.71920.58920.87780.0012IntronACVR1B
12brs270112950715744C0.62610.47510.8250.0009Flanking_5UTRNR4A1
13rs9518587101309356G1.5041.1911.90.0006Flanking_3UTRFGF14
14rs1162126324164990A1.5811.2182.0540.0006Flanking_3UTRGZMB
14rs1162912924164696A1.7431.2532.4260.001Flanking_3UTRGZMB
14rs1115881324154521A1.7211.2362.3970.0013Flanking_5UTRGZMH
17rs116534145355762C0.50930.34090.76090.001IntronNLRP1
21rs96285933569993C0.73850.61480.88710.0012IntronIL10RB
  • Abbreviations: BP, base pair; CHR, chromosome.

  • a Replicated in the Mayo data set (OR = 0.80; 0.62–1.02); P = 0.069.

  • b Mayo data set (OR = 0.85; 0.60–1.21); P = 0.36.